Objective To study the relationship between the genetic polymorphism of interleukine-6 (IL-6)-174 and the response to benazepril treatment in patients with hypertensive renal damage. Methods Two hundred and eighty-four patients with hypertension were enrolled in this study. The hypertensive renal damage was defined by the measurement of urinary albumin excretion rate (UAER). One hundred and sixty healthy subjects were enrolled simultaneously as control group. Blood samples were obtained from all the subjects, and plasma levels of IL-6 and the genotype of gene IL-6-174 were detected. The patients with hypertensive renal damage were treated with benazepril for 16 weeks. The responses were evaluated by the changes of UAER level to benazepril in different genotypes. Results Genotype CC was the most common of the gene IL-6-174 in patients with hypertension, followed by GG and GC successively, with the G/C allele frequency of 47%and 53%(P<0.05), while in patients with hypertensive renal damage, GG was the most common genotype of the gene IL-6-174, followed by GC and CC successively, with the G/C allele frequency of 68%and 32%(P<0.05). After benazepril treatment, the UAER was decreased most in patients with genotype CC, followed by GC and GG successively ( P<0.05). Conclusion The G allele frequency of the gene IL-6-174 is related with hypertensive renal damage in patients in Ningxia, with GG as the most common genotype. The patients with CC genotype have the best response to benazepril treatment, with most decreased UAER.

Objective: To study the hemodynamic changes of fetal umbilical artery (UA) and middle cerebral artery (MCA) and its influence on fetal outcome using color Doppler ultrasound. Methods: Fifty pregnant women who underwent color Doppler ultrasound examination in Zhejiang Xin'an International Hospital from June to December 2018 with normal prenatal examination were selected as control group, and 80 pregnant women with oligohydramnios during the same period of pregnancy were selected as observation group. Color Doppler ultrasound examination was performed on both groups of pregnant women. The results of color Doppler ultrasound examination were compared between the two groups of pregnant women, and the fetal prognosis was followed up. Results: Compared with the control group, the peak systolic velocity/end diastolic velocity (S/D), resistance index (RI) and pulsatility index (PI) values of UA in the observation group were significantly increased, while the S/D, RI and PI values of MCA were significantly decreased, and there were significant differences (P < 0.05). In addition, UA of 34 cases (42.5%) in observation group had S/D ≥ 3, which was much higher than that of 8 cases (16.0%) in control group, and there was significant difference (P < 0.05). The difference between the two groups was statistically significant (P < 0.05). The incidence of fetal distress, intrauterine growth retardation (IUGR) and Apgar < 4 points in observation group were significantly higher than those in control group [26.2%(21/80) vs. 12.0%(6/50), 15.0%(12/80) vs. 2.0%(1/50), 7.5% (6/80) vs. 0], and the difference were statistically significant (P < 0.05). Conclusions Prenatal color Doppler ultrasound can accurately detect the hemodynamic indexes of UA and MCA, predict the fetal intrauterine development, evaluate the fetal outcome, and provide scientific basis for clinical diagnosis.

ObjectiveTo investigate the clinical effect of vitamin E in the treatment of nonalcoholic fatty liver disease (NAFLD) in children. MethodsPubMed, Web of Science, The Cochran Library, Embase, OVID/NEJM, CNKI, and Wanfang Data were searched for the articles on vitamin E in the treatment of NAFLD in children published up to December 2019. The data of 8 parameters were analyzed, i.e., body mass index (BMI), liver enzymes ［alanine aminotransferase (ALT) and aspartate aminotransferase (AST)］, blood lipid levels ［triglyceride (TG), total cholesterol (TC), low-density lipoprotein (LDL), and high-density lipoprotein (HDL)］, and remission rate of hepatic steatosis. RevMan 5.3 was used to perform a Meta-analysis. Continuous variables were analyzed by standardized mean difference (SMD) and 95% confidence interval (CI), and the changes after intervention were analyzed; categorical variables were analyzed by risk difference (RD) and 95%CI. A fixed effects model was used for homogeneous data, and a random effects model was used for heterogeneous data. Funnel plots were used to evaluate publication bias. ResultsA total of 599 articles were retrieved, among which 9 were included in the Meta-analysis, with 607 subjects in total. Vitamin E significantly improved the level of ALT (SMD = -0.27, 95%CI: -0.48 to -0.06, P=0.01), but it did not improve the levels of BMI (SMD=-0.09, 95%CI: -0.28 to 0.10, P=0.34), AST (SMD=-020, 95%CI: -0.42 to 0.02, P=0.07), TG (SMD=-0.19, 95%CI: -0.51 to 0.12, P=0.22), TCHO (SMD=-0.11, 95%CI: -0.31 to 0.08, P=0.24), HDL (SMD=-0.02, 95%CI: -0.27 to 0.23, P=0.88), LDL (SMD= -0.04, 95%CI: -0.27 to 019, P=072), and the remission rate of hepatic steatosis (RD=0.06, 95%CI: -0.05 to 0.17, P=0.29). ConclusionVitamin E can significantly improve the level of ALT in children with NAFLD and can be considered as an adjuvant drug for clinical treatment.

