OBJECTIVE:To study the preparation and quality control methods of ribavirin and ephedrine nasal spray and observe its clinical therapeutic efficacy.METHODS:To determine the content of ribavirin and that of ephedrine hydrochloride by ultraviolet spectrophotometry and polarimetry respectively and observe the clinical therapeutic efficacy in 40 patients.RES_ULTS:The average recoveries of ribavirin and ephedrine hydrochloride were 100.05%(RSD=0.50%) and 100.10%(RSD=0.29%) respectively.Its effective rate in treating virus infections of upper respiratory tract was 97%.CONCLUSION:The preparation of ribavirin and ephedrine nasal sprays is reasonable in technology,stable in quality,feasible in quality control and reliable in therapeutic efficacy.It is worth popularizing the application of this preparation.

This article analysis the present situation of less than 35 years of Sun Yat-sen university youth scientific and technological personnel,they declare、undertake to support basic research based science fundation related cases,discusses the science foundation for their assistance and training problems,put forward youth scientific talents to suit the science funds development requirements to promote their development proposals

Endometrial Neoplasms ; pathology ; surgery ; Female ; Humans ; Lymph Node Excision ; methods ; Lymph Nodes ; pathology ; Neoplasm Staging ; Ovarian Neoplasms ; pathology ; surgery ; Retroperitoneal Space

Anoctamin-1 ; Antineoplastic Agents ; administration & dosage ; Benzamides ; Biomarkers, Tumor ; metabolism ; Chloride Channels ; Drug Delivery Systems ; methods ; Gastrointestinal Neoplasms ; genetics ; metabolism ; pathology ; therapy ; Gastrointestinal Stromal Tumors ; genetics ; metabolism ; pathology ; therapy ; Humans ; Imatinib Mesylate ; Indoles ; administration & dosage ; Membrane Proteins ; metabolism ; Neoplasm Proteins ; metabolism ; Piperazines ; administration & dosage ; Proto-Oncogene Proteins c-kit ; metabolism ; Pyrimidines ; administration & dosage ; Pyrroles ; administration & dosage ; Receptor, Platelet-Derived Growth Factor alpha ; genetics ; metabolism ; Vascular Endothelial Growth Factor A ; metabolism

The essential factors of bone tissue engineering include seed cell,growth factor and scaffold material.The biological structure,biological function and preparation method of scaffold material,which is the key component in bone tissue engineering,have attracted our attention.An ideal scaffold material needs to have adequate mechanical strength,appropriate degradation speed,good biocompatibility,satisfactory availability,low price,et al.Common scaffold materials in bone tissue engineering mainly consist of inorganic matter,organic matter and natural derivatives.Silk fibroin which is extracted from silkworm protein fiber contains 18 kinds of amino acids.The glycine,alanine,serine are the main types in silk fibroin and its structure consisted of hydrogen bonding,hydrophobic bonding and crystalline region.Those special structures make it has good flexibility and tensile strength.Silk fibroin has other advantages incluing air permeability,moisture permeability and biodegradation.Besides silk fibroin with curing crystallization of diversification that easy to maintain biological affinity and form a special porous structure.Silk fibroin has good film and gel forming ability.Silk fibroin can bond with some other materials to further improve its physical and chemical properties.Silk fibroin can be formed into porous shape,membranous,gel and composite materials scaffold.The materials scaffold which based on silk fibroin has excellent mechanical performance,adjustable degradation speed,high biocompatibility and good osteogenesis performance,besides capability of loading cells,bioactive factors and drugs.In addition,silk fibroin which can be made into gel scaffold,porous scaffold,electrospinning fiber,and compound scaffold et al has three-dimensional porous and biological function for bone tissue engineering as a new choice and application prospect.

Probiotics modulate the biological functions (and even cell apoptosis) of intestinal epithelial cells,intestinal macrophages,intestinal dendritic cells,and T cells via cell signaling pathways including nuclear factor-kappa B (NF-κB) and mitogen-activated protein kinase (MAPK) pathways.Peroxisome proliferator-activated receptor γ (PPARγ) and heat shock protein (hsp) are targets for probiotics or their products.

T helper 17 cells (Th17) are a novel subset of CD4+ T cells that undergo differentiation from naive CD4 T cells through the activation of a key nuclear transcription factor,retinoic-acid-receptor-related orphan receptor γt (RORγt),and in the presence of multiple cytokines,such as transforming growth factorβ1 (TGF-β1),interleukin6 (IL-6),as well as IL-23.Th17 cells induce their biological effect by secreting IL-17A and other cytokines.Research has demonstrated that Th17 cells have an intimate relationship with acute/chronic transplant reactions and that Th17 cell lineages have the possibility to become the new target for treating transplant rejections.Identification of Th17 cells also provides an additional strategy for inducing immune tolerance.

Over the past twenty years, with the development of brain science, many acupuncture clinical researchers have used multidisciplinary methods and techniques to perform acupuncture clinical research on cerebrosis. Up to now, many achievements have been obtained such as expanding studied disease entities, standardizing methods, identifying objects, and developing more and more treatment methods and in-depth mechanism research.

Objective To study the neuroelectrophysiological responsibility, mechanism and clinical application of auditory event-related potential (AERP) generated in bilateral auditory centers with ipsilateral and contralateral recordings. Methods 14 normal young adults were served as subjects. AERPs, including the responsibility, latencies, amplitudes and waveforms, were simultaneously recorded on ipsilateral and contralateral vertexes and analyzed. Results The latencies and amplitudes of AERPs did not show significicant difference statislically between ipsilateral and contralateral vertexes recordings. However, the responsibility of AERP recorded on ipsilateral vertex was more satisfied than that on contralateral vertex, which exhibited smoothing waves, discriminative wave peaks and little hetero-wave. Conclusion The origins of AERP in bilateral auditory centers were essentially symmetrical. Nevertheless, the responsibility of AERP recorded on ipsilateral vertex was more satisfied than that on contralateral vertex, which was related to the components of auditory subcortex, transmission of auditory nerve to bilateral centers and the contralateral inhibiting effect of medial olivo-cochlear system. The effects of multi-generation and multi-component of AERPs on the clinical application should be considered.

0.05).Conclusion The intervertebral fusion cage of n-HA/PA66 has good biocompatibility and osteo-conductibility.It may be the ideal interbody fusion cage.