1.Creating a List of Oral Anticancer Drugs using the Simple Suspension Method for Appropriate Therapy
Manabu Amano ; Hiroyuki Hichiya ; Chimi An ; Yoshifumi Kiyohara ; Yoshito Zamami ; Mamoru Seto ; Tetsuo Inoue ; Kazuho Tanaka ; Naomi Kurata ; Fusao Komada
Japanese Journal of Social Pharmacy 2013;32(2):43-47
In cancer chemotherapy, it is very important to take into account the patient’s background. In recent years, a simple suspension method has attracted increased attention as a method that prevents changes in the stability and safety of various drugs. However, of 135 oral anticancer drugs, only 28 have been examined using this method, as of April 2013. In this study, we carefully investigated whether 53 oral anticancer drugs could be adapted to the simple suspension method, except for the 28 drugs that had already been previously reported. The results showed that most of these oral anticancer drugs could be adapted to the simple suspension method. Of seven drugs that were not adapted, six were generic drugs. In addition, it was clear that the evaluation of bicalutamide tablets was significantly different from our expected results. In conclusion, we were able to qualitatively assess all 53 oral anticancer drugs. This is equivalent to half of 107 untested drugs. These results provide useful information to cancer patients using oral anticancer drugs prepared using the simple suspension method.
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