Objective To analyze the security of esomeprazole,amoxicillin and clarithromycin in the treatment of Hp associated gastric ulcer.Methods 96 cases of patients with Hp associated gastric ulcer in our hospital from June 2014 to June 2016 were selected,they were randomly divided into esomeprazole + amoxicillin + clarithromycin treatment group(esomeprazole group,n=48)and omeprazole + amoxicillin + clarithromycin treatment group(omeprazole group,n=48)two groups,the clinical symptom scores,clinical efficacy,Hp eradication and adverse reactions of the two groups were statistically analyzed.Results The abdominal pain,abdominal distension,belching,acid regurgitation scores of theesomeprazole group were significantly lower(P<0.05),the total treatment efficiency 95.8％(46/48)was significantly higher than the omeprazole group 72.9％(35/48)(P<0.05),the eradication rate of Hp 97.9％(47/48)was significantly higher than the omeprazole group 83.3％(40/48)(P<0.05),the adverse reaction rate 2.1％(1/48)was significantly lower than the omeprazole group 8.3％(4/48)(P<0.05).Conclusion The security of esomeprazole,amoxicillin and clarithromycin in the treatment of Hp associated gastric ulcer is higher thanomeprazole,amoxicillin and clarithromycin,so is worthy of promotion in the clinical.