Objective To investigate the clinical effect of edoravone combined with escin monosodium on the treatment of acute cerebral hemorrhage .Methods 60 patients suffered from acute cerebral hemorrhage were randomly divided into control group and observation group .Each group had 30 patients.The control group was conventionally treated by the internal medicine .On the basis of the research on the control group ,the observation group were treated by edoravone combined with escin monosodium intravenous drip .After the treatment of 14 days,28 days,the recovery of neural function,focus volume,clinical effect were evaluated.Results Comared with the control group,after the treatment of 14 days,28 days,NIHSS score was obviously lower than that of the control group ,the difference was sig-nificant (t=2.136,t=4.117,P<0.05,P<0.01).After the treatment of 14 days,hematoma and edema of the differences were not statistically significant (t=1.395,t=0.737,all P>0.05).After the treatment of 28 days,hema-toma and edema of the differences were statistically significant (t=3.140,t=2.367,P<0.01,P<0.05).The com-parison of the clinic effect of the two groups ,the total effect was statistically significant (χ2 =6.650,P <0.01). Conclusion Edaravone combined with escin monosodium on the treatment of cerebral hemorrhage can significantly improve neurologic impairment and cerebral hematoma .Clinical effect is definite and safe .

Objective To investigate the factors that influence the occurrence of hemorrhagic transformation (HT) in patients with acute massive cerebral infarction,and to provide references for clinical treatment.Methods The clinical data of 60 patients with acute ischemic stroke were retrospectively analyzed.All the 60 patients were divided into HT group and non-hemorrhagic transformation (NHT) group.Risk factors associated with cerebrovascular disease,such as general data (gender,age,histories of drink and smoke),history of past illness (hypertension,diabetes,coronary disease,atrial fibrillation and cerebral stroke) and clinical data (infarction location,therapeutic methods,blood pressure,blood glucose,blood fat,cholesterol,fibrinogen and et al),were compared between the two groups.Results Of all the 60 patients,HT rate was 35％ (21/60).Incidence of HT was higher in patients with past and present hypertension and hyperglycemia(P =0.009,0.013,0.005,0.008,0.017),and in patients with atrial fibrillation,anti-platelet therapy,infarction in cortex,and hypocholesterolemia (P =0.020,0.037,0.003,0.009).But gender,age,histories of drink and smoke and history of coronary disease were not significantly different between the two groups(P=0.935,0.309,0.196,0.717,0.058).Conclusion Hypertension,hyperglycemia,atrial fibrillation,hypocholesterolemia,anti-platelet therapy could be independent risk factors for HT in patients with acute massive cerebral infarction.