1.The innovations of surgical treatment for cervical cancer
Cancer Research and Clinic 2008;20(6):363-365
In recent years, many surgical innovations have been made from cervical cancer, such as trachelectomy, laparoscopic radical hysterectomy and surgery for advanced or recurrent cervical cancer, etc. The surgical innovations improve treatment effects, as well as postoperative quality of life.
2.Roles of vascular endothelial growth factor and insulin-like growth factor-1 in retinopathy of prematurity
International Journal of Pediatrics 2014;41(6):590-593
Retinopathy of prematurity (ROP)occurs in the premature infant especially very low birth weight infants.It is an important reason which cause vision loss in children.The main pathological feature of ROP is retinal neovascularization.Vascular endothelial growth factor (VEGF) and insulin-like growth factor-1 (IGF-1) play a vital role in neovascularization by controlling the proliferation of vascular endothelial cells.In recent years many clinical studies have shown that intravitreal injection of anti-VEGF and increasing serum IGF-1 level of premature infants in early time is an effective method to prevent ROP.This article,according to the background of domestic and foreign relevant researches,reviews roles of VEGF and IGF-1 in ROP.
3.Some disputable issues in the treatment of endometrial cancer
Cancer Research and Clinic 2006;0(08):-
The treatment for endometrial cancer refers to surgery,radiation and chemotherapy.Some disputable issues in the treatment are existing.Based on the recent clinical trial results,the choice of surgical modality,the role of lymphadenectomy,radiation and chemotherapy are present and discussed in this article.
4.COMPARATIVE OBSERVATION OF TWO METHODS TREATING THE VERRUCA ACUMINATE
Journal of Chongqing Medical University 1986;0(02):-
This paper reports the treatment of 65 cases with Verruca Acuminate, 35 cases with the fulguration while 30 cases with the combined fulguration with injection poly i:c and both were compared. The results showed that the cure rate of the fulguration group was 68.6%, and that of the combined therapy group was 96,5%. The cure rate of the latter group revealed higher (P
5.Curative effect and safety of the adjuvant therapy of bifidobacterium bifidum-sine capsules to helicobacter pylori positive peptic ulcer
Wensheng WANG ; Yongliang WANG
Chinese Journal of Primary Medicine and Pharmacy 2014;(5):679-680,681
Objective To discuss the curative effect and safety of the adjuvant therapy ( AT) of bifidobacteri-um bifidum-sine capsules to helicobacter pylori ( HP) positive peptic ulcer .Methods 76 HP infected peptic ulcer patients were selected and divided into the observation group and control group at random .The patients in control group were given traditional triple therapy of omeprazole ,amoxicillin and carat enzyme for 4 weeks,while the patients in observation group were given bifidobacterium bifidum-sine capsules(420mg) three times daily for 4 weeks.Clinical symptom remission,ulcer healing and HP clearance of patients in two groups were observed and compared .The inci-dence rate of drug adverse reaction ( DAR) during treatment period was observed ,and the recurrence rates of peptic ulcer within half a year and one year were followed up .Results The HP clearance rate of the observation group was significantly higher than control group (χ2 =4.21,P<0.05).The incidence rate of DAR of the observation group was 10.26%,which was significantly lower than 29.73%of the control group (χ2 =4.55,P<0.05).34 cases in the ob-servation group and 30 cases in the control group were healed ,these patients were followed up for half a year and one year,and the recurrence rate of peptic ulcer in observation group was significantly lower than that in control group (χ2 =4.51,5.23,all P<0.05).Conclusion The bifidobacterium bifidum-sine capsules combined with PPI triple therapy,can increase the eradication rate of HP ,reduce DAR and the recurrence rate of ulcer .
6.Analysis of Effect of Powder for Ascending and Descending on Treated or Initial Treatment Patient with Cough
Journal of Zhejiang Chinese Medical University 2016;40(7):549-550,559
Objective] To analyze the effect of powder for ascending and descending on patients with different cough. [Method] The treatment group patients had still cough with conventional western medicine for two weeks, and initial treatment group patients had not any treatment after cough. All these patients were treated with powder for ascending and descending according to different Chinese traditional medicine syndromes cough. [Results] There were 49 patients, and 17 cases were the initial diagnosed group and 32 patients were the after treatment group. Patients with the improvement of the symptoms of cough and throat were effective in 15 cases(88.2%), while in patients with the improvement for sputum symptoms in initial group were 16 cases(94.1%), and 27 case(84.4%) in treatment group. It had no statistically significant difference between the two groups(χ2=0.006, P=0.940). Cough concrete improvement between the two groups showed no significant difference(χ2 =0.006, P =0.465). Between the two groups cough, throat and sputum symptoms overall improvement rate was 87.8%(43/49), no significant difference between the two groups(P>0.05). [Conclusion] Regardless of the treatment patients or untreated patients, treatment with powder for ascending and descending had good effect in improvement of the symptoms of cough, and the improvement of throat and sputum was effective, too.
7.Targeted therapy in the present status and prospect of ovarian cancer
Cancer Research and Clinic 2011;23(9):577-580
Despite multimodel chemotherapy after successful surgical cytoreduction for ovarian cancer,disease recurrence continues to be problematic.Therefore,exploring new treatment strategy has already become urgent matter of the moment. Biological targeted therapies have been studied to overcome chemotherapy resistance.The most promising one at this time is bevacizumab.Results from phase Ⅱ and phase Ⅲ trials were excited.Deeper understanding of biologic pathway in ovarian cancer,and more biologic targets undergoing clinical trial will develop a new world for the treatment of ovarian cancer.
