The ideas for constructing information purchase platform for scientific research materials were put forward and the targets for its step-by step implementation were worked out according to the analysis of problems existed in purchasing scientific research materials with chemical agents as an example.The construction of information pur-chase platform for scientific research materials plays an important role in enhancing the cost-effectiveness of outlay for scientific research, assuring the safety of founds for scientific research, and improving the service of purchase administrative offices.

Objective To compare the effects of aspirin and clopidogrel on platelet aggregation function by TEG,and to study the antiplatelet agents tailored therapy of Thrombelastography(TEG)in treatment of cerebral infarc-tion patients.Methods 100 patients with acute cerebral infarction were included in two groups:aspirin group and clopidogrel group.The inhibitory rates of AA and ADP receptor pathway in platelets were detected by TEG.The effect of inhibitory rates in group aspirin and clopidogrel was compared with nerve function and the recurrence rate of stroke. Results The inhibitory rates of group aspirin (85.23 ±21.98)% was higher than group clopidogrel (47.31 ± 22.37)% (t =7.340,P =0.005).The patients with which the inhibitory rates showed goodby TEG in group aspirin and clopidogrel got better neurological recovery,and the patients showed goodby TEG in group aspirin got lower stroke recurrence rate within 1 year(χ2 =4.460,P =0.035;χ2 =7.232,P =0.007).Conclusion TEG had guided the antiplatelet individual therapy for cerebral infarction patients,and can be used to predict and confirm the efficacy of antiplatelet drug.

The accuracy of preoperative staging diagnosis of colorectal cancer directly determines the accuracy of treatment and prognosis.Endoscopic ultrasonography,CT,MRI and positron emission tomography/computed tomography (PET/CT) imaging have their own advantages and disadvantages in preoperative staging of colorectal cancer.According to the actual situation of patients,choosing the best method of examination,when necessary,several effective methods combined,can improve the accuracy of preoperative staging diagnosis of colorectal cancer.

Objective:To evaluate the efficacy of ultrasound combined with a nerve stimulator-guided suprapatellar anterior approach to sciatic nerve block in elderly patients undergoing knee arthroscopic surgery.Methods:Seventy American Society of Anesthesiology physical status Ⅱ or Ⅲ patients, aged>65 yr, scheduled for elective knee arthroscopic surgery, were divided into 2 groups ( n=35 each) using a random number table method: suprapatellar anterior approach group (S group) and traditional anterior approach group (T group). Puncture was performed under the guidance of ultrasound and a nerve stimulator in both groups.When dorsiflexion or plantar flexion was induced by stimulation of 0.3 mA current intensity, 0.25% ropivacaine plus 1% lidocaine (0.4 ml/kg) was injected.The success of puncture and block, depth of puncture, time to complete block, duration of block, insufficient analgesia, responses to tourniquet-induced discomfort, and block-related complications were recorded.The patients were followed up for 48 h after operation for the recovery time of foot dorsiflexion on the affected side. Results:Compared with T group, the success rate of puncture and block were significantly increased, the time to complete nerve block was shortened, the incidence of intraoperative insufficient analgesia was reduced ( P<0.05 or 0.01), and no significant change was found in the depth of puncture, duration of block, and recovery time of foot dorsiflexion on the affected side in S group ( P>0.05). No nerve block-related complications were found in the two groups. Conclusion:Ultrasound combined with a nerve stimulator-guided suprapatellar anterior approach to sciatic nerve block can provide satisfactory analgesia for elderly patients undergoing knee arthroscopic surgery with a higher safety.