1.Diagnostic accuracy of neuropsychological tests for classification of dementia
Takuya Yagi ; Daisuke Ito ; Daisuke Sugiyama ; Satoko Iwasawa ; Hajime Tabuchi ; Mika Konishi ; Machiko Araki ; Naho Saitoh ; Yoshihiro Nihei ; Masaru Mimura ; Norihiro Suzuki
Neurology Asia 2016;21(1):47-54
Although numerous studies have shown that each neuropsychological test is effective for diagnosing
mild cognitive impairment (MCI) or Alzheimer’s disease (AD), studies comparing diagnostic accuracies
of various neuropsychological tests are relatively rare and practical cutoff values are not available. The
present study aimed to investigate the validity of neuropsychological tests and develop cutoff values
for each in differentiating healthy control (HC), MCI and AD groups. A total of 84 HC, 187 with
MCI and 195 with AD were evaluated by the selected seven neuropsychological tests using receiver
operating characteristic (ROC) curve analysis. Logical Memory (LM) delayed recall (cutoff, 7) and
Rey Auditory Verbal Learning Test (RAVLT) delayed recall (cutoff, 6) were effective for differentiating
HC from MCI. To distinguish MCI and AD, Rey Osterrieth Complex Figure Test (ROCFT) 3 mindelayed
recall (cutoff, 6) and LM immediate recall (cutoff, 4) were excellent. Delayed recall of verbal
materials, as indexed by LM and RAVLT was sensitive for discriminating MCI from HC. Handling
visual memory traces, as indexed by ROCFT and immediate verbal information by LM were sensitive
for differentiating MCI and AD.
Alzheimer Disease
;
Dementia
;
Neuropsychological Tests
Result Analysis
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