Metoclopramide (MCP) stimulating test for prolactin (PRL) secretion was performed on 5 normally cycling women (early follicular phase, EF), 4 early puerperal women and 17 patients with galactorrhea and anovulation. The mean serum PRL level in EF group increased more than 7-fold of the mean basal PRL level after MCP injection but only 1.51 and 1.28 times of that in postpartum and galactorrhea-anovulation groups respectively. However, no significant difference was noted between the pituitary tumor and non-tumor groups, thus MCP stimulating test for PRL secretion was not helpful to differential diagnosis between functional hyperprolactinemia and microprolactinoma. The relationship and management of these two clinical entities were also discussed.

Objective To investigate the clinical effect of modified seton therapy with counterparts drainage on high anal fistula.Methods One hundred and forty-four patients with high anal fistula were randomly assigned to the observed group (modified seton therapy with counterparts drainage,74 cases) and the control group (the traditional high hanging line therapy,70 cases).The clinical efficacy,visual analogue scale (VAS),Wexner incontinence score,fecal incontinence quality of life index (FIQLI) score were compared.Results Observed group were cured with 40 cases,improved with 27 cases,ineffective with 7 cases,control group were cured with 25 cases,improved with 43 cases,ineffective with 2 cases,difference between two groups was statistically significant (P ＜ 0.01).The healing time in observed group was significantly shorter than that in control group(P＜ 0.01).The VAS after therapy 1,7 d in observed group was significantly lower than that in control group (P ＜ 0.05).The Wexner incontinence score,FIQLI score before therapy was no significant difference between two groups (P ＞0.05).The Wexner incontinence score,FIQLI-lifestyle score,FIQLI-depression/self-perception score,FIQLI-distress score after therapy 3 months in observed group was significantly higher than that before therapy and control group after therapy 3 months (P ＜ 0.05),there was no significant difference Wexner incontinence score and FIQLI score before therapy compared with therapy 3 months in control group (P ＞ 0.05).Conclusions Modified seton therapy with counterparts drainage may be a valid treatment for high anal fistula.The successful outcome is associated with significant improvement in quality of life.

Objective: To explore the effect of perfectionism on depression using anxiety as a controllng variable,and to find possible personality moderators.Methods: 407 undergraduate students from 8 universities in Beijing and Xi'an completed a battery of questionnaires,including Frost Multidimensional Perfectionism Scale(FMPS),Beck Depression Inventory(BDI),Personality Adjective Checklist(PACL) and Self-rated Anxiety Scale(SAS).Results: Hierarchical Regression Analysis confirmed the effects of two negative perfectionism dimensions hesitating over actions and concerning over mistakes,on depression after controlling anxiety.The effect of organization on depression was moderated by the personality trait of cooperation.Conclusion: Dimensions of perfectionism have diverse effects on depression.Psychological intervention should be carried out according to individual characteristics.

Ten years had passed for the molecular targeted therapy since approval by the U.S.Food and Drug Administration of the first monoclonal antibody-Rituximab,for the treatment of the B-cell non-Hodgkin's lymphomas with positive CD20- The targeting therapy,which may be a promising approach in the future,has significantly improved the patients'qualities of lives and prognosis because it has higher selectivity and less adverse effects than current chemotherapy and radiotherapy.In the past decade,with the fast development of novel targeting drugs and extension of therapeutic fields,the limitations associated with the targeted treatments were received attentions.

Objective: To examine the reliability and validity of MBI-SS and discuss the academic characteristics that affect burnout. Methods: 353 undergraduate students were administrated MBI-SS and Academic Characteristic Survey. Results: Confirmatory factor analyses showed that the expected three-factor structure of the adapted versions of the MBI- Students Survey (including Exhaustion, Cynicism, and Reduced Efficacy) fitted to the data. Exploratory factor analyses showed that the Academic Characteristic Survey includes six dimensions. The result of Regression showed that 44.4% variance of student burnout can be explained by Academic Characteristics. Conclusion: Student burnout includes three dimensions: Exhaustion, Cynicism and Reduced efficacy. Academic self-efficacy,academic stress,relationship with teachers and relationship with fellow students are significant predictors for student burnout.

Objective To discuss the influence of Danshen Chuanxiongqin injection on renal function and relevant indexes of urine in rats with sepsis -induced acute kidney injury(AKI))caused by cecal ligation and punc-ture (CLP).Methods Seventy male Sprague Dawley(SD)rats were randomly divided by random number table into normal group,sham -operation group,sepsis group and Danshen Chuanxiongqin group.The three latter groups were divided into groups of 6,12,24,48 -hour subgroups,five rats in each subgroup.Danshen Chuanxiongqin group was injected with Danshen Chuanxiongqin injection at 0,24,48h from caudal vein seperately,and the other groups were injected with saline solution.The blood and urine were collected in the set four time points.The relevant indexes like serum creatinine (SCr),blood urea nitrogen(BUN),IL -6 and TNF -αwere tested and kidney injury molecule -1 (KIM-1)and neutrophil gelatinase associated lipocalin (NGAL)were detected.Changes of renal pathology were observed under light microscope.Results In the sepsis group,the concentrations of SCr and BUN 6h after CLP star-ted to rise,reached peak in 24h to (96.31 ±12.64)μmol/L and (27.17 ±4.98)mmol/L,and decreased in 48 h, while concentrations of IL -6 and TNF -αwere reached peak in 12h (28.45 ±3.22)pg/mL and 6h (72.35 ± 10.84)pg/mL respectively,and then decreased,which were all higher than those in the normal group and sham -operation group (P <0.05).After Danshen Chuanxiongqin injection therapy,the concentrations of Scr,BUN,IL -6 and TNF -αin 6h,12h,24h and 48 h were all lower than those in the corresponding points in time in the sepsis mod-el group,and reached minimum values[(14.89 ±2.41)μmol/L,(17.29 ±3.37)mmol/L,(14.89 ±2.41)pg/mL, (17.29 ±3.37)pg/mL,all P <0.05].The contents of KIM-1 and NGAL 6 h after CLP started to increase,reached peak in 24h (5.47 ±0.39)ng/mL and 12h (6.35 ±0.81)ng/mL respectively,and decreased in the sepsis group were all remarkably higher than those in the normal group and sham -operation group.After given Danshen Chuanx-iongqin injection,the contents of KIM-1 and NGAL in 6h,12h,24h and 48h were greatly lower than those in the corresponding points in time in the sepsis group,reached minimum values[(2.27 ±0.16)ng/mL,(2.03 ±0.27)ng/mL,all P <0.05)].In the Danshen Chuanxiongqin group,the change of renal pathology was better than that of the sepsis group in 12h.Conclusion Danshen Chuanxiongqin injection plays the role of renal protection in AKI caused by sepsis.

