Objective To evaluate the curative effects of the modified fixed reverse Twin-block ap-pliance (TBA)combined Edgewise in the treatment of adult Angle Ⅲ anterior crossbite. Methods The appliance was used in 18 subjects with adult Angle Ⅲ skeletal malocclusion and clinical characters and X-ray cephalometry were then compared before and after treatment. Results The mandibular soft tissue changes could be achieved fast and the profile had changed effectively. Moderate labioclination of maxil-lary anterior teeth played a role in the improvement of axillary soft tissue protrusion. The cases were fol-lowed up as long as 3 years. No relapse occurred in all the patients. Anterior occlusion was normal. Con-clusion All findings indicate that adult Angle Ⅲ anterior crossbite can be quickly corrected with the mod-ified fixed reverse TBA combined Edgewise. The effect on mandibular soft tissue is significant.