Objective To investigate the changes of anti-cyclic citrullinated peptide antibody ,rheumatoid factor (RF) ,erythrocyte sedimentation rate(ESR) and C reactive protein(CRP) levels in the patients with early rheumatoid arthritis (RA) and their applica-tion value in the diagnosis and treatment.Methods A total of 210 cases of early RA in sixth affiliated hospital of Guangzhou Medi-cal University from December 2015 to June 2016 were selected as the RA group ,including 28 males and 182 females ,at the same time 115 cases of other rheumatism were selected as the non-RA group ,male ,including 38 males and 77 females.85 persons under-going the healthy physical examination were taken as the health group ,including 46 males and 39 females.The latex enhanced im-mune turbidimetry was adopted to quantitatively detect anti-cyclic citrullinated peptide antibody.The RF and CRP levels were quan-titatively detected by using the immune turbidimetry.The Westergren method was used to test the ESR ,their content changes in RA ,non-RA arthritis and other autoimmune diseases were detected.Results The sensitivity ,specificity ,positive predictive value , negative predictive value and Youden index of anti-cyclic citrullinated peptide antibody in the RA group were 60.95% ,97.64% , 98.46% ,50.30% and 0.59 respectively ,which of RF test were 52.38% ,95.29% ,96.49% ,44.75% and 0.48 respectively ,which of CRP test were 30.48% ,89.41% ,87.67% ,87.67% ,34.23% and 0.20 respectively ,which of ESR test were 49.52% ,87.06% , 90.43% ,41.11% and 0.37 respectively.Anti-cyclic citrullinated peptide antibody detection in the RA group was obviously higher than that of the RF test ,their test results were obviously higher than those of the non-RA group and healthy group ,the differences were statistically significant (P<0.05).CRP and ESR detection had no statistical difference between the RA group and non-RA group (P>0.05).Conclusion Anti-cyclic citrullinated peptide antibody level is higher in the patients with RA ,which is signifi-cantly superior to the RF test ,and anti-cyclic citrullinated peptide antibody detection has higher value for early diagnosis of RA.

Objective:To compare the intervention effects of neck resistance training in different postures on chronic non-specific neck pain(CNSNP)and explore a more efficient exercise therapy for CNSNP. Method:Fifty-one CNSNP patients(age 41.0±5.0 years)were randomly divided into three groups:prone neck resistance training group(group A,n=17),sitting neck resistance training group(group B,n=17)and prone control group(group C,n=17).The test measures included visual analog score(VAS),Neck Disability Index(NDI),craniocervical Angle(CVA),cervical range of motion(ROM),and Root Mean Square(RMS)of neck muscles.All measures were measured before intervention and 4 weeks after intervention. Result:The intervention effect of group A was better than that of group B and group C.Neck pain score(VAS),Neck Disability Index(NDI),craniocervical Angle(CVA),cervical flexion range of motion(ROM),cervical extension range of motion(ROM),RMS(superior tract of the trapezius muscle,flexion;Sternocleido-mastoid muscle,resting;Stemocleidomastoid muscle,extension)were significantly different from those in groups B and C(P＜0.05).There was no significant difference in RMS(upper tract of the trapezius muscle,resting)between Group A and Group B(P＞0.05),but there was a significant difference from Group C(P＜0.05). Conclusion:Neck resistance training in the prone position can more effectively reduce the VAS and RMS of neck muscles and increase the ROM and CVA of neck muscles.