Objective:To evaluate the security, efficacy and side effects of E_2 transdermal patch (Fem-7) in the treatment of menopausal syndrome. Methods:A total of 60 cases with menopausal syndrome (blood serum FSH >30 U/L,E_2 <109.8 pmol/L) were randomly divided into treatment group ( Fem-7 group) and control group (estrodiol valerate (E_2V) group) for 12 weeks treatment. Fem-7 group changed patch every 7 days and took the 2 mg medroxyprogesterone (MPA) every day. While the E_2V group took the 2 mg MPA and 1.5 mg E_2 V every day. Serum E_2, FSH, lipoprotein and coagulation function were evaluated at baseline and at the 12th week of the treatment. In addition, menopausal symptoms and some other index of security and side effects were also observed. Results:Kupperman indix in both groups was decreased and the mean value of E_2 was increased obviously. Hepatic function, renal function, coagulation function and blood glucose were no obvious change. Lipoproteina was descended markedly in Fem-7 group. Other index of security in both groups was no obvious change. Conclusions:Fem-7 patch is secure and valid for relieving symptom of menopause, especially for the women who is not sutable for oral medication.

Objective To explore conduct disorder tendency and it's influence factors on secondary school students. Methods 669 students of grade 1 in Dezhou Vocational and Technical College were investigated by Conduct Disorder Tendency Questionnaire, Revised Version of MBI-SS and SRHMS Version1.0. Results The secondary vocational school students' scores on violation tendency, addiction tendency and aggression tendency were 11.51±4.08,5.90±2.68 and 6.68±2.63,and were significant different from vocational college students or high school students(addiction tendency:F(2, 1578)=7.48,P =0.001;aggression tendency:F(2, 1579)=24.40,P <0.001). There existed great capable difference of conduct disorder according to genders ( t(643)>3.85,P <0.001).Conduct disorder tendency of secondary vocational students' was positive correlated with their learning burnout (Pearson correlation coefficient was between 0.16 and 0.52 for each pair), but negative correlated with mental health(Pearson correlation coefficient was between -0.13 and -0.27 for each pair). The linear regression showed that some dimensions of learning burnout and self-rated mental health predicted students' conduct disorder tendency. Conclusion Conduct disorder tendency of secondary vocational students is affected by their learning burnout and mental health.

Objective To investigate the prevalence of occupational asthma,airway inflammation and analyze the risk factors for workers exposed to isocyanates.Methods A cross-sectional study was applied.Totally 429 isocyanates exposed workers were surveyed and the prevalence of occupational asthma and airway inflammation situation were examined by questionnaire,physical examination and laboratory tests.Multivariate logistic regression was applied to analyze the possible risk factors of isocyanate-induced occupational asthma.Results (1) A total of 366 patients with complete data were included in the study,and finally 11 cases were diagnosed as isocyanate-induced occupational asthma with a prevalence of 3.0％.(2) Neutrophil percentage in the induced sputum of occupational asthma increased significantly [42.00％ (34.00％-55.00％) before work and 59.00％ (51.00％-70.00％) after work (Z =-2.940.P ＜ 0.05)].(3) Length of service (OR =3.096,P =0.025) and rhinitis (OR =1.901,P =0.008) were independent dangerous factors,and protective measures (OR =0.074,P =0.015) was protective factors to isocyanateinduced occupational asthma.Conclusions Neutrophilic inflammation can be triggered by isocyanate exposure.Regular health examinations,effective protective measures can reduce the prevalence of isocyanateinduced occupational asthma.

Objective: To examine the applicability of Perfectionistic Self-Presentation Scale (PSPS) in Chinese college students, and its relationship with self-esteem.Methods: A sample of 187 undergraduates completed the preliminary back-translated Chinese version of PSPS.Another sample of 482 undergraduates completed a battery of structured questionnaires including the final Chinese version of PSPS, Frost Multidimensional Perfectionism Scale (FMPS) and the Self-Esteem Scale (SES).Reliability and validity of PSPS were analyzed and a hierarchical regression analysis was processed to examine the additional contribution of perfectionistic self-presentation in predicting self-esteem after controlling for perfectionistic traits.Results: All psychometric indices of the revised PSPS were satisfactory (the Cronbach ?index for the three subscales were 0.742, 0.705 and 0.681).The three sub-dimensions, i.e.perfection self-promotion, non-display of perfection and non-disclosure of perfection, all had significant contributions(?F=9.891,P