SHG was sulfated by chlorosulfonic acid-pyridine method, and six samples which we got were prepared in different reaction conditions. There is a characteristic absorption peak near 260 nm in UV spectra and there are two characteristic absorption peaks near 1240 cm(-1) and 810 cm(-1) in the FT-IR. Degree of sulfation (DS) was calculated by elemental analysis and turbidimetry. Under the same conditions the absorption peaks become strong with the DS increase. The anticoagulant activity of SHG and sulfated modification samples was evaluated by the classic coagulant assays of prothrombin time (PT), activated partial thrombin time (APTT) live enzymes, and plasma thrombin time (TT). Results show that sulfated SHG has a good anticoagulant activity in vitro, and DS increased activity within a certain range.

There are many disadvantages in the traditional teaching of pharmacology experiment, so it is difficult to assess students' experimental skills and comprehensive levels. Based on the comprehen-siveness, fairness, objectivity and reciprocity, we put forward a test-system which contains experimental preparation oral, experimental skills, experimental records, experimental reports, design experiments, ordi-nary performance and final experiment theory exam, hoping to provide a reference for the establishment of a new pharmacology experiment course assessment system.

Objective To observe the clinical efficacy on the treatment of diabetic gastroparesis of self-designed Xiaopi Formula. Methods Totally 200 cases of DGP were divided into the observation group and the control group with random number table, with 100 cases in each group. Two groups were given the general treatment scheme, such as the subcutaneous injections of insulin or oral hypoglycemic medicine. The patients in the control group were treated with Domperidone orally, one tablet each time, 3 times a day;while the patients in the observation group were treated with self-designed Xiaopi Formula, twice a day, one time for morning and one time for evening. One course lasted for one month, 3 courses in total. Clinical efficacy and the change of gastric emptying rate, glycosylated hemoglobin and hemorrheology in the two groups were observed. Results Total effective rate of observation group (94.0%) was higher than that of the control group (82.0%), with statistical significance (P<0.05). After treatment, blood sugar decreased and gastric emptying rate improved in both groups (P<0.05), and observation group was superior to control group (P<0.05); The control group in terms of improving hemorrheology had no obvious significance (P>0.05); Observation group can obviously improve the indexes of blood rheology, with statistical significance with control group (P<0.05). Conclusion The clinical efficacy of self-designed Xiaopi Formula for the treatment of diabetic gastroparesis is obvious, which can promote gastric emptying rate and decrease HbA1c level, and improve blood rheology.