Caffeine is a methylxanthine alkaloid compound,which is not only effective,but also safe and needn't monitor the plasma concentration for the prevention and treatment of apnea in preterm infants,compared with theophylline.In recent years,it has been reported that caffeine is beneficial to improve weaning extubation success rate,reduce the incidence of bronchopulmonary dysplasia in preterm infants,reduce the risk of surgical closure of patent ductus arteriosus,and improve the long-term neurological outcome in preterm infants.

Signal transduction is a very fine and complicated process that indudes participation in the cell propagation, division, maturation and apoptosis.Under normal circumstance disabled-2( Dab2) in human tissues participates in the signal transduction of the cell in order to allow the body to keep normal functions,but under some circumstances the absence of Dab2 influences the normal signal transduction path,leding to atypical cell changes.and the generation of tumors.This paper is a review on the construction and function of Dab2 and its related gene as well as the relation of Dab2 and tumors generation.

Objective:To detect the levels of T help cell 17 (Th17)/regulatory T cell (Treg) in the peripheral blood of patients with ovarian cancer and explore their clinical significances.Methods:55 patients with ovarian cancer and 60 normal controls were enrolled.The percentage of Th17/Treg cells were detected by flow cytometry (FCM).The expression of retinoid-related orphan receptor gamma-t ( RORγt)/foxhead winged-helix box protein 3 ( Foxp3) mRNA was measured by real time PCR and the plasma levels of IL-17/TGF-β1 were detected by enzyme linked immunosorbent assay (ELISA).Results: The percentage of CD4+IL-17+/CD4+T cells,the mRNA expression of RORγt and the plasma levels of IL-17 increased significantly in patients with ovarian cancer than in normal controls (P<0.05).Compared with normal controls,the percentage of CD4+Foxp3+Treg/CD4+T cells,the mRNA expression of Foxp3 and the plasma levels of TGF-β1 increased significantly in patients with ovarian cancer ( P<0.05).Conclusion:The imbalance of Th17/Treg cells may exist in the peripheral blood of patients with ovarian cancer.Th17/Treg cells may participate the pathology of ovarian cancer.

Open-path Fourier transform infrared ( OP/FT-IR) spectra were analyzed with target factor analysis ( TFA) and band-target entropy minimization ( BTEM) respectively, with the purpose to reconstruct spectral characteristics of target molecules from matrices of spectra. Five sessions of continuous OP/FT-IR monitoring were carried out around farms. For each session, the spectra were arranged row-wisely in order of measuring time, which yielded five matrices for data analysis. Results showed that both BTEM and TFA could reconstruct spectral characteristics of target molecules from the spectral data matrix, but the performance of the two methods differed slightly. TFA can retrieve spectral features of target molecules in the presence of interferences, and the reconstructed spectra are similar to corresponding reference. BTEM can implement such spectral retrieval without the reference spectrum. This work presents not only the application of BTEM method to qualitative analysis for OP/FT-IR spectra, but also a thorough comparison between the two methods. The conclusion is helpful to qualitative analysis of complex multi-component systems.

With the development of breast-conserving surgery,the problem of local relapse after conservation therapy became a hot spot for discussion.There was much research done on the influential factors of recurrence after conservation therapy,however,there is little research on the strategy for salvage of relapse.This review summarizes the recent research on the diagnosis,treatment and prognosis of local recurrence of breast cancer after conservation therapy.

Objective To sum up the observation points and nursing measures for patients with subclavian steal syndrome after stent implantation,improve the predictive nursing and reduce the occurrence of postoperative complications. Methods Reviewed and summarized the nursing process and experience of 19 cases after stent implantation. Included prevention from complication, discharge guidance,the close observation of vital signs and the changes of disease. Results All 19 patients were cured after stent implantation and no serious complication occurred. Conclusions Endovascular stenting is an effective way for the treatment of subclavian steal syndrome. meticulous nursing and prevention of complications can ensure the success of surgery in the process of treatment .

Acute Disease ; Adolescent ; Adult ; Aniline Compounds ; poisoning ; Humans ; Male ; Middle Aged ; Occupational Diseases ; chemically induced ; diagnosis ; drug therapy ; Poisoning ; diagnosis ; drug therapy

ObjectiveTo observe whether if intravenous infusion of dexmedetomidine in advance can prevent irritation and cough causing by sufentanil.MethodsNinety patients who performed excision of intracranial tumor were divided into observation group and control group by random digits table with 45 cases each.Patients in observation group were intravenously infused 0.5 μg/kg dexmedetomidine for 10 minutes before induction.Patients in control group were intravenously infused 0.9％ sodium chloride for 10 minutes before induction.All the patients were intravenously infused 0.3 μg/kg sufentanil after taking drugs of load dosage in 3 seconds,and the incidence of irritation and cough in 1 minute was observed.The mean arterial pressure and heart rate were recorded before infusing dexmedetomidine or sodium chloride(T0),at the end of infusing dexmedetomidine or sodium chloride (T1),before intubation (T2),1 minute after intubation (T3).ResultsThe incidence of irritation and cough,moderate-severe irritation and cough in observation group [ 24.4％ ( 11/45 ),11.1％ (5/45) ] were lower than those in control group [ 48.9％ (22/45),22.2％ ( 10/45 ) ]with significant differences(P＜ 0.01 ).The mean arterial pressure in control group at T2 was lower than that in observation group [ (71.2 ± 3.5) mm Hg( 1 mm Hg =0.133 kPa) vs.(84.7 ± 4.1 ) mm Hg] with significant difference (P ＜ 0.05 ).The mean arterial pressure in control group at T3 was higher than that in observation group [(96.7 ± 6.4) mm Hg vs.(83.1 ± 5.2) mm Hg] with significant difference(P＜ 0.05).The heart rate at T1,T2,T3 in observation group was lower than that in control group [ (53.2 ± 4.7 ) beats/min vs.(70.4 ± 6.2 )beats/min,(56.3 ± 3.1 ) beats/min vs. (64.7 ± 3.7) beats/min,(59.1 ± 4.8) beats/min vs. (81.5 ± 6.1 )beats/min],and there were significant differences(P ＜0.05).Conclusions Intravenous infusion of dexmedetomidine (0.5 μg/kg) in advance can effectively prevent irritation and cough causing by sufentanil,and can enhance the stability of circulation during intubation.

Objective To evaluate the cool-tip radiofrequency treatment of uterine myoma. Methods 42 volun-tary patients were treated with cool-tip radiofrequeney electrode,in ultrasound-guided,via abdominal or vaginal inser-tion the uterine myoma. The diameter of 56 uterine myomas was from 3.0 cm to 8.0 cm. Results After the treat-merit,following-up the 56 uterine myomas of 42 patients for more than 3 months,the curative rate was 100%. Con-clusion With tiny wound and remains the functions of uterus, the cool-tip radiofrequency is an effective, simple,safe and reliable technique on the therapy of uterine myoma. It can be applied to any site of the uterine myoma.

The standardized prevalences of CDS suggestiondiagnosed metabolic syndrome(MS) and its components were 11.46% in MS,5.17% in diabetes,16.35% in hypertension,25.59% in high triglyceride level,4.72% in low HDL-C level,18.84% in overweight or obesity in 2512 randomized official employees in Fushan city of Guangdong province in 2003.The MS prevalence was increased with ageing.