The POMS (Profile of Mood States) was used to investigate changes in mood and affect that appeared after the Portrait therapy, a method conceived and initiated by Kenichi Muraoka in 2006. The subjects consisted of 46 new nurses (1 male, 45 females, average age 23.09 years); 1 patient hospitalized in the palliative care ward (1 male in his 80s) and 1 family member attending therapy sessions (1 female in her 60s); 3 ward nurses (1 male, 2 females, average age 38.67 years); 3 students participating in hands-on training (3 females, average age 21.67 years);and an additional 3 staff members (3 males, average age 40.67 years). The POMS was administered before and after the Portrait therapy, and the changes in POMS score were examined. The new nurses showed a significant improvement in mood across all 6 subscales of the POMS. There was a general improvement in mood among the participants from the palliative care ward, exeluding the nurses. The Portrait therapy proved to be an effective means of improving the mood of participants, and bystanders as well, depending on their position. While due care is needed before implementing the Portrait therapy in a hospital ward, this therapy is a viable emotional care alternative, and is also potentially meaningful in the context of grief care. In the future, we intend to follow up with case studies and quantitative studies to find more effective Portrait therapy applications.