Fracture healing consists of four stages: hematoma and inflammation, granulation tissue formation, membranous and endochondral ossification, and remodeling. During these stages, the pathological changes are continuous and overlapping and numerous inflammatory factors and growth factors play a central role in the tissue regeneration and ossification. The fracture will eventually reach primary bone healing or callus healing depending on the stability of fracture site after treatment. The delayed union and nonunion can be assessed according to the treatment time, clinical examination, radiology and biomechanical testing. It is important to understand the differences between hypertropic and atrophic nonunions and the reasons that lead to nonunion. At last, methods to promote fracture healing are summarized and classified into four groups: biological, systemic, mechanical and biophysical ones.

Acute compartment syndrome (ACS) is still an emergent situation in traumatic orthopaedics. Its pathophysiologic mechanism and treatment principles have already been recognized and established widely. The main factors which affect the prognosis are early diagnosis and timing of surgical treatment. This review analyzes the methods of clinical and instrumental diagnosis,rectifies some misunderstandings in clinical evaluation and makes suggestions on appropriate monitoring.

Objective To observe the efficacy of treatment of cirrhosis ascites with integrated traditional Chinese medicine and western medicine. Methods All patients were randomly divided into a treatment group (27 cases) and a control group (25 cases). Patients in the treatment group were treated with integrated traditional Chinese and western medicine, while patients in the control group were treated with western conventional therapy. Resulta The total effective rate in the treatment group was 96.3%, showing significant difference (P＜0. 05) contrasting 72% in the control group. Conclusion It is effective that treating cirrhosis ascites with integrated traditional Chinese and western medicine.

This article presents a new digital haemoglobin meter.This device adopts HICN method recommended by WHO.Its unique designing of automate proofread zero circuit and automatic controlling in determination provids high accuracy and stability,handy and reliable,It can be widely used in the hospital chemical ex- amination laboratory,commue hospital,health station and related laboratory.

Objective To study the expression patterns of neuropeptide Y(NPY)and vasoactive intestine peptide(VIP)during the bone development,and its possible relationship with angioge nesis and osteoblast differ-entiation.Methods The bones of low extremity of SD embry o and new -born rats were taken,fixed in formalin and packed by paraffin wax.The developmental stages of bone were determi ned by HE stain The representative specimen were picked out and within t he same layer the sections were taken immunohistochemical stain respective to anti-NPY,VIP,vasoepithelial grow th factor(VEGF)and alkaline phosphatatase(AP).The location and intensity of stain were compared by microscopi c observation.Results During the earliest stage of osteoge nesis,there was no sign of angiogenesis while osteob last began to differentiate and it parallels the intensity of ossificati on activity.At the first ossification center,the l ocation and pattern of NPY expressio n are similar to those of VEGF.Conclusions Due to VIP expression at the earliest stage of osteogenesis,the bone tissue may have the independent nerve control before angiogenesis.The expression similarity of timing and lo cation between NPY and VEGF suggests there is certain relationship between NPY-energetic nerve and angiogenesis.

Objective:To investigate the present conditions and prospects of chitin and its derivatives use for tissue engineering. Methods:The literatures about the use in tissue engineering of chitin and its derivatives were widely reviewed, at one time, analysed the present conditions of them. ResultSrThere are two aspects about the major use of chitin and its derivatives for tissue engineering, one is act as a sustained release agent, the other is act as a biology scaffold material, and it had made an importan role in reconstruction of many kinds of tissues. Conclusion:Chitin and its derivatives were a kind of nature high polymer material which have distinctive biologic activity. It will be a wide prospect in study of tissue engineering. The focal point of chitin and its derivatives will focus on the compound materials.

