AIM: To investigate the pbarmacokinetics of lyophilization of toad venom(Venenum Bufouis)-loaded solid lipid nanoparticles(Vs-SLN). METHODS: Cinobufagin and resibufogenin plasma concentration in rat was determined by RP-HPLC. RESULTS: Statistic test showed that there was significant difference between lyophilization of Vs-SLN and Vs-injection for C_(max)、 AUC_(extra)、 MRT. CONCLUSION: As the circulating time of the drug in blood was markedly prolonged,Vs-SLN can be developed to a novel preparation for controlled release of lipophilic drugs.

USB is a very popular interface in recent computer systems.USB communication enjoys great popularization with many advantages such as high velocity,high reliability and joint flexibility,which traditional RS232 communication,serial and parallel communication have not.This paper presents CH375 bus interface chips,the USB communication between PC and embedded medical equipment,and the relative procedure code.

Objective To develop the USB device driver for embedded medical equipment based on Linux.Methods A Miniature Parameter Monitor based on embedded linux was designed.It used ARM9 microprocessor s3c2410 as main CPU of hardware control center,embedded linux OS as software development platform and had one USB interface.USB device driver's system-structure and programming methods were studied.Drive program applying to the specific platform is developed.Results This programming is greatly simplified compared to the old one.By testing,the system could mount USB flash disk automatically,exchange data accurately.The transmission speed was fast,reliable and stable.Conclusion The USB device driver can improve the speed and quality of the data exchange between the equipment and host computer as well as the equipment and function modules.Great storage capacity is realized and its hot plug is so convenience in using.

Objective To evaluate the curative effects of Hybrid external fixator in the treatment of severely comminuted and open fractures of the distal or proximal tibia. Methods From March 2004 to December 2008,we treated 27 patients with severely comminuted and open fractures of the distal or proximal tibia with the Hybrid frame purchased from Orthofix Co.in combination with limited internal fixation if necessary.The internal fixation was done with screws in 6 cases,with absorbable interference serews in 4 and with wire in 3.There were 16 males and 11 females,with an average age of 56.2(13 to 80)years.Accordins to Gustilo-Anderson classification,there were 10 cages of typeⅡ,12 cases of type Ⅲ A and 5 cases ofⅢB.The injuries were mostly caused by traffic accident and fall.Postoperative ankle and/or knee funetions were evaluated by Johner-Wrubs system.Results The patients were followed up for 7 to 58 months(average,27 months).Averagely the patients obtained bone union at 6.7 months and fixator removal at 6 months after operation.The postoperative JohnerWruhs score was excellent in 17 cases.good in 8 and fair in 2.The total exceHent to good rate was 92.6%,without wound infection or complications of nerve and vessel injury.There were only 5 cages of local superficial pin tract infection which responded to oral antibiotics and disinfectants. Conclusion In treatment of severely comminuted and open fractures of the distal or proximal tibia,Hybrid frame fixation may lead to limited invasion,reliable fixation,low rate of complications,and early recovery of joint function.

Nerve growth factor (NGF) and its high affinity receptor tyrosine kinase (TrkA)are indis-pensable for the development of nervous system. Latest researches reveal that over-expression of NGF and TrkA is related to better outcome in neuroblastoma and medulloblastoma. While in glioma, the over-expression and nuclear translocation of NGF and TrkA are indicators of malignant degree. Study of the expression and sub-cel-lular cocalization of NGF and TrkA can provide new way for the diagnosis and therapy of nervous system tumors.

AIM: To explore the effect of radial axial incision on corneal astigmatism after phacoemulsification.METHODS: Totally 60 cases (62 eyes) of cataract patients were selected from our hospital, divided into Group A and Group B randomly.Two groups were both required to have a corneal incision, while Group A took it in the maximum corneal refractive radial axial and the Group B took it in the traditional temporal side (right eye) or nasal side (left eye).At the same time two groups received phacoemulsification and foldable intralocular lens (IOL) implantation.We measured their date before surgery, after surgery in 1d, 1wk and 1mo respectively with CT200 corneal topography measurement.The date was compared in two groups of corneal astigmatism, surgically induced astigmatism and visual acuity.According to the corneal astigmatism and axial, surgically induced astigmatism was calculated.RESULTS: Group A and Group B were compared in age, gender, lens nucleus hardness, visual acuity, corneal astigmatism before the surgery, which has no statistically significant differences (P>0.05).Postoperative visual acuity of both groups was higher than preoperative (P<0.05), but the difference was not statistically significant in 1d, 1wk and 1mo after surgery in two groups (P>0.05).Corneal astigmatism was not statistically significant in two groups at 1d after surgery (P>0.05).The corneal astigmatism was significantly less in Group A than that in Group B in 1wk and 1mo after surgery, and the difference was statistically significant (P<0.05).After the surgery for 1wk and 1mo, the surgically induced astigmatism of Group B was significantly higher than that of the Group A, with the difference was statistically significant (P<0.05).CONCLUSION: Making clear corneal incision along the maximum curvature of the cornea in cataract surgery can make the corneal astigmatism and the degree of astigmatism less after surgery.

Humans ; Laser Therapy ; Male ; Prostatic Hyperplasia ; surgery

OBJECTIVE:To explore a feasible working model suitable for clinical pharmacists engaged in cardiovascular diseases.METHODS:We analyzed our experience in the personal clinical practice of pharmaceutical care as well as the clinical features of cardiovascular diseases.RESULTS & CONCLUSIONS:It is of great importance for pharmacists to provide pharmaceutical care for nurses and interns and help make medication plan for complicated cases via "4R" clinical rounds in that the clinical pharmacists engaged in cardiovascular diseases can adapt to clinical work and become a member of medical team early.

OBJECTIVE: To establish a feasible method for the clinical pharmacists of cardiovascular diseases during training stage. METHODS: Drawn from the author's experiences, the clinical features of cardiovascular diseases were analyzed and summed up. RESULTS & CONCLUSIONS: A good method is useful for the clinical cardiovascular pharmacist to carry out the medical work and become a member of clinical therapeutic team as sooner as possible.

Animals ; Birds ; China ; Hong Kong ; Humans ; Influenza A virus ; classification ; pathogenicity ; Influenza in Birds ; complications ; prevention & control ; Influenza, Human ; etiology ; prevention & control ; Prognosis ; World Health Organization