1.Percutaneous radiofrequency thermocoagulation in the treatment of trigeminal neuralgia
Chinese Journal of Tissue Engineering Research 2007;0(44):-
Radiofrequency thermocoagulation technique,as a maturity procedure,has been used routinely for trigeminal neuralgia.Radiofrequency thermocoagulation has high rates of pain relief,a long duration of pain relief,and few serious perioperative complications.This technique very suits for old patients or patients with cardiovascular diseases.The common complications include numbness,absence of corneal reflex,and master weakness.Keratitis,dysesthesia and dolorosa greatly affect patients’ quality of life.Radiofrequency thermocoagulation is an effective and promising method in the treatment of trigeminal neuralgia.Practitioner should pay attention to pain relief and reducing complications and this will help to improve their quality of life.
2.Pharmacognostic Studies on Jinxianlian Ⅰ. Bencaologic Review, Resource Survey and Taxonomic Identification
Chun ZLLENG ; Yizhong HUANG ; Lianfang JI
Chinese Traditional and Herbal Drugs 1994;0(03):-
Result of the present study showed that Anoectochilus roxburghii (Wall. )I,indl. is the genuine speciescurrently used as folk medicine, while A, formosanus Hayata. is a different species with the same name ofJinxianlian. trhe distribution and ecological environment of Jinxianlian were described and an index of eightspecies of Anoectochilus Bl. were listed to distinguish their maln eharacteristic differences.
3.Percutaneous radiofrequency thermocoagulation for the treatment of different types of trigeminal neuralgia: Evaluation of quality of life and outcomes.
Yizhong, HUANG ; Jiaxiang, NI ; Baishan, WU ; Mingwei, HE ; Liqiang, YANG ; Qi, WANG
Journal of Huazhong University of Science and Technology (Medical Sciences) 2010;30(3):403-7
Radiofrequency thermocoagulation (RFT) of the gasserian ganglion is a routine and effective technique for the treatment of classical trigeminal neuralgia (CTN). In this study we compared its efficacy in patients with CTN and atypically symptomatic or mixed trigeminal neuralgia (MTN). Fifty-seven patients were treated with RFT for trigeminal neuralgia from June 2006 to February 2009. Thirty patients had CTN, and 27 had MTN. Outcomes were measured by using the visual analog pain scale (VAS) and patients' reports of quality of life (QOL), medication usage, and complications over a follow-up period of up to 3 years. Our results showed that the patients with MTN were younger, tended to have bilaterial involvement of the first division, and were unresponsive to treatment. All surgeries were completed smoothly. About 86.7% CTN patients and 48.1% MTN patients responded immediately to RFT. The VAS scores were significantly higher in the CTN group than in MTN group (P<0.05). Kaplan-Meier curves showed that 1-year, 2-year, and 3-year pain relief rates were 76.7%, 73.3%, and 73.3% in the CTN group and 46.6%, 41.4%, and 41.4% in the MTN group, respectively. The rates of pain relief for both groups leveled off at 2 years. Complications included numbness, dysesthesia, and anesthesia dolorosa. RFT did not cause any deaths and complications were low. The treatment was very effective for CTN and, to some degrees, effective for MTN. If numbness, dysesthesia, and anesthesia dolorosa are limited to the trigger area, QOL will be greatly improved.
4.Effect of the Gardenia extracts T9 on VP16 mRNA in herpes simplex virus type-1 infected mice's brains
Yizhong WANG ; Yujing SHI ; Yang HUANG ; Shanshan GUO ; Jing JIANG ; Dan SU ; Ye ZHAO ; Yingjie GAO ; Xiaolan CUI
Chinese Journal of Microbiology and Immunology 2008;28(6):515-518
Objective To investigate the effect of the Gardenia extracts T9 on herpes simplex virus (HSV) viral protein 16(VP16) in HSV-1 infected mice's brains and its potential anti-viral mechanism. Methods HSV-1 infection was induced in BALB/c mice, the expression of HSV VP16 was detected by RTPCR on the 4th, 7th, 10th, 14th, and 21st day. Results The expression of VP16 mRNA decreased in both groups of large and low doses compared with virus group at the same time. Conclusion Gardenia extracts T9 can down-regulate the expression of VP16 mRNA in HSV infected mice's brains, and it may be one of its anti-HSV mechanisms.