OBJECTIVE To explore the method for sterilizing hands which is effective,convenient and without stimulation for medical personnel.METHODS A total of 150 nurses on duty were divided into three groups randomly.In the test groups 1and 2,towels with 0.2% peracetic acid and BANENG disinfectant fluid were used separately,but in the control group only soap with flowing water was used for hands sterilization.RESULTS The rate of bacterial removal was 98.82%,72.63% and 68.64%,respectively,among the 3 groups.The efficacy of BANENG disinfectant fluid was similar to 0.2% peracetic acid.Both of them showed significant differences compared with control group.CONCLUSIONS Both 0.2% Peracetic acid and BANENG disinfectant fluid have better disinfection efficacy,and BANENG disinfectant fluid is more easier in use.

Objective To assess the feasibility and clinical effect of hand-assisted laparoscopic cholecystojejunostomy and gastroenterostomy combined with()~(125)I seed implantation for the treatment of advanced pancreatic carcinoma.Methods Hand-assisted laparoscopic cholecystojejunostomy and gastroenterostomy combined with()~(125)I seed implantation was performed in 12 patients with advanced pancreatic carcinoma(pancreatic head,10 patients;pancreatic body,2 patients) between February 2002 and August 2004 in this hospital.Results All the operations were successfully accomplished.The operative time was 104~181 min(122?29 min),the operative blood loss was 45~152 ml(60?18 ml),and the length of hospital stay, 6~17 d(8.5?1.3 d).Postoperatively,the jaundice subsided gradually,and the patient's liver functions recovered to normal in 7~10 days.The abdominal pain disappeared in 3 patients and was obviously remitted in 7.Gastrointestinal dysfunction occurred in 2 patients and was cured with symptomatic therapy.Follow-up checkups with CT scannings in 10 patients for 6 months showed partial remission(PR) in 4 patients,no changes(NC) in 4 patients,and progressed disease(PD) in 2.Conclusions Hand-assisted laparoscopic internal drainage combined with()~(125)I seed implantation for the treatment of advanced pancreatic carcinoma is effective and micro-invasive.

Objective To observe the clinical efficacy of mifepristone complex combination of uterine fibroids suffer psychological intervention.Methods70 patients of uterine fibroids from January 2014 to January 2015, were randomly divided into observation group and control group of 35 cases.The control group psychological intervention group conventional therapy based on the use of mifepristone treatment, the control group were treated with conventional therapy alone psychological intervention, recording and analysis of therapeutic effect of two groups of patients.ResultsThe patients with hemoglobin levels and fibroid volume were (99.57±10.46)g/L, (69.65±10.25)cm3 after treatment than the control group (89.94±9.15)g/L, (142.06±12.49)cm3, and the difference was significant (P<0.05);after treatment observation group total effective rate was 80.0%, higher than 57.14%, and the difference was significant (P<0.05).ConclusionMifepristone combined with psychological intervention uterus Efficacy fibroids sure, exactly, compared with the individual application of psychological intervention no significant adverse reactions, can effectively improve the symptoms of patients with uterine fibroids.

This paper is to study the inhibitory effect of water soluble polymers--methyl cellulose (MC), hydroxypropyl methyl cellulose (HPMC), hydroxypropyl cellulose (HPC-M), poloxamer (F68) and polyvidon (PVP) on osthole (OST) crystallization and investigate the impact of polymer concentration and viscosity on crystallization behavior. Also, UV spectrophotometry method was used to determine the drug concentration at different time point to draw the OST concentration-time curve. Results show that HPMC has the most significant inhibition effect on OST crystallization, and drug concentration level is 1.61 times higher than that in control solution within 8 h followed by PVP (1.54) and MC (1.45) respectively. The kinetics of OST recrystallization can be described using first-order reaction, and the crystallization rate constants obtained by analyzing the regression equation indicate that HPMC-60SH-4000 and HPMC-60SH-10000 can greatly influence OST crystal formation. The dissolution rate of drugs precipitated from water-soluble polymer solutions is faster compared with controls in pH 1.2 HCl and pH 6.8 phosphate buffers, which demonstrated that water-soluble polymers can not only change the behavior of drug crystallization but markedly improve the dissolution rate of water insoluble drugs.