Objective To investigate creatine kinase (CK) and creatine kinase isoenzyme (CK-MB) changes of patients with traumatic rupture in the early stage.Methods Eighty-six patients with traumatic rupture who were treated in the Fourth Hospital Affiliated to China Medical University were enrolled to rupture group(rupture.group) and 40 cases of patients with abdominal trauma but non-rupture were admitted to abdominal trauma group.Another 40 healthy volunteers were enrolled to healthy control group.The myocardial enzymes were detected at before operation (T0),2 h after operation(T1),12 h after operation(T2),24 h after operation (T3),3 d after operation(T4) and 7 d after operation(T5).Results The contents of CK and CK-MB in rupture group,abdominal trauma group and control group were (573.4 ± 168.6) U/L and (30.4 ± 15.3) U/L,(59.3 ± 37.5) U/L and (7.6 ± 4.8) U/L,(30.7 ± 16.2) U/L and (5.6 ± 1.4) U/L respectively.There was significant difference among three group (F =295.696,90.109 ; P ＜ 0.001).SNK test showed that the contents of CK and CK-MB in rupture group were higher than that in abdominal trauma group or control group(P ＜ 0.05),and there was no significant difference between abdominal trauma group and control group(P ＞0.05).The contents of CK and CK-MB levels in rupture group at T1,T2,T3,T4 and T5 were (668.2 ±215.4),(589.3 ± 187.6),(551.2 ±202.8),(214.9 ± 194.5),(134.2 ± 118.3) U/L and (36.8 ± 17.5),(29.3 ± 16.4),(27.9 ± 17.3),(15.6 ± 9.7),(10.1 ± 4.4) U/L respectively,which were all higher than that in abdominal trauma group (CK:(67.5 ±41.8),(43.5 ±24.7),(34.2 ± 17.6),(33.4 ±16.5),(32.2 ±17.1) U/L;CK-MB:(8.1 ±5.2),(7.5 ±4.3),(7.1 ±3.9),(6.7 ±2.5),(6.1 ± 1.9)U/L),and the differences were statistically significant(P ＜ 0.05).At T0,T1 and T3 time point,the content of CK-MB of patients with Ⅲ and Ⅳ stage in rupture group were (37.9 ± 15.2),(42.8 ± 16.9),(33.2 ± 17.2),(29.7 ± 16.6) U/L respectively,higher than that in patients with Ⅰ and Ⅱ stage ((26.5 ± 17.3),(31.2 ±18.2),(25.3±15.7),(23.2±18.4) U/L;P ＜0.05).Conclusion The CK and CK-MB levels of patients with traumatic rupture appear elevated at early stage.Meanwhile,the changes of CK-MB are positively correlated with the rupture injury classification,which indicated that myocardial injury may appear in early stage of patients with traumatic rupture.It should be concerned myocardial enzymes changes in patients as early as possible.

Objective: To examine the correlation between paliperidone plasma concentration and clinical efficacy in the patients with schizophrenia. Methods:Totally 50 schizophrenia patients were treated by paliperidone. The plasma concentration of paliperidone was monitored by RP-HPLC at the weekend of the 2 nd, 4 th and 6 th week, the clinical efficacy was evaluated using the positive and negative syndrome scale ( PANSS) , and the correlation between paliperidone plasma concentration and clinical efficacy was analyzed. Results:The mean plasma concentration of paliperidone was (31. 89 ± 17. 36) ng·ml-1 at the weekend of the 6th week, and no cor-relation was found between paliperidone plasma concentration and the clinical efficacy (r=0. 146,P=0. 074). Paliperidone plasma concentration in 12 patients with adverse drug reactions (ADR) was higher than that in the patients without ADR [(45. 87 ± 19. 21)ng ·ml-1 vs (27. 06 ± 11. 13) ng·ml-1, P <0. 01]. Conclusion: Paliperidone plasma concentration shows significant individual differences. With the increase of paliperidone plasma concentration, clinical efficacy isn't necessarily improved, while the incidence of ADR may be increased. Therefore, the monitoring of paliperidone plasma concentration is recommended to optimize the therapeutic reg-imen.

