1.Effect of madopar combined with entacapone administration on plasma homocysteine level in patients with Parkinson's disease
Yan WU ; Juan DU ; Yisheng REN
Journal of Clinical Neurology 2016;29(5):333-335
Objective To investigate the effect of madopar combined with entacapone administration on plasma homocystein ( Hcy) level in patients with Parkinson's disease ( PD) .Methods Thirty healthy person were selected as a control group, 20 PD subjects with no levodopa ( LD) taking were as no treatment group, 63 subjects with madopar were as madopar group and 49 subjects with madopar combining entacapone were as combination group. Meanwhile levodopa concentration in peripheral blood and Unified PD Rating Scale Ⅲ ( UPDRSⅢ) score were measured.The plasma Hcy levels of all the researchers were detected.Results The L-dopa concentration in plasma of combination group was statistically significantly higher than that of madopar group ( P<0.05 ) .The score of UPDRSⅢscale of madopar group and combination group were significantly lower than that of madopar group ( all P<0.05).Compared with control group, the Hcy concentration in non-treatment group, madopar group and combination group were significantly increased ( all P<0.05 ) .And the Hcy concentration in madopar group was significantly higher than those in none treatment group and combination group ( all P<0.05 ) .Conclusion Madopar combined with entacapone therapy can significantly reduce plasma Hcy levels in patients with PD, which may be beneficial to the treatment of PD.
2.Theory and Method of Analysis on Systematic Hypothesis for Adverse Drug Events
Hanyong ZHU ; Longjing WEI ; Yisheng REN
China Pharmacy 2001;0(11):-
OBJECTIVE: To establish the theory and method for the analysis of systematic hypothesis on adverse drugs events. METHODS: System of causal analysis of adverse drug events and analytical methods on systematic hypothesis were established by applying systematical and scientific thoughts; and the application of which in the quality analysis of oral solid preparations and injections were explained. RESULTS: The system of causal analysis consists of subsystems of drug standard deficits, problems of drugs quality, adverse drugs reactions, medication errors and drug abuse subsystems. The analysis on systematic hypothesis consisted of 4 steps: producing signal, raising the hypothesis, demonstrating, and drawing the conclusions. CONCLUSION: The causal analysis system of adverse drug events and analytical methods on systematic hypothesis combined not only reductionism with holism but also analysis with synthesis, which can help to solve the complicated matter in clinical medication.
3.Pharmaceutical Evaluation Factors of Clinical Drugs
Hanyong ZHU ; Longjing WEI ; Yisheng REN
China Pharmacy 2007;0(26):-
OBJECTIVE: To lay a basis on constructing theory and method of the pharmaceutical evaluation.METHODS: By synthesizing the literature and experience,the authors summarized and explained the pharmaceutical evaluation factors which included rationality of preparations,quality controllability,and delivery efficacy etc.RESULTS: The factors of rationality of preparations included the choice of dosage form,specification and package amount;the factors of quality controllability included active constituent,foreign matter,package and stability,and the factors of delivery efficacy included dissolution or releasing degree and device packaging,CONCLUSION: This system of evaluation factors is systematic,dynamic and practical.
4.Effect of ischemia-reperfusion on calcium accumulation and ultrastructure alteration in rabbit brain.
Jiashun REN ; Min BI ; Yisheng CHEN
Chinese Journal of Anesthesiology 1994;0(05):-
Using the model of the rabbit brain ischemia the intracellular calcium accumulation and ultrastructure alteration of cerebral cortex were observed. The results indicated that the longer the ischemia reperfusion time,the more was the calcium accumulation and ultrastructure alteration in cerebral cortex. It is revealed that calcium plays an important role in the brain Injury induced by ischemia-reperfusion. The mechanism of brain injury related to calci- um was diseussed.
5.Development of PET scanner for small animals
Ying LIU ; Qingli QIAO ; Qiushi REN ; Yisheng ZHU
Chinese Medical Equipment Journal 1993;0(06):-
In comparison with the clinical PET scanner,PET scanner for small animals puts forward a higher demand in spacial resolution and sensitivity. This article describes the development of the PET scanner for small animals and compares the characteristics of several kinds of contemporary typical PET scanners for small animals in different aspects based on the development of detectors. Meanwhile,it also introduces the development of the detectors designed for measuring depth of interaction (DTC) to reduce parallax error.
6.Removal of artifacts from EEG signal.
Xiaoyan DU ; Yingjie LI ; Yisheng ZHU ; Qiushi REN ; Lun ZHAO
Journal of Biomedical Engineering 2008;25(2):464-471
As a kind of physiological signals, the electroencephalogram (EEG) represents the electrical activity of the brain. Because of its higher time-varying sensitivity, EEG is susceptible to many artifacts, such as eye-movements, blinks, cardiac signals, muscle noise. These noises in recording EEG pose a major embarrassment for EEG interpretation and disposal. A number of methods have been proposed to overcome this problem, ranging from the rejection of various artifacts to the effect estimate of removing artifacts. This paper reviews many kinds of methods for artifact rejection in the EEC recently, including regression-based methods, artifact subtraction, principal component analysis (PCA), independent component analysis (ICA) and wavelet transform. The specific assumptions of each method and its advantage/disadvantage are also summarized.
Artifacts
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Brain
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physiology
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Electroencephalography
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methods
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Humans
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Principal Component Analysis
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Signal Processing, Computer-Assisted
7.Effect of comprehensive medical goal appraisal on hand hygiene compli-ance rate of health care workers
Liuyi LI ; Jianfeng YUAN ; Yanchun ZHAO ; Jianxia JIA ; Xiuli ZHAO ; Junhong REN ; Huixue JIA ; Ling LI ; Xi YAO ; Huan YIN ; Yisheng PAN
Chinese Journal of Infection Control 2015;(1):16-19
Objective To evaluate the comprehensive medical goal appraisal system on hand hygiene compliance rate of health care workers(HCWs).Methods Comprehensive medical goal appraisal system was adopted to inter-vene hand hygiene compliance rate of HCWs in a comprehensive hospital ,hand hygiene compliance rates of HCWs and consumption of instant hand sanitizer per bed-day before (December 2012)and after intervention (January 2013-June 2014)were compared.Results Hand hygiene compliance rate after intervention was higher than before interven-tion (85.17% [18 208/21 379]vs 39.92%[853/2 137]),hand hygiene compliance rate enhanced by 113.35%(χ2 =2 590. 81,P <0.001).Hand hygiene compliance rates of HCWs of different departments,different occupations and different hand hygiene moments were all higher than before intervention (all P <0.001);after intervention ,hand hygiene compliance rate revealed a increased tendency,and has maintained high since October 2013 (>90%),consumption of instant hand sanitizer before and after intervention was 7.24 mL/bed-day(4 200 L/579 841 bed-day)and 10.54 mL/bed-day(9 323.5L/884 489 bed-day)respectively,the consumption after intervention increased by 45.58% compared with that before intervention. Conclusion Comprehensive medical goal appraisal can effectively enhance hand hygiene compliance rate ,and maintains at a high level;the measure can affect hand hygiene behavior of HCWs by hawthorne effect,and is an effective and long-term measure to improve hand hygiene compliance of HCWs.