5.Percutaneous Radiofrequency Thermocoagulation for the Treatment of Different Types of Trigeminal Neuralgia: Evaluation of Quality of Life and Outcomes
HUANG YIZHONG ; NI JIAXIANG ; WU BAISHAN ; HE MINGWEI ; YANG LIQIANG ; WANG QI
Journal of Huazhong University of Science and Technology (Medical Sciences) 2010;30(3):403-407
Radiofrequency thermocoagulation(RFT)of the gasserian ganglion is a routine and effective technique for the treatment of classical trigeminal neuralgia(CTN).In this study we compared its efficacy in patients with CTN and atypically symptomatic or mixed trigeminal neuralgia(MTN).Fifty-seven patients were treated with RFT for trigeminal neuralgia from June 2006 to February 2009.Thirty patients had CTN,and 27 had MTN.Outcomes were measured by using the visual analog pain scale(VAS)and patients' reports of quality of life(QOL),medication usage,and complications over a follow-up period of up to 3 years.Our results showed that the patients with MTN were younger,tended to have bilaterial involvement of the first division,and were unresponsive to treatment.All surgeries were completed smoothly.About 86.7% CTN patients and 48.1% MTN patients responded immediately to RFT.The VAS scores were significantly higher in the CTN group than in MTN group(P<0.05).Kaplan-Meier curves showed that 1-year,2-year,and 3-year pain relief rates were 76.7%,73.3%,and 73.3% in the CTN group and 46.6%,41.4%,and 41.4% in the MTN group,respectively.The rates of pain relief for both groups leveled off at 2 years.Complications included numbness,dysesthesia,and anesthesia dolorosa.RFT did not cause any deaths and complications were low.The treatment was very effective for CTN and,to some degrees,effective for MTN.If numbness,dysesthesia,and anesthesia dolorosa are limited to the trigger area,QOL will be greatly improved.
6.Relationship between serum miR-21 and miR-27b levels and prognosis of patients with renal clear cell carcinoma
Shuang CHEN ; Na YANG ; Yudong HUANG ; Xiangfeng KONG ; Jintao LI ; Yizhong TANG ; Kex-Iong MA ; Yangyang ZHANG ; Yuandong ZHANG ; Chengde REN
The Journal of Practical Medicine 2024;40(3):343-347
Objective To explore the relationship between serum miRNA-21 and miR-27b levels and prognosis of patients with renal clear cell carcinoma.Methods A total of 118 patients with renal clear cell carcinoma admitted to the Qinghai University Hospital from February 2019 to April 2021 were selected as the study subjects,and another 118 healthy patients in the same period as the control group.Real time fluorescence quantitative polymerase chain reaction(PCR)was used to detect the expression of miR-21 and miR-27b in the serum of all subjects.The relative expression levels of serum miR-21 and miR-27b between the patients with renal clear cell carcinoma and healthy control patients were compared.The expression and correlation of serum miR-21 and miR-27b in the patients with renal clear cell carcinoma of different pathological stages and Fuhrman grading were analyzed.The relationship between the expression of serum miR-21 and miR-27b and the survival and prognosis of the patients was explored as well.Results The expression levels of serum miR-21 and miR-27b in the patients with renal clear cell carcinoma were higher than those in the healthy control group(P<0.05).The serum miR-21 expression level in stage Ⅲ patients was higher than in stageⅠ(P<0.05),while the serum miR-21 expression level in the stage Ⅳ patients was higher than that in stagesⅠ,Ⅱ,and Ⅲ(P<0.05).The expression level of miR-27b in the serum of patients gradually increased across the four stages,with a significant difference(P<0.05).The pathological staging was positively correlated with the expression of miR-21 and miR-27b(P<0.001).The expression levels of miR-21 and miR-27b in serum of patients gradually increased across grades Ⅰ,Ⅱ and Ⅲ by Fuhrman grading,with significant difference(P<0.05).Fuhrman grading was positively correlated with the serum miR-21 and miR-27b expression(P<0.001).There was a statistically significant difference in the survival curve between the miR-21 high expression group and the low expression group(P<0.05).There was a statistically significant difference in the survival curve between the high expression group and the low expression group of miR-27b(P<0.05).Conclusion The expression levels of serum miR-21 and miR-27b in patients with renal clear cell carcinoma is indicative of the progression and prognosis of the patient's condition.
7. Study on the disease burden of cancer attributed to the dietary inorganic arsenic exposure in Chinese population in 2013
Yujing ZHOU ; Baina WANGYI ; Yan SONG ; Yizhong YAN ; Jiao HUANG ; Lei ZHANG ; Sheng WEI
Chinese Journal of Preventive Medicine 2019;53(12):1247-1252
Objective:
To estimate the burden attributed to the dietary inorganic arsenic exposure with lung cancer, bladder cancer and skin cancer as end points.
Methods:
Inorganic arsenic, food or diet were used as Chinese keywords and arsenic, food and China were used as English keywords to search for literatures related to the dietary inorganic arsenic exposure published by China National Knowledge Infrastructure, Wanfang Data Knowledge Service Platform and PubMed Database. Using the data from the China National Nutrition and Health Survey (CNNHS) in 2002 to estimate the dietary inorganic arsenic exposure in Chinese residents. The annual cancer cases attributed to the dietary inorganic arsenic exposure were calculated based on the data from Chinese Cancer Registry Annual Report in 2013. The disability adjusted life year (DALY) was calculated using tools built by WHO.
Results:
The total DALY of cancer caused by the dietary inorganic arsenic exposure was 419.4 thousand, and the DALY rate was 31.47 per 100 000. The DALY of lung cancer in males and females was 237.7 thousand and 102.5 thousand. The DALY of bladder cancer in males and females was 13.2 thousand and 3.9 thousand. The DALY of skin cancer in males and females was 29.4 thousand and 32.8 thousand.
Conclusion
In 2013, the Chinese population had a lower burden of cancer due to the dietary exposure to inorganic arsenic.