Objective:To evaluate the clinical value of three-dimensional ultrasound imaging in the localization and shaping of intrauterine contraceptive device.Methods:A total of 46 patients with abnormal intrauterine contraceptive device positions who admitted to Xin'an International Hospital from May 2018 to May 2019 were selected.All patients were examined by two-dimensional ultrasound and three-dimensional ultrasound, and the results were compared with the surgical results of the patients.The application value of three-dimensional ultrasound in the localization and shaping of intrauterine contraceptive device was analyzed.Results:By surgery pathology diagnosed with synthetic in palace in 2 cases, synthetic down in 29 cases, synthetic part or security in 15 cases.The two-dimensional ultrasonic diagnosis of patients with synthetic in the palace in 2 cases, synthetic down in 30 cases, synthetic part or security embedded in 11 cases, abnormal suspicious uncertain in 3 cases, 3 cases of missed diagnosis, 1 case of misdiagnosis.The three-dimensional ultrasound diagnosis in patients with synthetic in the palace in 2 cases, synthetic down in 29 cases, synthetic part or security embedded in 14 cases, abnormal suspicious uncertain in 1 case, no misdiagnosis, missed diagnosis in 1 case, pure synthetic down patients can be removed under hysteroscopy.Patients with IUD outside the uterus were removed laparoscopically without IUD rupture or residual fragments.And synthetic guided by hysteroscopy in patients with incarcerated during extraction, 3 cases of synthetic fracture or residual fragments occurring and compared with synthetic down the difference was statistically significant (χ 2=4.982, P<0.05), compared with the synthetic located outside the uterus, the difference was statistically significant (χ 2=4.634, P<0.05), the incidence of completely bypassed economizer fracture or residual fragments was higher than partial incarceration patients (χ 2=4.845, P<0.05). Conclusion:Three-dimensional ultrasound has higher accuracy in positioning and shaping the intrauterine contraceptive device of patients, which can guide clinicians to choose the treatment program.

Objective:To investigate the application value of three-dimensional power Doppler ultrasound in the clinical diagnosis of endometrial polyps.Methods:Seventy-three patients with suspected endometrial lesions admitted to Xin'an International Hospital of Zhejiang Province from June 2018 to June 2019 were enrolled.Three-dimensional power Doppler ultrasound and hysteroscopy were performed on the patients.The results of hysteroscopy and three-dimensional power Doppler ultrasound diagnosis and ROC curve were analyzed.Results:In 73 patients, the pathological diagnosis showed that there were 35 cases in the non-polyp group and 38 cases in the polyp group.The area and standard error under the three-dimensional Doppler ultrasound curve were 0.93 and 0.04, respectively.The area under the hysteroscopic curve and the standard error were 0.92.0.03, respectively, there was no statistically significant difference in the area of ROC curve between the two diagnostic methods ( P=0.051). Conclusion:Three-dimensional power Doppler ultrasound in the diagnosis of endometrial polyps is highly accurate and similar to hysteroscopy.In the clinical examination of endometrial polyps, three-dimensional energy Doppler ultrasonography is worthy of promotion and application.

Objective To study the correlation between the genetic polymorphism of tumor necrosis factor-α(TNF-α)-308 with benazepril treatment response in the patients with hypertensive renal damage in Ningxia area.Methods Two hundred and eighty-four patients initially diagnosed as hypertension were enrolled and the hypertensive renal damage defined by the measurement of urinary albumin excretion rate(UAER).At the same time 160 individuals undergoing healthy physical examination were selected as the normal blood pressure control group.The plasma samples were obtained from all the subjects,and plasma level of TNF-α and TNF-α-308 gene polymorphism were detected.Then the patients with hypertensive renal damage were interfered with benazepril as one of the antihypertensive drugs,and the treatment response of different TNF-α-308 genotypes to benazepril was observed,and the comparative analysis was performed.Results Among the TNF-α-308 genotypes in the patients with simple hypertension,genotype GA was the most common,followed by GG and AA successively,with the G/A allele frequency of 53 ％/47 ％ (P＜0.05).In the patients with hypertensive renal damage,genotype GG was the most common,followed by GA and AA successively,with the G/A allele frequency of 70％/30％,the genotypes and allele frequency had no statistical difference(P＜0.05).Before and after benazepril treatment,the change range of UAER in the patients with genotype AA was maximal,followed by the genotype GA and GG,the difference among 3 groups was statistically significant(P＜0.05).Conclusion The TNF-α-308 gene is correlated with hypertensive renal damage and its response to benazepril treatment.