1.Seroepidemiologic survey of residents and urban rats against the etiologic agents of hemorrhagic fever with renal syndrome in Singapore.
Ho Wang LEE ; Sang Youl LYU ; Lack Ju BAEK ; Yong Kyu CHU ; Wong Tae WAI ; Chan Yew CHEONG
Journal of the Korean Society of Virology 1991;21(1):77-85
No abstract available.
Animals
;
Hemorrhagic Fever with Renal Syndrome*
;
Rats*
;
Singapore*
2.Risk factors of positive surgical margin and biochemical recurrence of patients treated with radical prostatectomy: a single-center 10-year report.
Kin LI ; Hong LI ; Yong YANG ; Lap-Hong IAN ; Wai-Hong PUN ; Son-Fat HO
Chinese Medical Journal 2011;124(7):1001-1005
BACKGROUNDMany studies have shown that positive surgical margin and biochemical recurrence could impact the life of patients with prostate cancer treated with radical prostatectomy. With more and more patients with prostate cancer appeared in recent 20 years in China, it is necessary to investigate the risk of positive surgical margin and biochemical recurrence, and their possible impact on the prognosis of patients treated with radical prostatectomy. In this study, we analyzed the characteristics of patients with prostate cancer who had undergone radical prostatectomy in Macau area and tried to find any risk factor of positive surgical margin and biochemical recurrence and their relationship with the prognosis of these patients.
METHODSFrom 2000 to 2009, 149 patients with prostate cancer received radical prostatectomy and were followed up. Among these patients, 111 received retropubic radical prostatectomies, 38 received laparoscopic radical prostatectomies. All patients were followed-up on in the 3rd month, 6th month and from that point on every 6 months after operation. At each follow-up a detailed record of any complaint, serum prostate-specific antigen (PSA), full biochemical test and uroflowmetry was acquired.
RESULTSThe average age was (69.0 ± 6.1) years, preoperative average serum PSA was (10.1 ± 12.1) ng/ml and average Gleason score was 6.4 ± 1.3. The incidence of total complications was about 47.7%, the incidence of the most common complication, bladder outlet obstruction, was about 26.8%, and that of the second most common complication, urinary stress incontinence, was about 16.1% (mild 9.4% and severe 6.7%). The incidence of positive surgical margin was about 38.3%. The preoperative serum PSA ((13.4 ± 17.6) ng/ml), average Gleason score (7.1 ± 1.3) and pathological T stage score (7.0 ± 1.4) were higher in patients with positive surgical margins than those with negative margins ((8.0 ± 5.8) ng/ml, 6.0 ± 1.2 and 5.4 ± 1.4, respectively) (P = 0.004, P = 0.001 and P = 0.001, respectively). A univariate analysis showed that positive surgical margin had a positive statistical association with serum PSA (P = 0.007), Gleason score (P < 0.001), pathological T stage score (P < 0.001) and biochemical recurrence (BCR) (P = 0.035). The most common location of a positive surgical margin was in the apex of the prostate, which was about 63% (36/57). Sixty-four percent (23/36) of patients with positive surgical margin in apex were also involved in prostate lobe; other locations were prostate lobe (23%, 13/57), seminal vesicle (9%, 5/57). The multivariate analysis showed that positive surgical margin had a positive statistical association with Gleason score (P = 0.03) and pathological T stage score (P = 0.02). Neither univariate analysis or multivariate analysis showed any statistical relationship between BCR and any other risk factors covered in this study.
CONCLUSIONSPositive surgical margin is associated with pre-operative PSA, Gleason score, pathological T stage and biochemical recurrence. Earlier diagnosis and improved techniques of dissection of prostate apex could decrease the incidence of positive surgical margins.
Aged ; Humans ; Male ; Middle Aged ; Prostate-Specific Antigen ; blood ; Prostatectomy ; methods ; Prostatic Neoplasms ; blood ; pathology ; surgery ; Risk Factors
3.Missed opportunities for earlier HIV-testing in patients with HIV infection referred to a tertiary hospital, a cross-sectional study
Kwee Choy Koh ; Mahfuja Islam ; Weng Kien Chan ; Wei Yi Lee ; Yong Wai Ho ; Syed Abdul Hannan Alsagoff ; Rini Azura Yusof
The Medical Journal of Malaysia 2017;72(4):209-214
Introduction: In Malaysia, the prevalence of missed
opportunities for HIV-testing is unknown. Missed
opportunities have been linked to late diagnosis of HIV and
poorer outcome for patients. We describe missed
opportunities for earlier HIV-testing in newly-HIV-diagnosed
patients.
