1.Surgical treatment of occipital epilepsy: Basic and clinical approach
Tatsuya Tanaka ; Masato Saito ; Masao Sato ; Ryogo Anei ; Yoshimitsu Hayashi ; Satoru Hiroshima ; Ryosuke Orimoto ; Akira Hododuka ; Kiyotaka Hashizume ; Kyousuke Kamada
Neurology Asia 2011;16(Supplement 1):75-76
A kainic acid microinjection into unilateral occipital cortex induced an experimental model of occipital
lobe epilepsy in cats and rats. Elicited focal seizures in the occipital cortex promptly propagated to
the bilateral cortices and also to the subcortical structures. Behavioral and EEG observations were
well correlated to the human occipital lobe epilepsy. Metabolic study using 14C-deoxyglucose
autoradiography in rats demonstrated a rapid propagation of the hypermetabolic area in the parietal,
frontal, temporal and contralateral occipital cortices and also to the thalamus, basal ganglia, MRF and
lateral geniculate body. The result shows that not only Meyer’s loop but also subcortical fasciculus
between occipital lobe and other lobules may have an important role in the mechanism of seizure
evolution and propagation of the occipital lobe epilepsy
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