1.Etiology and differential diagnosis of hypertension in children
Chinese Journal of Applied Clinical Pediatrics 2015;(13):965-967
Hypertension in children and adolescents is defined as systolic blood pressure(SBP)and/ or dias-tolic blood pressure(DBP)≥95th percentile for age,gender and height,on at least 3 occasions. Primary hypertension is more common among children of older age or adolescents,while secondary hypertension accounts for more cases for younger children. Among causes of secondary hypertension,renovascular diseases,renal parenchymal diseases,cardio-vascular diseases,and endocrine diseases are common. An initial evaluation can be reached after history taking and physical examination,to decide whether it should be primary or secondary hypertension. Laboratory tests and procedures can further confirm the classification and etiology. There is an increase in prevalence of hypertension in children and adolescents,and an in - time diagnosis and evaluation of hypertension is important to help patients receive a better management of their conditions.
2.Pharmaceutical Care in Drugstores from the Perspective of Drug Administration
Yongbing NI ; Wenlong HUANG ; Yongfa CHEN
China Pharmacy 2005;0(13):-
OBJECTIVE: To explore approaches for further development of pharmaceutical care in retail drugstores by strengthening drug administration. METHODS: The main problems occurred in pharmaceutical care were analyzed from the perspective of drug administration. RESULTS & CONCLUSIONS: The main problems occurred in pharmaceutical care were the absence of laws and regulations related to pharmaceutical care,misalignment between the access criteria for retail pharmacy and the necessary conditions for pharmaceutical care. The development of pharmaceutical care could be promoted by perfecting current law system,enhancing the access criteria for running retail drugstore,and strengthening drug administration etc.
3.Prognostic factors of surgical treatment for elderly patients with non-small cell lung cancer
Kanqiu JIANG ; Yongyue QIAN ; Yongbing CHEN ; Weihua XU
Chinese Journal of Geriatrics 2016;35(3):260-262
Objective To analyze prognostic factors of surgical treatment for elderly patients with non-small cell lung cancer,in order to provide a theoretic basis for improving the prognosis of patients with non-small cell lung cancer.Methods Clinical data of 145 elderly patients with non-small cell lung cancer who had received surgical treatment at our hospital from January 2012 to September 2012 were retrospectively analyzed.The survival rates of patients were investigated.Results The median survival time was 31.5 months,and 1-year,2-year and 3-year survival rates were 61.4%,45.5% and 40%,respectively.Single factor analysis showed that lesion size,number of metastatic lymph nodes,clinical stage,pathological type and radiotherapy were among the factors affecting prognosis.Multiple COX regression analysis showed that a lesion size >3cm,number of lymph nodes with metastasis > 2 and pathological type were independent risk factors for patient prognosis,and radiotherapy was a protective factor for prognosis.Conclusions Surgical treatment has good curative effects on non-small cell lung cancer in elderly patients.Lesion size,number of lymph nodes with metastasis,pathological type and radiotherapy are important factors affecting prognosis,and can be used for prognosis assessment.
4.External drainage of full pancreatic juice decreases pancreatic leakage in pancreatoduodenectomy
Yongbing CHEN ; Banglv JU ; Xiaoqing SHEN ; Conghui YU
International Journal of Surgery 2014;41(6):380-382
Objective To summarize the results of a new pancreaticojejunostomy technique designed to decrease incidence of pancreatic leakage in pancreatoduodenectomy.Methods The clinical data of 11 cases of pancreatoduodenectomy using remnant pancreatico-jejunum end-to-end anastomosis with external drainage of full pancreatic juice was analyzed retrospectively.Briefly,5-0 bioabsorbable suture was penetrated through the pancreatic stump and stent and then circulated the pancreatic stump for 2 circles and ligated.Octreotide was not administered in any cases post-operation.Results The operation was simple and timespared.Neither pancreatic leakage nor postoperative bleeding occurred in the cases.From 4 months to 3 years following operation,no other complications were found in all cases.Conclusions The method was safe,feasible and effective to decrease incidence of pancreatic leakage in pancreatoduodenectomy.
5.Effect of video-assisted thoracoscopic operation on postoperative cardiopulmonary complications in elderly patients with non-small cell lung cancer
Weihua XU ; Yongbing CHEN ; Kanqiu JIANG ; Yongyue QIAN ; Yong PENG
Chinese Journal of Geriatrics 2015;34(5):510-511
Objective To compare the incidence of cardiopulmonary complications between treatment of video assisted thoracoscopic operation and traditional thoracotomy operation in elderly patients with non-small cell lung cancer.Methods 122 cases of elderly patients with non small cell lung cancer were treated in our hospital from Mar 2010 to Jun 2014,and randomly divided into observation group (therapeutic lobectomy by video assisted thoracoscopic operation) and control group (therapeutic lobectomy by traditional thoracotomy operation) (n=61,each).The postoperative cardiopulmonary complications and relevant indexes of cardiopulmonary function were analyzed and compared between the two groups.Results Before operation,there was no significant difference in the relevant indexes of cardiopulmonary function between the two groups (P>0.05).After operation,the forced expiratory volume in one second (FEV1) and maximal ventilatory volume (MMV) were higher and the heart rate was lower in observation group than in control group (t=3.682,2.243,5.677,all P<0.05).The incidence of cardiopulmonary complication was lower in observation group than in control group (13.1% vs.27.9%,x2 =4.075,P=0.044).Conclusions Video assisted thoracoscopic operation is better for the recovery of cardiopulmonary function,and can reduce cardiopulmonary complication in elderly patients with non-small cell lung cancer.
