Objective To summarize the causes of patients with fever of unknown origin (FUO) and to analyze the relationship between infectious diseases and FUO,in order to provide envidence for experiential therapy.Methods Clinical data of 374 FUO inpatients at He'nan Provincial People's Hospital from June 1,2009 to May 31,2013,including gender,age,diagnosis and department were analyzed retrospectively.Results Three hundred and twenty-seven cases among the overall 374 FUO patients (87.4％) were eventually etiological diagnosed based on supplementary examinations or diagnostic treatment.As for the causes of fever,209 were infection,accounting for 55.9％,among which 78 cases (20.9％) were diagnosed with tuberculosis,23 cases (6.1％) brucellic diseases,19 cases (5.1％) rickettsia infection.Meanwhile,the noninfectious diseases,such as connective tissue diseases (47,12.6％),hematonosis (37,9.9％) as well as the solid tumors (13,3.5％) also constituted considerable shares of the causes for FUO.However,the causes of 47 cases (12.6％) were not identified before discharge.Conclusions Infectious diseases are the main cause of FUO,in which tuberculosis accounts for the majority.Brucellosis and rickettsia infection also account for a considerable proportion.The causes of most FUO cases could be identified through detailed analysis of clinical data and supplemental examinations.

Objective? To explore the effects of knowledge-attitude-practice(KAP) intervention model on the cognition and behavior of prevention and control of multidrug-resistant organism (MDRO) infection of medical staff in intensive care unit (ICU). Methods? By convenience sampling, 80 ICU medical staff working in He'nan People's Hospital from August 2017 to March 2018 were selected as the participants in this study, and their knowledge and behavior of MDRO infection prevention and control were intervened based on the KAP model. The scores of KAP Questionnaire on MDRO infection prevention and control, relevant knowledge, attitude, compliance of MDRO infection prevention and control among the 80 ICU medical staff and the incidence of patients' MDRO infection before and after intervention were compared. Results? After intervention, the ICU medical staff's score in KAP questionnaire, relevant knowledge awareness rate, and attitude holding rate about MDRO infection prevention and control all improved compared with those before intervention (P＜ 0.05). After intervention, the compliance score of MDRO infection prevention and control behavior was higher than before, and the difference was statistically significant (P＜0.05). After intervention, the incidence of MDRO in ICU patients was 5.08%, lower than 12.20% that before intervention with statistical difference (P＜ 0.05). Conclusions? KAP intervention model can effectively improve the cognition level of prevention and control of MDRO infection in ICU medical staff, promote the enthusiasm for MDRO infection-related attitudes, and improve the behavior compliance of MDRO infection prevention and control,thus improving the prevention and control effects as a whole.