This study was aimed to prove the scientific method theory through revealing the effect of synchronous treatment of lung and intestine in the treatment of active ulcerative colitis (AUC) patients. A total of 90 cases with traditional Chinese medicine (TCM) diagnosis of heat-toxin syndrome and western medical diagnosis of AUC were randomly divided into the control group, treatment of intestine group, and synchronous treatment of lung and intestine group, with 30 cases in each group. SASP enema (control group), SASP with Bai-Tou-Weng (BTW) decoction and Tiao-Wei Cheng-Qi (TWCQ) decoction enema (treatment of intestine group), SASP with BTW decoction and Liang-Ge-San (LGS) enema (synchronous treatment of lung and intestine group) were given, respectively. The treatment was given once a day and continued for 60 days. Then, clinical therapeutic evaluation was given before and after the treatment with enteroscopy, Th1/Th2 of ulcerative colon tissues was detected. The results showed that the sequence of clinical effect from top to bottom was synchronous treatment of lung and intestine group, treatment of intestine group, control group, with statistical significance (P< 0.05 or P< 0.01). Comparison of Th1/Th2 before and after treatment among each group showed that Th1 (INF-γ, IL-2) was decreased, Th2 (IL-4, IL-5) was increased (P< 0.05), Th1/Th2 was decreased, with statistical significance (P< 0.01). Comparison among each group after treatment showed that the sequence of Th1 from top to bottom was control group, treatment of intestine group, synchronous treatment of lung and intestine group; that of Th2 was synchronous treatment of lung and intestine group, treatment of intestine group, control group; that of Th1/Th2 was control group, treatment of intestine group, synchronous treatment of lung and in-testine group, with statistical significance (P< 0.01). It was concluded that synchronous treatment of lung and intes-tine had guiding significance on anti-inflammatory effect of enema therapy to AUC.