Objective To understand the pollution of inshore seawater and shellfish due to hepatitis A virus (HAV) in Liaoning province. Methods HAVRNA in the silted seawater sample and shellfish of sea area of Liaoning province were detected by polymerase chain reaction (PCR). Results HAVRNA was found in silted seawater samples of Yueyawan,and 5 of 25 shellfish samples. Conclusion The inshore seawater and shellfish in Liaoning province had been polluted by HAV,the sanitary inspection of which should be more strengthened