Methods: Cross sectional study. Adult patients diagnosed
with HIV infection and had at least one medical encounter in
a primary healthcare setting during three years prior to
diagnosis were included. We collected data on sociodemographic
characteristics, patient characteristics at
diagnosis, HIV-related conditions and whether they were
subjected to risk assessment and offered HIV testing during
the three years prior to HIV diagnosis.
Results: 65 newly HIV-diagnosed patients (male: 92.3%;
Malays: 52.4%; single: 66.7%; heterosexual: 41%;
homosexual 24.6%; CD4 <350 at diagnosis: 63%). 93.8%
were unaware of their HIV status at diagnosis. Up to 56.9%
had presented with HIV-related conditions at a primary
healthcare facility during the three years prior to diagnosis.
Slightly more than half were had risk assessment done and
only 33.8% were offered HIV-testing.
Conclusions: Missed opportunities for HIV-testing was
unacceptably high with insufficient risk assessment and
offering of HIV-testing. Risk assessment must be promoted
and primary care physicians must be trained to recognize
HIV-related conditions that will prompt them to offer HIVtesting.
4.Acquired double pylorus.
Enming YONG ; Enhui YONG ; Junice Shi Hui WONG ; Thomas Wai Thong HO
Singapore medical journal 2018;59(6):335-336
5.Interview Functional Independence Measure score: self-reporting as a simpler alternative to multidisciplinary functional assessment.
Shaji Jose VADASSERY ; Keng He KONG ; Wai Mun Lorraine HO ; Aruni SENEVIRATNA
Singapore medical journal 2019;60(4):199-201
INTRODUCTION:
The Functional Independence Measure (FIM) is a validated, objective assessment of functional status. It is widely used in rehabilitation centres but may not be practical for all patients due to time and/or personnel constraints. Studies show positive and negative agreement on self-reported FIM scores for patients with spinal cord injuries and amputees. We tested the validity of the self-reported FIM motor score among stroke patients.
METHODS:
We conducted a prospective double-blind comparative study of patient self-reporting against multidisciplinary assessment, using the standard FIM algorithm. All eligible stroke patients (n = 47) admitted to our rehabilitation centre were included. 33 patients were included in the final analysis.
RESULTS:
There was substantial agreement on overall FIM motor score between patient self-reporting and multidisciplinary assessment (intraclass correlation coefficient [ICC] 0.651, 95% confidence interval 0.404-0.811). The scores of individual motor items also showed fair-to-good agreement (ICC range 0.431-0.618), except for eating, grooming, bathing and dressing of the lower body (ICC < 0.400).
CONCLUSION
There was no FIM assessment for 14 (29.8%) patients, highlighting the need for alternative assessment tools. Discrepancies in some scores could be due to patients' ignorance of their own limitations or feelings of embarrassment about reporting. Our results may not be valid for patient populations with cognitive or communication deficits. However, a modest agreement between patient self-reporting and multidisciplinary assessment of FIM motor score was demonstrated. Although patients tend to overrate their performance, self-reported FIM motor scores could be an alternative in situations where multidisciplinary FIM assessment is difficult.
6.Guidance for the clinical management of infants born to mothers with suspected/confirmed COVID-19 in Singapore.
Kee Thai YEO ; Agnihotri BISWAS ; Selina Kah YING HO ; Juin Yee KONG ; Srabani BHARADWAJ ; Amutha CHINNADURAI ; Wai Yan YIP ; Nurli Fadhillah AB LATIFF ; Bin Huey QUEK ; Cheo Lian YEO ; Yvonne Peng MEI NG ; Kenny Teong TAI EE ; Mei Chien CHUA ; Woei Bing POON ; Zubair AMIN
Singapore medical journal 2022;63(9):489-496
In this paper, we provide guidance to clinicians who care for infants born to mothers with suspected/confirmed COVID-19 during this current pandemic. We reviewed available literature and international guidelines based on the following themes: delivery room management; infection control and prevention strategies; neonatal severe acute respiratory syndrome coronavirus 2 testing; breastfeeding and breastmilk feeding; rooming-in of mother-infant; respiratory support precautions; visiting procedures; de-isolation and discharge of infant; outpatient clinic attendance; transport of infant; and training of healthcare staff. This guidance for clinical care was proposed and contextualised for the local setting via consensus by members of this workgroup and was based on evidence available as of 31 July 2020, and may change as new evidence emerges.
Infant, Newborn
;
Pregnancy
;
Female
;
Humans
;
Mothers
;
COVID-19/epidemiology*
;
Singapore/epidemiology*
;
COVID-19 Testing
;
Pandemics/prevention & control*
;
Infectious Disease Transmission, Vertical/prevention & control*
;
Pregnancy Complications, Infectious/prevention & control*