Consumer Product Safety ; Food ; Food Safety ; Risk Assessment ; Safety Management ; methods

Promyelocytic leukemia (PML) protein can regulate many cellular processes, Here we summarize the role of PML protein in cell and mechanisms according to researches in recent years.

Objective To assess the value of procalcitonin( PCT) in anti-infective therapy by observing PCT concentration change in therapy. Methods Sixty-eight patients with bacterial infection meet the diagnostic criteria were divided into effective group and invalid group,the PCT level on day 1,day 3,day 5 and day 7 were observed respectively. Results PCT concentrations of two groups showed no sig-nificant difference on day 1. The PCT level of effective group gradually declined and PCT level of invalid group gradually rised with significant difference on day 3,day 5 and day 7(P<0. 05). Conclusion PCT level that is positively correlated with inflammation of infectied patients, which can be used as an effective indicator to optimize antibiotic therapy.

Humans ; Olfaction Disorders ; genetics ; Smell ; genetics

Genetic Predisposition to Disease ; Humans ; Olfaction Disorders ; congenital ; genetics

This study was aimed to find the optimal conditions for seed propagation of Fritillaria cirrhosa in the plateau region in order to summarize the best sowing time and method of artificial propagation. Seeds were stored in appropriate environment. After the seeds matured, the seedbed of F. cirrhosa was treated with cattle dung humus and small shed. The results showed that early March is the best sowing time and cattle dung humus with a thickness about 1 cm is the best coving for propagation of F. cirrhosa; the growing period of film propagation (FP) is about 160 days each year compared with that of control about 50-60 days, respectively. It was concluded that the propagating seeds in plastic greenhouses by using cattle dung humus as planting substrates, using sunshade nets for shading and keeping humidity by spraying can effectively prolong the growing period, improve the retention rate of annual bulbs and the production of F. cirrhosa.

Glucocorticoids ; therapeutic use ; Humans ; Olfaction Disorders ; drug therapy ; Treatment Outcome

Objective To investigate the distribution and effect of class Ⅰ integron in 40 strains of clinical multi-resistant Enterobacter cloacae. Methods Kirby-Bauer method was used to analyze the drug resistance of 40 strains of multi-resistant Enterobacter cloacae and the drug resistance gene was analyzed by polymerase chain reaction (PCR). Results 28 strains (70.0%) of 40 clinical isolates were observed to contain class Ⅰ integron. Drug resistance test showed their resistance rate to 10 kind of an-tibaeterials as follow: 7.5% to imipenem, 5.0% to meropenem, 75.0% to piperacillin-tazobactam,55.0% to amikacin, 12.5% to cefepime, 52.5% to ceftazidime, 55.0% to cefotaxime, 90.0% to ceftriaxone;81.8% to ticarcillin-clavutanic acid, and 85.0% to ciprofloxacin. Conclusion This study shows that the resistance situation of Enterobacter cloacae isolates is very serious, and class Ⅰ integron may play an important role in the muhidrug resistant mechanism.

Objectives:The present study in vestigated the presence and significance of serum antibody against human myocardial mitochondria in patients with virus myocarditis (VMC) and dilated cardiomyopathy (DCM). 　　Methods:The human myocardial mitochondtia were used as antigen to detect serum autoantibody by immuno-dot blot in 29 VMC patients,24 DCM patients,33 patients with other cardiac (OCD) and 20 healthy blood donor (HBD).The antigen molecular weight was detected by Western blot. 　　Results:①Positive autoantibody against human myocardial mitochordria was found in 41.4% in VMC and 41.7% in DCM patients,which were much higher than 6.1% in OCD or 0% in HBD patients.②Cardiac troponin T was elevated in 43.8% of autoantibody-positive VMC and DCM patients,which was much higher than 12.0% in autoantibody-negative VMC and DCM patients (p＜0.05).③The antigen molecular weight of human myocardial mitochondria was 30KD. 　　Conclusions:①The presence of autoantibody against supports that concept that is responsible for the development of VMC and DCM.Autoantibody is one of the factors that give rise to cardiac injury.The antibody detection may serve as a diagnostic index for VMC and DCM.②The specific antigen is probably human myocardial adenine nucleotide translocator.

Adult ; Aged ; China ; epidemiology ; Female ; Gold ; Humans ; Male ; Middle Aged ; Mining ; Silicosis ; mortality ; Young Adult