Retinopathy of prematurity (ROP)occurs in the premature infant especially very low birth weight infants.It is an important reason which cause vision loss in children.The main pathological feature of ROP is retinal neovascularization.Vascular endothelial growth factor (VEGF) and insulin-like growth factor-1 (IGF-1) play a vital role in neovascularization by controlling the proliferation of vascular endothelial cells.In recent years many clinical studies have shown that intravitreal injection of anti-VEGF and increasing serum IGF-1 level of premature infants in early time is an effective method to prevent ROP.This article,according to the background of domestic and foreign relevant researches,reviews roles of VEGF and IGF-1 in ROP.

In recent years, many surgical innovations have been made from cervical cancer, such as trachelectomy, laparoscopic radical hysterectomy and surgery for advanced or recurrent cervical cancer, etc. The surgical innovations improve treatment effects, as well as postoperative quality of life.

The treatment for endometrial cancer refers to surgery,radiation and chemotherapy.Some disputable issues in the treatment are existing.Based on the recent clinical trial results,the choice of surgical modality,the role of lymphadenectomy,radiation and chemotherapy are present and discussed in this article.

This paper reports the treatment of 65 cases with Verruca Acuminate, 35 cases with the fulguration while 30 cases with the combined fulguration with injection poly i:c and both were compared. The results showed that the cure rate of the fulguration group was 68.6%, and that of the combined therapy group was 96,5%. The cure rate of the latter group revealed higher (P

Myasthenia gravis(MG)is an acquired autoimmune disease,which is mediated by nicotinic acetylcholine receptor(AChR)antibody,depends on cellular immunity and involves some complements.It mainly affects AChR on the postsynaptic membrane at the neuromuscular junction(NMJ).Various therapeutic methods have been used in the treatment of MG,but current therapeutic methods can not do well when used alone,and most current drugs have major side effects due to immunosuppression,We expect that novel therapies be discovered.

[Objective] To analyze the effect of operating and traditional Chinese drugs in treating appendicular abscess.[Methods] A study was made on 235 cases of appendicular abscess in acute period;strengthen post-operation support therapy,use antibiotics,meanwhile apply Chinese medicines.[Results] No case had stump fistula or intestinal fistula,among which,227 cases went out hospital after 7 days after operation;only 8 cases had incision infection,who also went out of hospital after 11~15 days.All cases were cured.[Conclusion] Operating combined with TCM in acute stage after operation was feasible,with satisfying result.

Objective] To analyze the effect of powder for ascending and descending on patients with different cough. [Method] The treatment group patients had still cough with conventional western medicine for two weeks, and initial treatment group patients had not any treatment after cough. All these patients were treated with powder for ascending and descending according to different Chinese traditional medicine syndromes cough. [Results] There were 49 patients, and 17 cases were the initial diagnosed group and 32 patients were the after treatment group. Patients with the improvement of the symptoms of cough and throat were effective in 15 cases(88.2%), while in patients with the improvement for sputum symptoms in initial group were 16 cases(94.1%), and 27 case(84.4%) in treatment group. It had no statistically significant difference between the two groups(χ2=0.006, P=0.940). Cough concrete improvement between the two groups showed no significant difference(χ2 =0.006, P =0.465). Between the two groups cough, throat and sputum symptoms overall improvement rate was 87.8%(43/49), no significant difference between the two groups(P>0.05). [Conclusion] Regardless of the treatment patients or untreated patients, treatment with powder for ascending and descending had good effect in improvement of the symptoms of cough, and the improvement of throat and sputum was effective, too.

Objective To discuss the curative effect and safety of the adjuvant therapy ( AT) of bifidobacteri-um bifidum-sine capsules to helicobacter pylori ( HP) positive peptic ulcer .Methods 76 HP infected peptic ulcer patients were selected and divided into the observation group and control group at random .The patients in control group were given traditional triple therapy of omeprazole ,amoxicillin and carat enzyme for 4 weeks,while the patients in observation group were given bifidobacterium bifidum-sine capsules(420mg) three times daily for 4 weeks.Clinical symptom remission,ulcer healing and HP clearance of patients in two groups were observed and compared .The inci-dence rate of drug adverse reaction ( DAR) during treatment period was observed ,and the recurrence rates of peptic ulcer within half a year and one year were followed up .Results The HP clearance rate of the observation group was significantly higher than control group (χ2 =4.21,P<0.05).The incidence rate of DAR of the observation group was 10.26%,which was significantly lower than 29.73%of the control group (χ2 =4.55,P<0.05).34 cases in the ob-servation group and 30 cases in the control group were healed ,these patients were followed up for half a year and one year,and the recurrence rate of peptic ulcer in observation group was significantly lower than that in control group (χ2 =4.51,5.23,all P<0.05).Conclusion The bifidobacterium bifidum-sine capsules combined with PPI triple therapy,can increase the eradication rate of HP ,reduce DAR and the recurrence rate of ulcer .

Objective] To trace the source of the original state of acupoints from classical TCM acupuncture documents, exposing breakthrough direction of acupuncture acupoints study. [Method] Based on classical TCM acupuncture documents, tease the interrelated thesis of factors concerning concept, origin, position, function and attribution of acupoints, explore the location and function of acupoints, and define the breakthrough direction of acupuncture acupoints study. [Result] In classical TCM acupuncture documents, the description to acupoints position is sketchy, while to that of function is in detail and develops continually. The function of acupoints concerns acupoint selection and correct position, on the other hand, it is closely related with application methods, concerning acupuncture time, Qi and blood function, acupuncture reinforcing and reducing, and stimulating amount, and other many factors;whether“bringing about the desired sensation”is very important to exert acupoints function. [Conclusion] Acupoints have many attributes, i.e. the location reflecting physiological condition, pathological state, disease treatment; just the different reactions of acupoints to physiological and pathological conditions, continual exploration and study, summarization and generalization, and repeated practice to functions of acupoints, promote the constant development of acupuncture science and clinic; the original state study of acupoints shall be the breakthrough direction of acupuncture acupoints research.

T lymphocytes play a very important role in tumor immunity, which recognize tumor antigenic peptide presented by MHC molecules on the surface of tumor cells through T cell receptor ( TCR) . Cytotoxic T lymphocytes kill tumor cells after recognizing antigenic peptide in the cleft of MHC class I molecules. It is now generally accepted that peptides naturally presented by a given MHC class I molecule have a specific motif which is referred to as MHC class I allele-specific consensus motif and that synthetic peptide corresponding to the identified naturally presented antigens exhibit remarkable activity in inducing T-cell responses. FBL-3 is a transplantable Friend virus-induced leukemia of B6 (H-2b) origin,which can induce the CTL against FBL-3 by immunizing B6 mice with atenuated FBL-3.Seven peptides were predicted as candidates of FBL-3 antigenic peptides in the light of H-2Db specific peptide binding motif and gag gene sequence of Friend virus. The synthetic peptides, named gagl to gag7, were obtainted. The results showed that CTL specific to gag3 could be induced by in vivo immunizing B6 mice with gag3 in IFA, but a primary T cell response could not be induced by in vitro immuniztion with the peptides. gag3 and gag5 could be recognized by specific CTL to FBL-3,because the CTLs obviously killed target cells (EL-4) pulsed with gag3 or gag5. Immunization with gag3 and gag5 could not induce an immune response to protect the subsequent challenge of FBL-3 in B6 mice which could be induced by immunizing B6 mice with parental FBL-3 tumor cells. This indicates these 7 synthetic peptides may not be the same antigens of the FBL-3.