1.Screening of chronic or smoldering type adult T-cell leukemia(ATL) in health examination using E-4000 15-parameter, fully-automated hematology analyzer.
Jun SATOH ; Emiko SIGEHUJI ; Tugio KUDOH ; Eiichi OTSUKA ; Yoshiko MIZUTANI ; Hisanori KAWASAKI ; Junichi SUETSUNA ; Yoritsugu HARADA ; Mineo TSUBOI ; Mitsunobu AKASHI
Journal of the Japanese Association of Rural Medicine 1988;37(4):867-872
In Oita prefecture, where ATL is relatively endemic, the authors carried out hematology analysis using an E-4000 hematology analyzer in a health examination. This analysis screened a group of 104 males and 181 females out of randomly collected 11, 568 persons in terms of a higher (exceeded 50%) W-SCR rate (i. e. lymphocyte rate in cell size distribution). The collected peripheral blood smears from this group were further subjected to the examination of lymphocyte morphology.
Abnormal lymphocytes exhibiting dyscaryosis, such as indentation or lobulation, were observed in 11 cases, and further examination of anti-ATLA antibody and earlobe blood smears revealed eight suspected cases of ATL-related condition.
Clinical symptoms characteristic of ATL were not observed in the above eight cases, though the anti-ATLA antibody titer measured by the ELISA method increased by more than 25. In one case, being diagnosed as chronic-type ATL, abnormal lymphocytes amounted to 70% and the leukocyte count was 28, 000/μl. In the other seven cases, abnormal lymphocytes amounted to only 1-11%, and the leukocyte counts ranged from 5, 300 to 11, 100/μl, which was almost within the normal limits.
The method in reported as an useful means for screening cases of nonsymptomatic chronic or smoldering type ATL through a health examination.
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