Marine Biology ; Peptides

The glucocorticoid receptor (GR) is a ligand-dependent transcription factor belonging to the nuclear hormone receptor superfamily. Due to its almost ubiquitous expression, GR plays an important role in many physiological and pathological processes. These include regulation of homeostasis, adaptation to stress, and modulation of central nervous system. In addition, GR is a major modulator of the immune system due to its proficient anti-inflammatory and immunosuppressive activity; and its function is important for proper regulation of many physiological processes. The exploration on the regulation of traditional Chinese medicine on GR has established a modern physiological and pathological foundation for research of traditional Chinese medicine.

Objective To compare the clinical effects of peritoneal cavity after laparoscopic renal pelvis and ureter lithotomy and traditional open renal pelvis incision nephrolithotomy.Methods 150 cases with renal pelvis and ureteral calculi were randomly divided into control group and observation group with 75 cases in each group,the control group was given traditional open pyelolithotomy for treatment while the observation group was given peritoneal cavity after laparoscopic renal pelvis and ureter lithotomy for treatment,clinical efficacy of the two groups were compared.Results The clinical effective rate of the observation group after treatment was 100％,which that of the control group was 92％,there was significant differences between the two groups (x2 =10.31,P ＜ 0.05).The operation time in the observation group was (90 ± 12) min,amount of bleeding during operation was (25 ± 7) mL,hospital stays was (10 ± 3) d,which were better than those of the control group,there were significant differences between the two groups (t =7.24,8.31,7.61,all P ＜ 0.05).Conclusion Retroperitoneal laparoscopic pyelolithotomy and ureterolithotomy is a minimally invasive operation,which has the advantages of definite curative effect,less trauma,less bleeding,rapid recovery,superior than the traditional open pyelolithotomy,so it is worthy of clinical application.

Objective To investigate the effect of atorvastatin and fluvastatin in unstable angina patients after intervention on matrix metalloproteinase-9 (MMP-9) and interleukin-18 (IL-18).Methods One hundred and four patients with unstable angina were divided into atorvastatin group and fluvastatin grourp with 52 cases each by random digits table.Atorvastatin group was given atorvastatin 10 mg/d,and fluvastatin group was given fluvastatin 40 mg/d for 6 weeks on the basis of conventional treatment.The change of blood fat,MMP-9 and IL-18 was observed in two groups.Results There was no significant difference in MMP-9 and IL-18 on admission,1 d before operation and 1 d or 6 weeks after operation between atorvastatin group and fluvastatin group (P ＞ 0.05).The level of MMP-9,IL-18 1 d after operation in atorvastatin group and fluvastatin group was higher than that on admission,1 d before operation [(328.47 +49.15) μg/L vs.(237.10 + 57.32),(235.97 + 56.24) μ g/L,(218.75 + 38.00) ng/L vs.(120.42 + 25.50),(115.22 + 28.93)ng/L and (330.42 ± 50.04) μ g/L vs.(235.98 ± 60.36),(236.29 ± 53.02) μ g/L,(220.16 ± 37.12) ng/L vs.(119.43 ± 24.85),(117.14 ± 26.80) ng/L] (P ＜ 0.05).The level of MMP-9,IL-18 6 weeks after operation was decreased in atorvastatin group and fluvastatin group [(152.28 ± 43.20) μ g/L,(101.36 ± 23.67) ng/L and (150.30 ± 44.18) μ g/L,(100.45 ± 24.58) ng/L],which had significant difference compared with that on admission,1 d before and after operation(P ＜ 0.05).There was no significant difference in triacylglycerol (TG),total cholesterol (TC),high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) on admission,1 d before and after operation between atorvastatin group and fluvastatin group (P ＞ 0.05).There was significant difference in TG,TC,HDL-C,LDL-C 6 weeks after operation between atorvastatin group and fluvastatin group [(2.05 ± 1.00),(5.15 ±0.61),(1.84 ±0.50),(3.13 ±0.88) mmol/L and (1.87 ± 1.05),(5.52 ± 0.84),(2.82 ± 0.57),(2.61 ± 0.79) mmol/L] (P ＜ 0.05).There was no significant difference in TG,TC,HDL-C,LDL-C 1 d after operation compared with that on admission,1 d before operation (P ＞ 0.05).There was significant difference in TG,TC,HDL-C,LDL-C 6 weeks after operation compared with that on admission,1 d before and after operation in atorvastatin group and fluvastatin group (P ＜0.05).Conclusions In unstable angina patients after intervention,MMP-9,IL-18 can significantly increase.Atorvastatin or fluvastatin therapy can obviously reduce the MMP-9,IL-18 and lipid level,but fluvastatin shows better effect.

