AIM: To study immunosuppressive effects of Tongbizhitong Capsule. To reveal the anti-inflammatory mechanism of this capsule. METHODS : The anti-inflammatory effect was determined with the adjuvant arthritis models of the rats with adjuvant arthris (AA) paw edema. We also observed the blood oxygen free radican,nitric oxide(NO) with AA. The immunosuppressive effect was determined with T-cell subsets in spleen of rats with AA,serum haemolysin level of mouse,the delayed type hypersensitivity. RESULTS : Tongbizhitong Capsule had remarkable inhibitory effect on carrageenine induced granulation and on the prevention of AA. In the T-cell subsets: low,middle and high dose decreased T_h and high dose inhibited both T_s and T_h preacted mainly on T_h and rendered the decreased ratio of T_h/T_s. The delayed type hypersensitivity reaction was distinctly suppressed. It also had a suppressive action on serum haemolsin. Only the high dose could decrease serum lipid deroxides and NO contents,and increase superoxide dismutase and glutathione peroxidase levels. CONCLUSION : Tongbizhitong Capsule has suppressive effect on immune function.

Objective To evaluate the clinical diagnostic value of prospective electrocardiograph (ECG)-gating of CT cardiac angiography in congenital heart diseases of Chinese population through a Meta-analysis.Methods The articles were searched to study CT prospective ECG-gating in diagnosis of congenital heart disease from January 1995 to February 2016 in domestic and foreign publications.The study quality was assessed by the Quality Assessment for Diagnostic Accuracy Studies and the data extraction was performed.The software of Meta-disc1.4 was used for heterogeneity test.Different effect models were choosen according to the results of heterogeneity analysis.Meanwhile,this soft was used to calculate the sensitivity,specificity,likelihood ratio and its 95％ confidence interval (CI),respectively.The forest maps and summary receiver operator characteristic (SROC) curve were drawn.In addition,the area under curve (AUC) was calculated.Results Twelve articles were included in the Meta-analysis.The study included 1 431 congenital heart malformations confirmed by surgery or cardiac catheterization angiography.CT prospective ECG-gating technique had no heterogeneity in sensitivity and specificity of congenital heart disease.The total sensitivity,the total specificity,positive likelihood ratios,negative likelihood ratios and its 95％ CI of CT cardiac angiography were 96％ (95％ CI 94％ to 97％),100％ (95％ CI 100％ to 100％),365.94(95％ CI 231.18 to 579.26),0.04(95％ CI 0.03 to 0.05) with fixed effect model,respectively.The AUC of the SROC was 99.86％,Q =0.987 9.Conclusions Prospectively ECG-gating of CT cardiac angiography has high sensitivity and specificity in the diagnosis of congenital heart diseases.Its AUC of the SROC is large.It has high diagnostic value in congenital heart diseases.