Primenopausal period syndrome is a kind of usual disease,and people's views differ in disease location,pathogenesis and treatment.We approach the disease from theory to expound that its disease location is Chong Channel and Ren Channel.We find that the imbalance of yin-yang,because of the deficiency in Chong Channnel and Ren Channel,is the source.We apply Chong Channel and Ren Channel,and we also harmonize yin-yang to cure the disease.