Cross-Cultural Comparison ; Medicine, Chinese Traditional ; Translations

In order to study the effects on air Pollution,Passive smoking and fuel type to 174 cases children's salivary lysozyme and pulmonary funvtions,we have analysed thesurveyed results with CANONICAL CORRELATION ANALYSIS.The results showed negative Correlation between two group variables.The weighted variables included X2(0.7460),X1(0.7221),Y1(-0.9665),Y10(-0.5456)and Y9(-0.5186).All the opposite signs indicated that declines of children's salivary lysozyme level and sma-11-airmays function were caused directly by air Pollutant levels and total numbers of passive smoking.

Objective To evaluate the efficacy and safety of mini-incision transthoracic occlusion for patent ductus arteriosus(PDA)in adults.Methods From November 2005 to May 2007,10 adult patients(occlusion group)received mini-incision transthoracic occlusion of PDA under the guidance of transesophageal ultrasonography in our hospital.A 3-to 5-cm incision was made at the second intercostal space adjacent to the left sternum to expose the pulmonary aorta.Afterwards,a catheter was introduced into the pulnonary artery,and then delivered into the aorta via the PDA under the guidance of ultrosonograohpy.An occluder of 4 to 6 mm larger than the PDA in diameter was then released to engage on the defect.Twenty patients who recieved on-pump surgery were set as a control group.Results Compared with the control,patients in the occlusion group had a smaller incision [(3.6?1.6)cm vs(25.3?5.4)cm,t'=-16.575,P

Objective: To determine the cerebral activation patterns associated with processing of English semantic judgment task by fMRI in native Chinese bilinguists.Methods: 12 native Chinese bilinguists were divided into two groups with 6 in each group,English-specialized and non-English-specialized group,and performed English words semantic judgment task,whose fMRI images were collected.Results: All subjects demonstrated significant activation of associated cerebral regions.Besides classical regions involved in language processing,such as Wernicke and Broca areas,there were other activated cerebral regions,including cerebellum,limbic system and basal ganglial nucleus,etc.The analysis of ROI implied that subjects in the specialized group were more dependent on the right hemisphere.Conclusions: Left hemisphere dominates in language cognition,although which is also related to the right hemisphere to various degrees.Two hemispheres work by ways of both dissociation and coordination.It is possible that working strategy of the right hemisphere is related to proficiency of the second language.A variety of distinctions are shared by each subject for language cognitive patterns.

The early cardiac biological pacemaker studies were mostly around HCN channel, and how to build a biological pacemaker through the enhanced If current. In recent years, however, people found that the genes of Tbx3 could play an important role in the development of cardiac conduction system, especially in processes of the maturity of the sinoatrial node and maintenance of its function. And the Tbx3 can further optimize the biological pacemaker. Therefore, it could be a new therapeutic focus in biological pacemaker and treatment of cardiac conduction system disease. This paper summarizes some of the latest research progress of the Tbx3 in biological pacemaker in recent years. We hope that this review could provide theoretical basis for the clinical applications of Tbx3.
Arrhythmias, Cardiac ; genetics ; Biological Clocks ; Brugada Syndrome ; Cardiac Conduction System Disease ; Heart ; physiopathology ; Heart Conduction System ; abnormalities ; Humans ; Sinoatrial Node ; T-Box Domain Proteins ; genetics

Objective To discuss the application value of diffusion weighted imaging(DWI)in the diagnosis and treatment of synovial sarcoma.Methods 48 patients with synovial sarcoma were selected.All patients were given conventional magnetic resonance imaging (MRI)and DWI detection examination,DWI diffusion sensitive factor examination was 500 s/was(b).All the patients'imaging results and disease detection were analyzed.ROC curve was used to analyze the value of DWI,MRI examination in the diagnosis of synovial sarcoma.Results DWI examination detection of synovial sarcoma was much higher than that of MRI,the difference was statistically significant(χ2 =5.62, P <0.05).ROC curve analysis showed that MRI examination in the diagnosis of synovial sarcoma specificity was 72.58%,sensitivity was 79.12%,the accuracy was 86.82%,DWI examination in the diagnosis of specificity was 76.81%,sensitivity was 85.79%,the accuracy was 95.18%.The sensitivity,specificity and accuracy of DWI were significantly higher than conventional MRI,the differences were significant(χ2 =5.72,5.68,5.12,all P <0.05). Conclusion DWI can effectively improve the detection rate of synovial sarcoma,and has higher diagnostic sensitivity, specificity and accuracy,it's conducive to the physician for treatment in a timely manner,and worthy of further clinical promotion.