8.The detection of cytokines in porcine-human mixed lymphocyte culture
Chinese Journal of Organ Transplantation 1997;18(3):158-160
In order to explore the relationship between xenograft rejection and cytokines, the proliferative responses and cytokine contents from human lymphocyte were detected in porcinehuman mixed lymphocyte culture (MLC) and compared with human allo-MLC. The results showed that the proliferative responses in the former was equal to or stronger than that in the latter, and the kinetics of IL-2 and IFN-Y in both supernatants were similar but the peak of IL-4 from the former was higher than that from the latter (P<0.05). This suggests that cytokines are likely to play roles in porcine-human MLC.
9.Ultrasound soft markers and fetal cardiac structural assessment at 11-14 weeks
Yandong YANG ; Yongliang ZHANG
Chinese Journal of Obstetrics and Gynecology 2014;49(3):188-192
Objective To evaluate the detection rate of congenital heart defect (CHD) during the first trimester screening for chromosomal abnormalities,the role of ultrasound soft markers including increased nuchal translucency (NT),tricuspid regurgitation (TR) and abnormal ductus venosus (DV) flow in the screening for cardiac anomalies was also investigated.Methods From January 2009 to January 2012,4 673 fetuses were scanned at 11-14 weeks at Department of Fetal Medicine,the First Affiliated Hospital of Jinan University.The ultrasound findings and follow up outcomes were recorded,False-positive rate of different first-trimester ultrasound markers for the detection of CHD was calculated,sensitivity of the markers for all major CHD was calculated as well.Results There was a significant association between major CHD and first trimester ultrasound markers.(1) Overall findings:among the 4 673 fetuses,31 fetuses were diagnosed CHD prenatally,17,12 and 2 of which were detected in the first,second and third trimester,respectively.In 22 of the 31 CHD cases,invasive procedure was performed,fetal karyotype was abnormal in 12 cases,including triosmy 21 (5 cases),trisomy 18 (2 cases),trisomy 13 (2 cases),Turner syndrome (2 cases) and pericentric inversion of chromosome 9 (1 cases).(2) NT measurement and prenatal detected CHD:in 4 673 cases,NT measurement between 95th-99th percentile were present in 206 (4.41%),5 cases were diagnosed CHD prenatally,in 4 of 5 cases were detected in first trimester; NT measurement < 95th percentile were present in 4 430(94.80%),16 cases were diagnosed CHD prenatally,in 5 of 16 cases were detected in first trimester; NT measurement > 99th percentile (> 3.5 mm) were present in 37 (0.79%,37/4 673),10 cases were diagnosed CHD prenatally,in 8 of 10 cases were detected in first trimester.(3) TR and inverted a-wave at the DV and prenatal detected CHD:among 4 673 cases,TR or inverted a-wave at the DV were present in 51 (1.09%),98 (2.10%) respectively.TR was present in 8 of 31 CHD cases,inverted a-wave at the DV was present in 7 of 31 CHD cases.(4)Sensitivity of different first trimester ultrasound markers for detection of major CHD cases:in 31 CHD cases diagnosed prenatally,23 eased were defined as major CHD.Sensitivity of at least one of the ultrasound narkers,NT measurement between 95th-99th percentile,> 99th percentile(> 3.5 mm),TR or inverted a-wave at the DV for detection of major CHD eases was 74% (17/23),22% (5/23),39% (9/23),35% (8/23),30% (7/23),respectively.(5) Specificity of different first trimester ultrasound markers for detection of CHD cases:specificity of NT measurement between 95th-99th percentile,> 99th percentile(> 3.5 mm),TR or inverted a-wave at the DV for detection of major CHD cases was 4.30% (201/4 673),0.58% (27/4 673),0.92% (43/4 673),1.94% (91/4 673).Conclusions Routine first trimester soft markers for chromosomal abnormalities screening combined with cardiac assessment can detect quite a number of major heart defects.Increased NT,TR and abnormal DV flow can be important indicators for echocardiography,which is favorable to early prenatal diagnosis of CHD.
10.Effect of Grape Seed Proanthocyanidin on Growth Associated Protein-43 through Extracellular Signal Regulated Kinase 1/2 Pathway in Rats with Brain Radiation Injury
Chinese Journal of Rehabilitation Theory and Practice 2015;(12):1397-1401
Objective To observe the effect of grape seed proanthocyanidin extract (GSPE) on growth associated protein-43 (GAP-43) through extracellular signal regulated kinase 1/2 (ERK1/2) pathway in rats with brain radiation injury. Methods 72 3-month male Sprague-Dawley rats were divided into control group (n=18), model group (n=18), high dose GSPE group (n=18) and low dose GSPE group (n=18). The brain radiation injury models were established by linear accelerator irradiation with 22 Gy. The learning ability was assessed with shuttle box. The morphological changes of neurons in hippocampus were observed with HE staining;the expression of GAP-43 was de-tected by RT-PCR; and the expression of phosphorylated ERK1/2 was detected by Western blotting. Results Compared with the model group, the active avoidance reaction rate in the shuttle box test increased and the passive avoidance latency shortened in GSPE groups (P<0.001); the nerve cell morphological injury reduced and the expression of GAP-43 mRNA and phosphorylated ERK1/2 increased in the GSPE groups (P<0.001), especially in the high dose GSPE group (P<0.001). The GAP-43 mRNA level positively correlated with phosphory-lated ERK1/2 level in the model group (r=0.764, P<0.001), the low dose GSPE group (r=0.814, P<0.001) and the high dose GSPE group (r=0.822, P<0.001). Conclusion GSPE could promote the expression of GAP-43 through ERK1/2 pathway in rats, and prevent the brain from radiation injury.