OBJECTIVE:To observe the influence of antioxygens(sodium hydrogen sulphite,sodium thiesulfate,disodium edetate)on the stability of rivanol solution.METHODS:The rivanol content was determined by UV-spectrophotometry,and the stability of the rivanol solutions containing different antioxygens was observed by accelerated test.RESULTS&CON?CLUSION:Sodium hydrogen sulphite,sodium thiesulfate and EDTA can not improve the stability of rivanol solution and sodi?um thiesulfate can reduce the stability of rivanol solution.

Objective To investigate the effect of atorvastatin on the curative effect and cardiovascular events in patients with unstable angina pectoris.Methods128 patients with UAP were enrolled in Jinhua Central Hospital from August 2014 to August 2016, and 128 patients with UAP were randomly divided into observation group and control group.All the patients were given low salt and low fat diet.Two groups of patients were anti-platelet aggregation, blood pressure, lipid-lowering and other conventional treatment, observation group on the basis of simultaneous atorvastatin calcium 40mg/d, oral, once every month.The levels of TC, TG and LDL-C, HDL-C and the incidence of cardiovascular events were compared between the two groups before and after treatment.ResultsThere was no case of cardiac death in the observation group and the control group.The incidence of cardiovascular events in the observation group was 9.38%, which was significantly different from that in the control group (P<0.05).The levels of TC, TC and LDL-C in the observation group were significantly higher than those before treatment and control group, respectively.The clinical effect of the observation group was significantly better than that of the control group, the difference was significant (P<0.05).ConclusionAtorvastatin can significantly improve the efficacy of unstable angina treatment, and reduce blood lipid levels, reducing the incidence of cardiovascular events, improve the prognosis.

Suicide is a behavior which forms from the interaction of psychological,social and neurobiological factors.In the past 20 years,increasing evidence has indicated that suicidal behavior bases strong neurobiological factors.This article analyzes and categorizes the neurobiological factors of suicide;introduces existing research on the neurobiology of suicide.

Objective To investigate the significance of anti-SmD1 antibody and other auto-antibod- ies in systemic lupus erythematosus(SLE).Methods Forty-four SLE patients and 136 other rheumatic dis- eases patients were studied.The later group included Sj(?)gren's syndrome,undifferentiated connective tissue disease,ankylosing spondylitis,and rheumatoid arthritis.Immunoblotting was used to measure,the anti-SmD1 antibody,ANuA and anti-SSA60 000 antibody.ANA and anti-dsDNA were detected by indirect immunofluo- rescence,immunodotting was used to measure the anti-Sin antibody.Results The seropositive rate of anti- StuD1 was 47.7% in SLE patients.It was much higher than that of anti-Sm(P

Adolescent ; Humans ; Male ; Microphthalmia-Associated Transcription Factor ; genetics ; Mutation ; Waardenburg Syndrome ; genetics

Treating different diseases with the same method is a unique original thinking in Chinese medicine, which embodies the spirit of treatment based on syndrome differentiation. We briefly reviewed the origin and development of this concept. We also reviewed that thinking of combination of disease and syndrome is its premise and foundation. We put forward the conditionality of diseases in treating different diseases with the same method by cutting-in modern biological basic researches, that is to say, one kind specific diseases or disease of one specific system. We emphasized the importance of diseases conditionality in treating different diseases with the same method, which was of great significance in studies on combination of disease and syndrome, correspondence of prescription and syndrome, and modern biological basic researches of treating different diseases with the same method.
Humans ; Medicine, Chinese Traditional ; Prescriptions ; Research

This study was aimed to analyze medication experiences of Professor Sun Zixue in the treatment of asthenospermia. A total of 286 asthenospermia cases treated by Prof. Sun Zixue were collected. Frequency and index clustering analysis method were used in the processing of patient data. The results showed that the using frequency of 37 types of drugs is more than 10%. And the clustering analysis classified drugs into seven cat-egories , which were the kidney essence tonification , kidney-yang tonification , qi tonification , blood nourish-ment , heat-toxin reducing , heat-dampness reducing , blood-activation and collateral-regulation. It was conclud-ed that based on Prof. Sunˊs syndrome differentiation , the treatment of asthenospermia can be from the combi-nation of kidney tonification , qi tonification and blood nourishment , or the combination of heat-dampness re-ducing and blood-activation and stasis-removing , or the combination of kidney tonification and collateral-regu-lation. The commonly used drugs are 38 types from seven categories .

