Palmoplantar pustulosis is a chronic inflammatory skin disease involving the palms and soles where
mild accumulation of helper T cells and neutrophils in the dermis histologically are observed.
Leukoencephalopathy is a brain disease affecting white matter but is rarely accompanied by skin lesion.
Here we report a unique case of leukoencephalopathy accompanied by palmoplantar pustulosis with
identical pathological feature of helper T cell accumulation in both the brain and skin, suggesting a
possible link in the pathogenesis.