Objective] To study six-meridians’exopathy syndromes,to analyze the characteristics of six-meridians’exopathy,and to improve formulas concerned.[Method] Based on ZhangZhongJing’s works,to collect clauses concerned and to improve formulas,which would be compared with each other for analyzing the pathogenesis of six-meridians syndromes. [Result] Wind pathogen is hot ,so that clearing heat with pungent and cool-natured drugs should be used,while exopathy in Yang-meridians‘prognosis is better than Yin-meridians’.The formulas should refer to ZhangZhongJing,YeTianShi and WuJuTong’s works.Exopathy in Tai-yang meridian’s formula is GuiZhi decoction,exopathy in Yang-ming meridian’s formula is MaHuangGancaoXingRen decoction,exopathy in Shao-yang meridian’s formula is XiaoChaiHu decoction,while exopathy in Tai-yin meridian’s formula is GuiZhiRenShen decoction,exopathy in Shao-yin meridian’s formula is MaHuangFuZiXiXin decoction,exopathy in Jue-yin meridian’s formula is MaHuangShengMa decoction.[Conclusion] Formulas were improved,which suite to the pathogenesis of six-meridians’exopathy. Classical formulas and pungent and cool-natured drugs should be compared with each other,which provided an initial foundation to the discussion of hot and cold diseases.