Objective To study the feasibility and curative effect of laparoscopic radical resection of rectal carcinoma. Methods Sixty-two cases were enrolled in this study between Feb 2003 and Mar 2005, including 32 cases undergoing laparoscopic radical resection (19 Dixon and 13 Miles) , and 30 cases undergoing open radical resection (22 Dixons and 8 Miles). Results The mean operation time of laparoscopic group was 195 min, and open group was 156 min (P 0. 05 ). The GI and urination function of laparoscopic group recovered faster than open group ( evacuated was 2. 7 days vs. 3. 7 days, P

With the new-style thoracentesis needles with spring-loaded valve designed by ourselves, thoracentesis were carried out in 60 patients with ages ranging from 2 to 74 years. The successful rate for the operation was 100% (198/198), without any major complications such as pneumothorax, hemothorax, pleural shock or infection. The results show that this kind of puncture needle is multi-purpose and easy to operate, with high safety and reliability.
Adolescent ; Adult ; Aged ; Child ; Child, Preschool ; Equipment Design ; Female ; Humans ; Male ; Middle Aged ; Needles ; Paracentesis ; instrumentation ; methods ; Pleural Effusion ; diagnosis ; therapy ; Young Adult

Objective: To compare the curative effect of three different surgical methods: peritoneal varicocele ligation, peritoneal single-port laparoscopy and microscopy on varicocele. Methods: Retrospective analysis of the case data of 150 patients with varicocele treated in the Affiliated Hospital of Xuzhou Medical University from September 2016 to September 2018. The average age was 24.5 years, and the age range was 22-30 years. The patients were divided into three groups according to different surgical methods: open group, laparoscopy group and microscope group, with 50 cases in each group. Patients in the open group were treated with retroperitoneal spermatic cord ligation. Patients in the laparoscopic group were treated with single-hole laparoscopic laparoscopic surgery. Patients in the microscope group were treated with microscope surgery. Operation time, postoperative hospitalization time, hospitalization cost reserved arteries, surgical complications (such as testicular hydrocele, scrotal edema, epididymitis, testicular atrophy), recurrence, and semen quality improvement were compared between three groups. Measurement data were expressed as mean ± standard deviation(Mean±SD), the two comparisons used the t test, the comparison between the three groups used the analysis of variance, and the comparison between the count data groups using the Chi-square test. Results: The operation time of the patients in the microscope group [(52.52 ± 4.29) min] was longer than that of the open group [(36.60±3.69) min] and the laparoscopic group [(39.54±2.87) min]. The difference between the two groups was statistically significant (P<0.05); but the postoperative hospitalization time and hospitalization cost of patients in the microscope group [(2.16±0.95) d, (5 251 ± 300) yuan] were higher than those in the open group [(3.80±0.78) d, (64 75±415) yuan)]and the laparoscopic group [(3.28±1.01)d, (7 379±273) yuan] . The results of pairwise comparison showed that the difference between the microscope group, the open group and the laparoscopic group was statistically significant (P<0.05). Arterial preservation in the microscope group [47(94.0%)] were compared with the open group [35 (70.0%)], and laparoscopic group [30(60.0%)] had obvious advantages. Pairwise comparison results showed that the comparison between the microscope group and the open group and the laparoscopic group was statistically significant (P<0.05). After follow-up for six months, 2 cases were lost to follow-up in the microscope group, 1 cases were lost to the open group, and 5 case was lost to the unilateral laparoscopic group. 2(4.2%) patients had complications in the microscope group, and 14 (28.6%) patients had complications in the open group; 9 (20.0%) patients had complications in the laparoscopic group, and the total incidence of complications showed a pairwise comparison, the difference between the microscope group, the open group and the laparoscopic group was significant (P<0.05). The recurrence rate in the microscope group was 2.1% (1/48), the recurrence rate in the open group was 18.4% (9/49), and the recurrence rate in the laparoscopic group was 13.3% (6/45); the recurrence rate was compared in pairs, the difference between the microscope group, the open group and the laparoscopic group was significant (P<0.05) . The improvement rate of semen quality in the microscope group was 68.8% (33/48), the open group was 42.9%(21/49), the laparoscopic group was 55.6%(25/45), pairwise comparison results showed that the microscope group compared with the open group and laparoscopy group, the difference were statistically significant (P<0.05). Conclusions Microscopic surgery has less trauma, faster postoperative recovery, shorter operation cost and hospitalization time. Postoperative complications and recurrence, and improved semen quality are all superior to open spermatic vein ligation and single-hole umbilical laparoscopic surgery, it is a safe and effective way to treat varicocele.