Objective:To explore of the medical and economic coordination development in provincial regions of China and its spatial-temporal evolution so as to provide new thought for researching the relationship between medical and economic growth.Methods:Based on physics concept and retated research,coordination development model was built to analyze the medical and economic coordination development in provincial regions of China.The exploratory spatial data analysis was used to analyze its spatial-temporal evolution.Results:There were certain progresses on medical and economic coordination development in provincial regions of China.Transition class regions were in the majority,while coordinated and unbalanced class regions were in the minority.The medical and economic coordination development degrees were agglomerated spatially.Both high and low values of medical and economic coordination development degrees are agglomerated obviously.Hot and sub-hot regions were mainly distributed in eastern and central China,while cold and sub-cold regions were mainly distributed in western China.Conclusion:Coordination development model could be applied for researching the medical and economic coordination development in provincial regions of China which provided new basis for further research on the relationship between medical and economic growth.

A protein designated as Flammulina Velutipes (FV) protein was isolated from the cultured mycelium of FV and purified to homogeneity by CM cellulose CM 52 and gel filtration chromatography. The molecular weight of FV protein were found to be 1.75?10~4u with pI 4.3. Amino acid analysis of FV protein indicated the presence of 14 kinds of amino acids, especially rich in Glu, Asp and Thr.Potent inhibitory effect of FV protein on thrombus formation, in the blood was observed in vitro when rats were given intravenously. The length of thrombus was shortened and the dry weight of the thrombus decreased significantly at the dose of 7.5?10~(-7) mol/kg. Thrombus formation was completely inhibited at the dose of 10~()-8 mol/kg. The IC_(50) was found to be 4.4?10~(-7) mol/kg. FV protein was shown to inhibit collegen induced aggregation of rat platelets both in vitro and in vivo. Its concentration for complete inhibition in vitro was 7.5?10~(-5) mol/L. The IC_(50) was found to be 4?10~(-5)mol/ L. However, FV protein dose of 1.25?10~(-5) mol/kg was required for 60% inhibition in vivo

Object To isolate and identiified the chemical constituents from the EtOAc soluble fraction of the rhizome of Semiliquidambar cathayensis Chang with anti inflammatory activity Methods The EtOAc soluble fraction of anti inflammatory activity was determined on the basis of the mouse ear irritant assay by croton oil The chemical constituents were isolated by silica gel column chromatography, and their structures were identiified by IR, MS and NMR spectroscopic methods including HMQC and HMBC experiments Results Four oleanolic acid derivatives, oleanolic acid, 3 oxo olean 12 en 28 oic acid 2?, 3? dihydroxyolean 12 en 28 oic acid, 2?, 3?, 23 trihydroxyolean 12 en 28 oic acid (arjunolic acid); three ellagic acid derivatives, ellagic acid 3, 3′ dimethylether, ellagic acid 3, 3′, 4 trimethylether, and ellagic acid 4 O ? D xylopyranoside 3, 3′ dimethylether, together with ? sitosterol and octadecylic acid were obtained and identified Conclusion All the nine compounds were isolated for the first time from the title plant

Objective To summarize the experience of surgical techniques and prevention of postoperative complications of giant intracranial meningiomas.Methods The clinical data of 32 patients with giant intracranial meningiomas were analyzed retrospectively.The cause of operative complications was analyzed and the experience was summarized.Results The meningiomas Simpson grade Ⅰ resection was 16 is.cases,grade Ⅱ resection was 9 cases,grade Ⅲ resection was 5 cases,grade Ⅳ resection was 2 cases.The postoperative complications included anemia was 14 cases,intracranial hemorrhage was 2 cases,severe cerebral edema was 4 cases,epilepsy was 3 cases,cerebral infarction was 2 cases,and recovered well after treatment.Conclusion Good surgical technique,advanced prevention of surgical complications,early diagnosis and treatment can significantly improve the prognosis.

By using a combination of various chromatographic techniques including column chromatography over silica gel and Pharmadex LH-20 and reversed-phase HPLC, two minor new compounds, labda-12, 14-dien-6beta, 7alpha, 8beta, 17-tetraol (1), 2, 3-cis-6-acetyl-5-hydroxy-2-(hydroxymethylvinyl)-2, 3-dihydrobenzofuran-3-ol angelate (2), and a minor new natural product 6-methoxy-4-methyl-3, 4-dihydro-2H-naphthalen-1-one (3) have been isolated from an ethanolic extract of Heteroplexis micocephala. Their structures were elucidated with spectroscopic data analysis including 2D NMR experiments.

