3.The role of pathologists in the target therapy of gastrointestinal tumors.
Chinese Journal of Pathology 2010;39(7):433-435
Anoctamin-1
;
Antineoplastic Agents
;
administration & dosage
;
Benzamides
;
Biomarkers, Tumor
;
metabolism
;
Chloride Channels
;
Drug Delivery Systems
;
methods
;
Gastrointestinal Neoplasms
;
genetics
;
metabolism
;
pathology
;
therapy
;
Gastrointestinal Stromal Tumors
;
genetics
;
metabolism
;
pathology
;
therapy
;
Humans
;
Imatinib Mesylate
;
Indoles
;
administration & dosage
;
Membrane Proteins
;
metabolism
;
Neoplasm Proteins
;
metabolism
;
Piperazines
;
administration & dosage
;
Proto-Oncogene Proteins c-kit
;
metabolism
;
Pyrimidines
;
administration & dosage
;
Pyrroles
;
administration & dosage
;
Receptor, Platelet-Derived Growth Factor alpha
;
genetics
;
metabolism
;
Vascular Endothelial Growth Factor A
;
metabolism
4.On Harmonious Physician-Patient Relationship and Hospital Culture Construction
Chinese Medical Ethics 1995;0(02):-
A harmonious physician-patient relationship is closely correlated with hospital culture construction.This paper explores the correlation from the perspectives of roles in building up decent fame of hospitals,promoting the construction of medical ethics,cultivating a fine humanistic medical atmosphere,strengthening the social responsibility of hospitals,and further clarifies the important function of hospital culture construction in constructing a harmonious physician-patient relationship.
5.Nutrition Status of Premature Neonates in Early Postnatal Stage in Neonatal Intensive Care Unit
Journal of Applied Clinical Pediatrics 2006;0(14):-
Objective To study the nutrition status of premature infants in the early postnatal stage.Methods According to the physical development standard,the premature neonates for treatment in our NICU from Jun.2007 to Jun.2009 were enrolled and divided into normal growth group and extrauterine growth restriction(EUGR) group.The nutrition status of these premature neonates were evaluated respectively.SPSS 13.0 software was used to analyze the data.Results Compared with EUGR group,the durations of regaining birth weight were shorter in normal growth group(t=-13.83,P0.05).Conclusions Premature neonates are prone to encounter extrauterine growth retardation.Extrauterine growth retardation had great impact on premature neonates.Premature neonates should be strengthened with nutrition supplement in order to reduce the incidence of extrauterine growth retardation.
8.Isolation and Screening for Anti-microbial Bacteria from Sponge Dysidea avara
Ying SHEN ; Zhi-Yong LI ;
Microbiology 1992;0(04):-
Sponge Dysidea avara-associated bacteria were isolated by dilution-plate method and the bacterial anti-microbial activities were screened for Escherichia coli,Staphylococcus aureu, Pseudomonas fluorescens, Bacillus subtilis,Aspergillus niger, Candida albicans,Pacecilomyces variotii by agar diffusion method.At the same time, morphology observations, biochemical and physiological identification of active strains were made. In this paper, 149 strains were isolated from sponge Dysidea avara.20 strains, which amount to 13.4% of the total isolated strains, were found to have anti-microbial activity against fungi and gram-positive bacteria and were identified to be the genus Bacillus sp.
9.Alpha 1-antitrypsin Matrix Attachment Region Enhances RNA PolymeraseⅡ-dependent Transcription
Zhi-Yan LI ; Yong ZHANG ;
China Biotechnology 2006;0(04):-
Eukaryotic DNA element called Matrix Attachment Regions (MARs) can function on regulating the structure and activity of chromosome. Traditional quantitation in vitro and indirect functional analysis can not always reflect MAR-involved physiological state. In order to study transcription regulation and make a try in methodism,? 1-antitrypsin MAR (?1-AT MAR) is cloned and incorporated into pEGFP-C1 vector. Non-MAR-containing and MAR-containing plasmids were then transfected into HEK-293 cells with LipofectamineTM 2000 respectively. Positive cell clones were assayed after 20 days of selection by G418. Semiquantitative RT-PCR and fluorescence microscope analysis show that this MAR has a positive effect on modulating nearby gene expression. Further, co-localization with newly CMV promoter and RNA polymeraseⅡ(RNAPⅡ) was detected by chromatin immunoprecipitation (ChIP), The PCR result demonstrates that more RNAPⅡwas recruited to the CMV promoter to initiate transcription in presence of MAR. ChIP can be used to confirm the MAR-mediated transcriptional activation and provide more reliable information than RT-PCR in real time. The technology is also providing a platform for our research in gene expression regulation.
10.Human infection due to Streptococcus suis.
Chinese Journal of Epidemiology 2005;26(9):645-648