To mitigate penumbra injury is the key factor in the treatment ofischemic stroke.Blood reflow and neuroprotection against time are premise to achieve this.Due to time window, thrombolysis rate is low(less than 5% in developed country).However, all neuroprotectants haven't been demonstrated to be effective in human, till now.Based on guidance ofwholism concept ofTCM and analysis ofrelative studies in western medicine.We found that functional status ofnon-ischemic areas can impact on injury degree offocal ischemia.One ofthe reasons that lead to failure in neuroprotective studies may be without considering this impaction.We put forward that non-ischemic areas can impact on the injury degree ofischemic area through the complex neuronal network, and effective regulating the functional status ofnon-ischemic areas is one ofthe key factors which can ameliorate focal ischemic injury.

Poststroke aphasia is an acquired language disorder caused by stroke.It seriously affects the social ability in patients and reduces their quality of life.It might be an unbearable burden on the family and on society.However,the traditional treatment of aphasia has no positive effect.Therefore,pharmacotherapy of aphasia has received much attention.This article reviews the recent progress in researches on pharmacotherapy of poststroke aphasia.

It is important and of heavy workload for the client in C/S system to update.According to the actuality of our hospital,this paper suggests three methods and discusses the suitable conditions respectively.These methods have great value in practice.

Ten factors of the sexual dimorphism on the cranial breadth were analyzed by using the dis- criminant analysis in order to estimate the sex.Results showed that seven out of ten human skulls have sex difference(P

Objective This study aims to examine the development of the posterior lateral line of the zebrafish and establish ant model to study the process of hair cell differentiation and regeneration .Methods We observed the posterior lateral line system formation by DAPI immunohistochemistry and whole mount in situ hybridization .We further evaluated hair cells differentiation within neuromast by using Transgenic Tg (Brn3c:mGFP) zebrafish and stained the functional hair cells by the mechanotransduction marker FM 1 -43FX .We labelled proliferating cells in primordium and neuromast by addition of BrdU to the system water .Results The posterior lateral line primordium originated from a sensory placode and started its journey at around 20 hours post fertilization to migrate along the horizontal myoseptum to the tail -tip with a constant speed (1 .7somite/hour) .The primordium depositd five or six neuromasts spaced along the body ,and two or three terminal neuromasts at the tail -tip at 48 hours post fertiliza-tion .At 3 ,5 and 7 days post fertilization ,zebrafish contained 5 .68 ± 1 .46 ,10 .1 ± 0 .99 ,and 12 .45 ± 1 .32 hair cells per neuromast ,respectively .Furthermore ,the average number of FM1-43FX stained hair cells within each neuro-mast were 3 .68 ± 1 .11 ,8 .18 ± 1 .86 ,and 10 .22 ± 1 .24 ,respectively .Conclusion We establish the development model of hair cells in zebrafish lateral line neuromast and suggest that 3 to 7 days post fertilization is an important period for lateral line neuromast differentiation .This study would be useful for underlying the mechanisms of hair cell differentiation and regeneration .

Three hundred and nine community health service (CHS) practitioners were selected with randomized cluster sampling for survey with the job satisfaction questionnaire-occupational stress indicator (OSI).Degree of the job satisfaction was (68 ± 12)%.Position, work experience, income,feeling of recognition, degree of motivation, the scope for career development, the space for personal ambition and the relationship between salary and work load were potential influencing factors of job satisfaction to CHS practitioners.The authors suggest to establish the dynamic mechanisms of satisfaction study and to formulate comprehensive and effective incentive measures for CHS practitioners.

Objective To observe the efficacy difference between nerve-trunk stimulation plus electroacupuncture at antagonistic points and the control group. Method Patients were randomized into group A (nerve-trunk stimulation plus electroacupuncture at antagonistic points), group B (electroacupuncture at antagonistic points), and group C (basic treatment), 45 cases in each group. The interventions were given once a day, 5 times a week, totally for 4 weeks. The changes of spasm degree and motor function of upper limb and activities of daily life were observed. Result After intervention, there were significant differences between group B and group C, and between group A and group B (P<0.05); there was a significant difference between group A and group C (P<0.01). Conclusion Compared to the control group, nerve-trunk stimulation plus electroacupuncture at antagonistic points can produce more significant efficacies in improving the spasm degree and motor function of upper limb and activities of daily life.

Objective To evaluate the diagnostic yield and the etiological accuracy of double balloon endoscopy and capsule endoscopy in patients with.Methods Seventy-three patients with OGIB received double balloon endoscopy.The route of enteroscopy could be either via mouth or via anus.Negative result of initial route was required afterwards for another via mouth or via anus examination.Sixty-one patients with OGIB received capsule endoscopy.Results The overall diagnostic yield for double balloon enteroscopy was 94.5%,and for capsule endoscopy it was 81.8%.The etiological diagnostic accuracy of double-balloon enteroscopy was 80.8%,and for capsule endoscopy,50.0%.Double-balloon enteroscopy and capsule endoscopy were both well tolerated.Conclusion Double balloon enteroscopy is superior to capsule endoscopy in the diagnostic yield and the etiological diagnosis of obscure gastrointestinal bleeding.

Objective To investigate the effect of the genotypic analysis of donor from cardiac death donation on the initial dose of Tac for liver transplant recipients and provide individualized administration for the early use of Tac in liver transplantation patients.Method Thirty recipients with a different genotype of CYP3A5 from cardiac death donors were collected from March 2010 to February 2013.The matched recipients were randomly divided into experiment group and control group.There was an adjustment of initial doses of Tac according to the donors' different CYP3A5 genotypes in experiment group but not in control group.Result In experiment and control groups,the average Tac blood concentrations at the 7th day after operation were (7.47 ± 1.83) and (8.68 ± 5.14) ng/mL,and the percent of recipeints reaching the optimal Tac concentrations was 72.2％ and 38.9％,respectively (P＜0.05).In experiment and control groups,22.2％ and 55.6％ recipients needed adjustments of Tac concentrations respectively (P＜0.05).Conclusion Individualized adjustment of Tac initial doses of recipients according to cardiac death donors' different CYP3A5 genotypes was benefit for reaching optimal concentrations as soon as possible and could decrease the rate of rejection,and reduce the side effects of Tac.