Ten compounds were isolated from the 70% ethanol extract of linseed meal (Linum usitatissimum L) through a combination of various chromatographic techniques, including silica gel, macroporous adsorbent resin, Sephadex LH-20, and preparative HPLC. On the basis of spectroscopic data analysis, they were elucidated as 1-methylethyl-2-O-beta-D-glucopyranosyl-(1" --> 6')-beta-D-glucopyanoside (1), linustatin (2), neolinustatin (3), lotaustralin (4), linamarin (5), deoxyguanosine (6), deoxyadenosine (7), (+)-pinoresinol-4'-O-beta-D-glucopyranoside (8), 4-O-beta-D-glucopyranosylvanillyl alcohol (9) and tachioside (10), separately. Among them, compound 1 is a new compound, and compounds 6, 8 and 10 were isolated from the linseed meal for the first time.

Objective To study the chemical constituents from the stem bark of Daphne giraldii. MethodsThe chemical constituents in the alcoholic extract from the stem bark of D. giraldii were isola-ted and purified using liquid/liquid extraction and silica gel column chromatography. The structures of the isolated compounds were determined on the basis of NMR, and mass spectra. ResultsSeven compounds were isolated from the alcohol extract. Their structures were identified as E-octadecyl caffeinate (Ⅰ), (+)-nortrachelogenin (Ⅱ), daphnoretin (Ⅲ), daphneticin (Ⅳ), 7, 8-dihydroxy coumarin (Ⅴ), 7-hydroxy coumarin (Ⅵ), and luteolin (Ⅶ) on the basis of 1H-NMR, 13C-NMR, and MS. ConclusionCompound Ⅰ is a new one. Compounds Ⅱ, Ⅳ, and Ⅶ are isolated from the title plant for the first time.

Object To isolate and identify the biflavonoids from the stem bark of Daphne giraldii Nitsche. Methods The flavonoids were isolated and purified by column chromatography on silica gel and Sephadex LH-20. Their structures were determined by spectroscopic methods, including IR, 1HNMR, 13 CNMR, HMBC and FAB-MS.Results Four biflavonoids daphnodorins A-D 1 (Ⅰ-Ⅳ) were isolated from the stem bark of D. giraldii. Conclusion The above four biflavonoids were isolated from the title plant only.

Objective To investigate the impacts of fiducial tracking and X-sight tracking on the short-term therapeutic effect of cybernikife in the treatment of lung cancer.Methods Retrospective analysis was performed on 64 lung cancer patients (72 lesions),including 40 primary tumor patients (41 lesions) and 24 metastatic tumor patients (31 lesions),who were treated with cyberknife.Fiducial tracking was used for 45 lesions,while X-sight tracking was used for 27 lesions.The planning target volume was covered by 70％-94％ (median 80％) isodose contour.The irradiation dose was 60 Gy/3 fractions.The relationship between short-term therapeutic effect and tracking method was determined.Results Overall,the lesions undergoing fiducial tracking showed significantly higher response rate than those undergoing X-sight tracking (93％ vs.74％,x2 =6.84,P=0.033),and so was in lower lung lesions (15％ vs.7％,x2 ＝7.18,P=0.028).But the two tracking methods achieved similar effects in upper lung lesions (28％ vs.12％,x2 =2.36,P =0.310).In the lesions with treatment volumes smaller than 15 cm3,the fiducial tracking achieved significantly higher response rate than the X-sight tracking (25 ％ vs.12％,x2 =6.53,P =0.038),but the two tracking methods achieved similar effects in the lesions with treatment volumes not smaller than 15 cm3 (17％ vs 8％,x2 =1.57,P =0.460).Overall,the lesions undergoing X-sight tracking had significantly highertreatment failure rate than fiducial tracking (1 9 ％ vs.2 ％,x2 =6.33,P =0.021).Conclusions Different tracking methods may lead to different therapeutic effects of cyberknife in the treatment of lung cancer,which are related to lesion location and treatment volume.

Objective To evaluate quantitatively the extra absorbed dose generated by image guided system of the Cyberknife.Methods The exposure parameters and the average frequency of images acquisition during the treatments with G3 Cyberknife in 300 cases with various tumor locations and tracking modes were collected for analysis ;The measurements of the absorbed doses in the phantom with 5 points after single exposure generated by image guided system in various exposure parameters were performed with equipment of phantom CIRS Model 002LFC and 002 PRA with ion chamber PTW30010 included.Based on the data we collected andmeasured,the conclusion of how much extra absorbed dose generated by image guided system of Cyberknife the patients received during Cyberknife treatments was drawn.Results With an average fractions of 3.94(the median was 4),the average exposure frequency was 36.5 times for static tracking per patient per fraction,while it was 49.2 times for dynamic tracking.The experimental results with various exposure parameters,positions and tissue densities showed that the minimum absorbed dose after single exposure was 0.5 μGy,while the maximum was 385 μGy.Conclusions The image guided system of the Cyberknife can induce quite low absorbed dose in patient,while providing all three types of image guided function.