1.Creating a List of Oral Anticancer Drugs using the Simple Suspension Method for Appropriate Therapy
Manabu Amano ; Hiroyuki Hichiya ; Chimi An ; Yoshifumi Kiyohara ; Yoshito Zamami ; Mamoru Seto ; Tetsuo Inoue ; Kazuho Tanaka ; Naomi Kurata ; Fusao Komada
Japanese Journal of Social Pharmacy 2013;32(2):43-47
In cancer chemotherapy, it is very important to take into account the patient’s background. In recent years, a simple suspension method has attracted increased attention as a method that prevents changes in the stability and safety of various drugs. However, of 135 oral anticancer drugs, only 28 have been examined using this method, as of April 2013. In this study, we carefully investigated whether 53 oral anticancer drugs could be adapted to the simple suspension method, except for the 28 drugs that had already been previously reported. The results showed that most of these oral anticancer drugs could be adapted to the simple suspension method. Of seven drugs that were not adapted, six were generic drugs. In addition, it was clear that the evaluation of bicalutamide tablets was significantly different from our expected results. In conclusion, we were able to qualitatively assess all 53 oral anticancer drugs. This is equivalent to half of 107 untested drugs. These results provide useful information to cancer patients using oral anticancer drugs prepared using the simple suspension method.
2.Examination Regarding the Simple Suspension Method using Oral Anticancer Drugs
Masahiro Murakami ; Yoshihiko Ikemoto ; Narumi Toya ; Mihi Paku ; Miyuki Okuyama ; Kazuko Hatakeyama ; Satoko Katsuragi ; Masako Ohno ; Hiroyuki Hichiya ; Yoshito Zamami ; Chikaaki Muro ; Takeshi Kimura ; Naomi Kurata ; Manabu Amano
Japanese Journal of Social Pharmacy 2016;35(1):34-37
To administer oral anticancer drugs safely, the simple suspension method has been introduced in many hospitals. Therefore, concerning drugs for which it is unclear whether or not this method is applicable, testing must be able to be conducted at any time. In this study, we investigated 20 oral anticancer drugs to expand information on the application of the simple suspension method. Disintegration/suspension and permeability tests were conducted, as described in the 3rd version of the Tube Administration Handbook for Oral Drugs. All products were disintegrated/suspended after 10 minutes. On permeability tests, there was no residue in any tube for tubal feeding. On the final evaluation, the products were regarded as suitable (grade 1). Bicalutamide tablets (80 mg, TCK and KN), which were analyzed in this study, were regarded as suitable (grade 1) on the final evaluation. On the other hand, the simple suspension method is not applicable for a brand-name drug, Casodex® tablets (80 mg). This may be related to the different additives. Furthermore, the results suggest that, even when the simple suspension method is not applicable for a brand-name drug, it may become applicable for generic drugs. This may provide a new merit for promoting the use of generic drugs.