Nerve injury as a kind of tissue damage, inevitably stimulates nerve tissue inflammatory reaction, mediates neural tissue repair and regeneration, and participates in the occurrence of chronic pain. The high mobility group protein B1 (HMGB1) and Toll-like receptor 4 (TLR4) in neurological pain plays an important role, HMGB1-TLR4 pathway is involved in the initiation and progression of neuropathy pain. If the mechanism of HMGB1-TLR4 pathway in the neurological pain is identified, it can provide an effective pain-relieving methods and new target for drugs.

Objective To report the 5-10 years clinical follow-up results of patients who underwent percutaneous balloon mitral valvuloplasty (PBMV) in order to verify the interim and long term results, as well as the incidence and risk factors of restenosis. Methods From January 1996 to June 2001, 83 patients including 12 males and 71 females, with age of 20-68 years old (mean age of 41.56?10.68 years old). The clinical data and echocardiography before and 2 days after PBMV, and 5-10 years (mean 3.1?2.4 years) follow up were studied retrospectively by the SPSS software. Results The mitral valve area (MVA) increased from 1.05?50.23 cm2 before PBMV to 1.98?0.27 cm2 2 days after PBMV (P

Objective To evaluate the effectiveness of ultrafiltration in acute heart failure syndrome(AHFS).Methods Da-tabases including PubMed,WanFang and CBM were searched to collect RCTs on ultrafiltration in AHFS.Two reviewers independ-ently screened literature according to the inclusion and exclusion criteria,extracted data,and evaluated the methodological quality of the included studies.Then the Meta-analysis was conducted using RevMan5.3.Results A total of 14 trials involving 755 patients were included.The results of Meta-analyses showed that ultrafiltration was not associated with significantly decreased risk of all-cause mortality(RR=0.95,95%CI :0.65 to 1.38,P =0.77),rehospitalization(RR =0.78,95%CI :0.49 to 1.24,P =0.29)and change in serum creatinine(WMD = 0.02 mg/dL,95%CI :- 0.18 to 0.21,P = 0.87 ).However,there was significantly more weight loss(WMD =1.32 kg,95%CI :0.29 to 2.35,P =0.01)and net fluid removal(WMD =1.27 kg,95%CI :0.43 to 2.12,P =0.003)in the ultrafiltration group.Conclusion For patients with AHFS,ultrafiltration is effective in reducing fluid retention,with no significant benefits in renal function preservation,mortality and rehospitalization.

10.3969/j.issn.2095-4344.2013.24.005

Objective To explore the causes and possible treatment for subacute coronary stent thrombosis (SST) after percutaneous coronary interventions (PCI) in the races of Han, Uygur and Kazak in Xin Jiang Province. Methods The variables of hemodynamic, blood coagulation, lesions characteristics, the course of operation and relative treatment of 21 cases of different races (Han. Uygur and Kazak) were reviewed and underwent logistic regression analysis. Results The incidence of SST were higher in the Uygur and the Kazak people than that in the Han group after PCI (1.4% vs 0.47%; 5.4% vs 0.47%, P

Objective To explore the application of echocardiography to guide interatrial septal puncture and evaluate the clinical effect in PBMV. Methods One hundren and sixty two patients were categorized into two groups according to whether echocardiography was applied in atrial septal puncture and real time monitoring. X-ray fluoroscopy guidence was used during atrial septal puncture in group 1 and in group 2, X-ray as well as echocardiography were used. The clinical outcomes were analyzed and contrasted between the 2 group. Results (1) The mean mitral pressure gradient dropped obviously in group 2 immediately after PBMV compared with group 1 (6.4?2.6 mm?Hg vs 10.2?3.7 mm?Hg,P

Objective To compare the difference in incidence and therapeutic outcomes of coronary calcification between old Han and Uygur CHD patients in Xinjiang rovince after percutaneous coronary intervention.Methods We retrospectively analyzed the coronary angiography results and complications after PCI in the aged Han and Uygur CHD(age≥60) patients who had received PCI therapy from January 2005 to December 2006 in our hospital.Results Among 545 patients(Han 282,Uygur 263),the overall detection rate of coronary artery calcification was 37.6%,and the incidence of coronary calcification in the Uygur group was significantly higher than in the Han patients group(49.3% vs 29.8%,P0.05).There was higher rate of coronary slow flow in the Uygur group than in the Han group(28.7% vs 9.3%,P0.05).Conclusion Coronary calcification can be found more often in old Uygur CHD patients compared with Han patients in Xinjiang.The incidence of coronary artery dissection and slow flow was higher in the Uygur patients than in Han patients.Special comcerns in avoiding coronary artery dissection and slow flow should be applied to Uygur patients.

Objective Compare and analyze the characteristics of the coronary angiography between Han nationality and Uygur nationality in Xinjiang autonomous region Methods 2?200 clinical data and angiographic data from 1991 to 1999 were reviewed There were divided into two groups according to different nationality The extent of the lesions and the proximal calibres of coronary artery were measured and compared Results The proximal calibres of coronary arteries of Uygurs are greater than those of Hans The lesions of Uygurs′ coronary heart disease (CHD) patients are more severe than Hans′: more three branch lesion, more C type lesion and total occlusion cases. There are statistical differences between two nationalities Conclusion Proximal calibres of coronary branches of Uygures are bigger than Hans, but Uygur patients suffer more severe lesions of coronary arteries as compared with Hans

Objective To evaluate the therapeutic effect of transcatheter closure of secundum atrial septal defect (ASD) and patent ductus arterious (PDA) using Amplatzer device Methods Twenty third patients (19 ASD, 4 PDA) were treated with Amplatzer device through the pecutaneous procedure under fluoroscopy,angiography and TTE Results The success rate was 100% No residual shunts were found in 21 cases after the procedure 24 hours and 1 week later TTE and X ray examination showed that no residal shunts in all cases and both pulmonary vascularity and cardiac silhouette were improved after the procedure half a year Conclusion Transcatheter closure of ASD and PDA using Amplatzer device is an efficent method, the operation is simple with a high sucess rate and a good occlusion effect

Objective To discuss the optimal time of “early PCI” by analyzing clinical short-term outcome of PCI in non ST-segment elevation acute coronary syndromes (ACS). Methods We selected 150 non-ST segment elevation ACS patients who had received PCI from 24 h to 4 weeks after the symptoms occurred. They were devided into 3 groups ( h) according to the interval between outbreak and PCI therapy. The success rate of PCI, improved chest pain, alteration of TIMI flow grades, and the ratio of adverse cardiovascular events during and after the procedure were compared. Results No significant differences were found in the 3 groups of patients with respect to the success rate, improved chest pain, alteration of TIMI flow grade. But the ratio of adverse cardiovascular events during the procedure in the 72 h group. So the PCI during 24-72 h in non ST-segment elevation ACS is safe and economical.