Objective To study the expression and clinical significance of thyroid transcription factor-1 (TTF-1) in stage Ⅰ non-small cell lung cancer (NSCLC) after operation and to 1 investigate the values in identification of the prognosis of stage Ⅰ NSCLC.Methods The expression of TTF-1 in 129 specimens of stage Ⅰ NSCLC was detected by immunohistochemistry.Results The positive rate of TTF-1 in stage Ⅰ NSCLC was 64.3％.There were significant differences in TTF-1 expression rate among pathological subtypes (x2 =25.231,P ＜ 0.001),different ages (x2 =4.581,P =0.032),sex (x2 =4.900,P =0.027) and differentiation degrees(x2 =11.519,P =0.019).Univariate analysis suggested that in the stage Ⅰ NSCLC patients,the median disease-free survival and overall survival of those positive for TTF-1 expression were superior to those negative:38.9 months versus 27.8 months (P =0.023) and 64.10 months versus 50.68months (P =0.013).Cox regression analysis suggested that TTF-1 expression,tumor differentiation degrees were independent factors affecting the prognosis of stage Ⅰ NSCLC.Conclusion Patients with TTF-1 positive expression often had better survival.Positive expression of TTF-1 and differentiation degree of tumor were independent prognostic factors to affect the prognosis of NSCLC.

Objective To investigate and analyze the level of the transition shock of newly graduated nurses, and to provide the basis for improving measures to accelerate the transition period of new nurses. Methods A total of 824 new nurses coming from Shandong Province and Heilongjiang Province were recruited and investigated with the Transition Shock of Newly Graduated Nurses Scale ( TSNGNS) . To observe scores of transition shock in new nurses,scores of different conditions in new nurses and influencing factors on transition shock in new nurses. Results The scores of transition shock of new nurses ranged from 85 to 135. The score of physical were the highest of all (28. 96 ± 1. 851), with a percentage of 96. 53%. There were significant differences in different ages, working time, education levels, hospital areas and pre-service training time ( F/t=14. 715, 53. 742, 28. 792, 6. 911, 31. 829, respectively;P <0. 05). The impact factors of transition shock were working time, hospital area, pre-service time and education level. The degree could explain the dependent variable was 23. 2%. Conclusions The transition shock of new nurse is at a high level, and restrains by working time, education level, the hospital area and pre-service training time.