6.Effect of primarily cultured human lung cancer-associated fibroblasts on radiosensitivity of lung cancer cells
Xiaoqin JI ; Jiang JI ; Yongbing CHEN ; Fang SHAN ; Xueguan LU
Chinese Journal of Radiation Oncology 2014;23(2):169-172
Objective To investigate the effect of human lung cancer-associated fibroblasts (CAF) on the radiosensitivity of lung cancer cells when CAF is placed in direct contact co-culture with lung cancer cells.Methods Human lung CAF was obtained from fresh human lung adenocarcinoma tissue specimens by primary culture and subculture and was then identified by immunofluorescence staining.The CAF was placed in direct contact co-culture with lung cancer A549 and H1299 cells,and the effects of CAF on the radiosensitivity of A549 and H1299 cells were evaluated by colony-forming assay.Results The human lung CAF obtained by adherent culture could stably grow and proliferate,and it had specific expression of α-smooth muscle actin,vimentin,and fibroblast activation protein,but without expression of cytokeratin-18.The plating efficiency (PE,%) of A549 cells at 0 Gy irradiation was (20.0 ± 3.9) % when cultured alone versus (32.3 ± 5.5) % when co-cultured with CAF (t =3.16,P < 0.05),and the PE of H1299 cells at 0 Gy irradiation was (20.6 ± 3.1) % when cultured alone versus (35.2 ± 2.3) % when co-cultured with CAF (t =6.55,P <0.05).The cell survival rate at 2 Gy irradiation (SF2) of A549 cells was 0.727 ±0.061 when cultured alone versus 0.782 ± 0.089 when co-cultured with CAF (t =0.88,P > 0.05),and the SF2 of H1299 cells was 0.692 ±0.065 when cultured alone versus 0.782 ± 0.037 when co-cultured with CAF (t =2.08,P >0.05).The protection enhancement ratios of human lung CAF for A549 cells and H1299 cells were 1.29 and 1.25,respectively.Conclusions Human lung CAF reduces the radiosensitivity of lung cancer cells when placed in direct contact co-culture with them,and the radioprotective effect may be attributed to CAF promoting the proliferation of lung cancer cells.
8.Hepatic arterial injection of recombinant adenovirus microspheres carrying antisense multidrug resistance-associated protein gene for hepatocellular cancer in rats
Xiaobo WANG ; Shaohong YU ; Lunan YAN ; Yongbing CHEN
Chinese Journal of General Surgery 1993;0(01):-
Objective To evaluate recombinant adenovirus microspheres encapsulated with antisense MRP(as-mrp) on reversion of hepatocellular carcinoma.Methods The rats were divided randomly into 5 groups:control group;hepatic arterial injection of normal saline group,microspheres carrying no viruses group,rAdV carrying as-mrp group,and microspheres with encapsulation of as-mrp rAdV(MER) group.The theraputic effect were observed.Results The tumor growth inhibition and the mean life time in MER group were superior to than of other 4 groups(P
9.Experiences of reducing complications of post-pancreaticoduodenectomy (report of 62 cases)
Conghui YU ; Hongfeng NIE ; Yongbing CHEN ; Junbo YAO ; Ronghua YANG ; Jianfei WANG
International Journal of Surgery 2012;39(2):94-97
ObjectiveTo discuss the treatment of complications post-pancreticoduedenectomy by reviewing the experiences from 62 cases.MethodsSixty-two cases of pancreticoduedenectomy from March 2001 to April 2011,mean age 59.3 ±4.1 years,were reviewed.All cases were divided into early group 24 cases and recent group (38 cases) by the difference in following aspects:perioperative management,the way of pancreatic bowel anastomosis and material choice,the vessels management,materials using in preventing leakage and bleeding.The differences in leakage,bleeding,infection,the stomach retention,biliary infections,liver abscess and incision infection in two groups were compared.ResultsThe early group showed pancreatic leakage in 10 cases,bleeding in 4 cases,celiac infection in 10 cases,gastric retention in 9 cases,biliary infections in 11 cases,liver abscess in 6 and infection of incision in 7 cases,respectively.Recent groups were in 4,0,0,0,1,2 and 3 cases,respectively.The comparisons showed the complications had reduced significantly in recent group than in the early group (x2 =77.08,P < 0.001 ).ConclusionsMinimally invasive and high quality materials use,strengthening the perioperative management are the effective measures to reduce the postoperative complications.
10.Neoadjuvant Treatment of Borderline Resectable Pancreatic Cancer
Zegang CHEN ; Yongbing WANG ; Tao OU
Cancer Research on Prevention and Treatment 2022;49(9):982-986
Borderline resectable pancreatic ductal adenocarcinoma accounts for approximately 20% of newly diagnosed pancreatic cancer patients. This type of adenocarcinoma is between resectable and unresectable. It has a high degree of heterogeneity and features in anatomy, biology, and physical condition. The biological characteristics of invasiveness determine that, rather than direct surgery, neoadjuvant therapy should be primarily given to patients to achieve R0 resection and avoid early postoperative recurrence. However, this treatment model is still controversial. According to the latest research on this topic, the full text summarizes the definition of BR-PDAC, resectable evaluation, neoadjuvant treatment selection and evaluation, surgical results after neoadjuvant therapy, and the efficacy of adjuvant therapy after neoadjuvant therapy.