Objective To detect the expression of CRF and CRF receptors in colonic mucosa of DSS induced colitis in mice model and to study the effect of CRF and CRF receptors on the development.Methods Six to eight weeks healthy female BALB/c mice were divided into control group and DSS group.Setting up DSS colitis model and colitis was evaluated by the disease activity index(DAI) and histological score.The immunofluorescence technique was used to assay the CRF1 and CRF2 receptors expression in colonic mucosa.The expression of CRF and CRF receptors protein were analyzed by western blotting.Results DSS colitis was set up successfully with significant inflammation in colonic mucosa by the disease activity index (DAI) and histological score.Immunofluorescenee staining evidenced that expression of CRF1 receptor in DSS colitis group has no significant deviation compared to control group(P ＞ 0.05),while the expression of CRF2 receptor was elevated in DSS colitis group compared to control group (P ＜ 0.05).CRF2 receptor was localized in epithelial cells and mononuclear cells in the lamina propria.The levels of CRF and CRF2 receptor protein by western blotting were higher in in DSS colitis group compared to control group (P ＜ 0.05).The level of CRF1 receptor protein in DSS colitis group had no significant deviation compared to control group(P ＞ 0.05).Conclusion The higher expression of CRF and CRF2 in colonic mucosa of DSS colitis may participate in the development of colitis.

Objective To investigate the similarities and differences of incomplete Kawasaki disease and typical Kawasaki disease,in order to provide basis for early diagnosis and treatment.Methods The clinical and laboratory data of 60 children with Kawasaki disease were retrospectively analyzed.Results The incidence rate of symptoms in clinical diagnostic criteria was lower in incomplete Kawasaki disease than that in typical Kawasaki disease(x2 =16.46,10.10,11.71,34.43,all P ＜ 0.01).No statistical differences of leukocytes,platelet,erythrocyte sedim-entation rate and C-reactive protein were found in the incomplete Kawasaki disease and typical Kawasaki disease(x2 =0.04,0.12,0.04,0.26,all P ＞ 0.05).The incidence rate of coronary artery lesions had significant difference between incomplete Kawasaki disease and typical Kawasaki disease (x2 =31.43,P ＜ 0.01).Conclusion The early diagnosis of Kawasaki disease could be confirmed by representative clinical characteristics,laboratory examination and ultrasound cardiogram.

Objective:To observe the effect of dissection and reconstruction on palatal muscles morphology in cats. Methods: Nine cats were randomly divided into three groups according to the extension of muscle dissection: small area group(<1/3 group),medium area group(1/3-2/3 group)and large-scale area group(>2/3 group).Control group was the normal palatal muscle in any normal side of the palate.Palatal muscles of all experimental groups were dissected from the posterior border of the hard palate and were reconstructed later. The morphology features and ultrastructure of palatal muscles were observed respectively by HE staining and transmission electron microcopy 1-3 month after operation. Results: There were no obvious differences in morphologic features and ultrastructure of palatal muscles between experiment and normal control groups when the range of palatal muscle dissection was less than 2/3. At early stage (1 month) after operation in large-scale area group, the arrangement of muscles fiber were in structural disorder with inflammatory cell infiltration and muscle fibril formation. The Z line was not distinct, muscles fiber became narrow and myocomma arrangement was not fully dense under transmission electron microcopy. At later stage (2 or 3 month after operation) in large-scale area group, the arrangement of muscles fiber were comparatively regular, neonatal muscles fibers became gradually mature and the amount of inflammatory cell had obviously decreased. Ultrastructure study showed that myocomma arrangement was more orderliness, and Z line became more distinct. Conclusion: It suggests that the extensive dissection of palatal muscles carried no fibrosis, and injury musculature could be repaired and regenerated.