Objective To evaluate the clinical anesthetic efficacy of a combination of propofol and remifentanil for ultrasound-guided transvaginal oocyte retrieval.Pharmacodynamic (PD) model was established and its characteristics were analyzed based on the simulated concentrations of propofol and remifentanil in respective pharmacokinetic models, so as to guide further study.Methods Forty-two female patients undergoing transvaginal oocyte retrieval were divided into groups PR15 (n=24) and PR10 (n=18), who were received intravenous bolus of remifentanil 1.5 μg/kg + propofol 1.5 mg/kg and remifentanil 1.0 μg/kg+propofol 1.0 mg/kg, respectively.The anesthesia quality evaluation was based on the following indicators: onset time (loss of eyelash reflex), recovery time of orientation, the incidence of hypoxemia (SpO2 < 92%) and adverse reactions.Nonlinear mixed-effects model was used to evaluate the time courses of the simulated propofol and remifentanil concentrations-effect and to establish the PD model with NONMEM software.Results The time of recovering orientation in the patients of group PR10 was significantly faster compared with the patients in group PR15;the time of loss of eyelash reflex , incidence of hypoxemia (12.5% vs 16.7%) and cough (16.7% vs 11.1%) had no significant differences between the both groups.With the final PD model, the estimated parameters as following: EC50 of propofol and remifentanil for effective sedation and analgesia were 1.71 μg/ml and 2.57 ng/ml, respectively.EC95 of propofol and remifentanil for effective sedation and analgesia were 4.30 g/ml and 4.57 ng/ml, respectively.The effect site concentration of propofol 1 mg/kg was lower than EC50, but the effect site concentration of 1.5 mg/kg was higher than EC50.The peak effect site of 1.0 μg/kg and 1.5 μg/kg remifentanil was higher than EC50, and 1.5 μg/kg concentration was close to EC95.Conclusion Based on patients' recovery time, propofol 1.0 mg/kg combined with fentanyl 1.0 μg/kg is appropriate in patients undergoing transvaginal oocyte retrieval.

Objective To investigate methods and results of endovascular treatment in TASC (Ⅱ) D-type femoral artery occlusion. Methods From January 2012 to May 2013, 26 cases (26 branches) of superficial femoral artery occlusion with endovascular treatment of TASC (Ⅱ) D-type superficial femoral artery occlusion were retrospectively reviewed. The effi-cacy was evaluated through ABI, CTA, DSA and symptoms improved. Results 26 branches were treated with endovascular methods. Technical success rate was 80.7%(21/26), including 13 branche with stent implantation, 6 branches with Silver-hawk atherectomy and 2 branches with Viabahn stent implantation. All patients were followed up for a mean period of (10.3 ± 1.2)months, primary patency rates at 6 months were 69.2%in stent group, 66.7%in Silverhawk atherectomy group and 100%in Viabahn stent group. Conclusion Endovascular treatment of TASC (Ⅱ) D-type femoral artery occlusion can lead to satisfactory short term patency rates, and Viabahn stent is the latest treatment.

Objective: To investigate the effects of aerobic exercise and nutritional education on blood lipids, physical fitness and exercise behavior among students with high cholesterol level. Methods: A total of 140 male college students with total cholesterol higher than 200 mg/dl were randomly divided into cycling + nutrition education (BE) group; control group (C). The BE group received 6-weeks intervention (3 times a week, 60 minutes each time, exercise intensity of 50%-70% HRR and 60 minutes of nutrition education per week). Blood lipids, physical fitness, daily dietary intake, and exercise behavior before and after intervention was assessed. Results: BMI and waist-to-hip ratio in the BE group were significantly lower than those in the group C[(25.57±1.77) kg/m2 vs (28.88±2.10) kg/m2], [(0.81±0.03) vs (0.87±0.06)]; Cardiopulmonary fitness was significantly better than group C [(54.45 ± 5.31) vs (50.00 ± 5.29)]. The level of TC of group C was significantly higher than that of group BE [(229.90±25.63) mg/dL vs (195.90±34.79) mg/dL], and the HDL-C of group BE was significantly better than group C [(70.30±8.06) mg/dL vs (58.60±10.42) mg/dL]. The conscious activity of the group BE was significantly better than that of the group C[(78.90±4.58) vs (74.10±5.48)], and the conscious dyskinesia in the group C was significantly higher than that in the group BE[(57.30±5.54) vs (51.40±4.87)], group BE The exercise self-efficacy was better than that of group C [(66.80±8.75) vs (57.10±9.09)], and the difference was statistically significant(t=5.33，4.11，6.22，P<0.05). The daily intake of potato, vegetables, fruits, livestock and poultry, fish and shrimp, eggs, milk and beans in the group BE was in a reasonable range, which was significantly better than that before intervention and group C(P<0.01). Conclusion In summary, intervention combined with moderate-intensity exercise and nutrition education shows significant effects in improving cardiopulmonary fitness, HDL-C level, and lowering BMI, waist-to-hip ratio, and total cholesterol value; 6-week exercise intervention improves self-conscious sports interests, conscious movement disorders and cognitive self-efficacy; nutrition education intervention helps guide college students to take reasonable dietary behavior and reasonable intake of food.