Abstract Objective:To evaluate the value of measurement of serum intercellular adhesion molecule-l(sICAM-l) and sE-selectin in di-agnosis and postoperative monitoring for hepatocellular carcinoma. Methods: sICAM-1 and sE-selectin were measured in patients with chronic hepatitis,liver cirrhosis,HCC and healthy controls by ELISA. Results:The mean levels of sICAM-1 and sE-selectin in 79 patients with HCC was significantly higher than that of other three groups ( P