1.A case of acute methotrexate toxicity.
Annals of the Academy of Medicine, Singapore 2011;40(2):97-99
Acute Disease
;
Antimetabolites, Antineoplastic
;
adverse effects
;
toxicity
;
Drug-Related Side Effects and Adverse Reactions
;
Female
;
Folic Acid Antagonists
;
therapeutic use
;
Humans
;
Methotrexate
;
adverse effects
;
toxicity
;
Middle Aged
;
Nausea
;
chemically induced
;
Risk Factors
;
Skin Diseases
;
chemically induced
;
Vomiting
;
chemically induced
3.Cutaneous Adverse Drug Reactions in a General Hospital in Singapore: A One-Year Retrospective Analysis
Rachael YL Teo ; Yong Kwang Tay ; Kwong Ming Fock
Malaysian Journal of Dermatology 2007;19(-):79-82
Background Rashes are the most common adverse reaction to drugs. Our aim is to describe (i) the prevalence of cutaneous adverse drug reactions in hospitalised patients over a 1-year period in our hospital;
(ii) the variety of cutaneous drug reactions; (iii) the characteristics of patients with cutaneous drug reactions and (iv)the drugs implicated.
Methods A retrospective analysis of all adverse drug reactions from the pharmacists’ database from January to December 2003 was conducted. Patients’ records were reviewed to extract demographic data, drug implicated, route of administration, drug allergy history, type
of cutaneous reaction, severity and presence of underlying chronic disease.
Results Sixty-five patients met our inclusion criteria, giving an estimated prevalence of 1.8/1000 among hospitalised patients. The cases were mostly from the general medicine department (64.6%), with
a slight male predominance (males, 53.8%; females 46.2%). Cutaneous adverse drug reactions were more common in the Malay population (32.3%). The mean age was 41.6 years (range, 13 to 85 years). The main drugs implicated were antibiotics (49.2%), mainly penicillins and
cephalosporins, and non-steroidal anti-inflammatory agents (16.9%). Urticarial (46.1%) and generalised maculopapular eruptions (40.0%) were the most common patterns encountered. Others included Stevens-Johnson syndrome/toxic epidermal necrolysis (7.7%), drug
reaction with eosinophilia and systemic symptoms (1.5%) and
erythroderma (1.5%). 29.2% of cases were considered to be severe. There were no deaths. 44.6% had an associated chronic disease and 24.6% had a previous documented drug allergy.
Conclusion Antibiotics and NSAIDs were the major drugs involved. The commonest cutaneous manifestations were urticarial and maculopapular eruptions. A high proportion of reactions were considered severe and almost one-quarter had a previous drug allergy.
5.Inflammatory tinea capitis: non-healing plaque on the occiput of a 4-year-old child.
Chia Chun ANG ; Yong Kwang TAY
Annals of the Academy of Medicine, Singapore 2010;39(5):412-414
INTRODUCTIONInflammatory tinea capitis is an uncommon condition in Singapore. In this case report we present a patient whom we managed for this condition.
CLINICAL PICTUREA 4-year-old girl presented to us with multiple pustules over the occipital scalp for 6 weeks, associated with painful cervical lymphadenopathy. Her condition did not respond to topical and oral antibiotics.
TREATMENTThe patient was diagnosed with kerion (inflammatory tinea capitis) and fungal culture of plucked hairs from the kerion grew Microsporum species of dermatophyte. She was treated with a course of oral griseofulvin and topical selenium sulfide shampoo. She was advised to bring her pet cats to the veterinarian for screening, as well as not to share combs with her other siblings.
OUTCOMEHer condition improved with the antifungal therapy, and there was no residual alopecia.
CONCLUSIONPhysicians should consider tinea capitis when they encounter a patient with scalp folliculitis or scarring alopecia in the appropriate clinical context.
Administration, Oral ; Administration, Topical ; Antifungal Agents ; administration & dosage ; Child, Preschool ; Female ; Griseofulvin ; administration & dosage ; Humans ; Microsporum ; isolation & purification ; Selenium Compounds ; administration & dosage ; Tinea Capitis ; drug therapy ; microbiology
6.A 40-Year-Old Man with Rashes and Palpitations.
Shan Xian LEE ; Yong Kwang TAY
Annals of the Academy of Medicine, Singapore 2016;45(6):264-266
Adult
;
Cardiomyopathies
;
diagnosis
;
etiology
;
Electrocardiography
;
Heart Block
;
diagnosis
;
etiology
;
Humans
;
Male
;
Sarcoidosis
;
complications
;
diagnosis
;
pathology
;
Skin Diseases
;
diagnosis
;
etiology
;
pathology
8.Localised dermatitic nodules but no itch.
Siew Kiang TAN ; Yong Kwang TAY
Annals of the Academy of Medicine, Singapore 2015;44(2):71-72
Humans
;
Male
;
Middle Aged
;
Prurigo
;
complications
;
diagnosis
;
Pruritus
;
Sciatica
Result Analysis
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