1.Inhibition of resveratral on lipid peroxidative reaction and reactive oxygen species of early experimental rat spinal cord injury
Chinese Journal of Clinical Pharmacology and Therapeutics 2000;0(03):-
AIM: To study the effects of resveratral on lipid peroxidative reaction and reactive oxygen species (ROS) in experimental spinal cord injury rats. METHODS: The weight dropping method was used to produce the experimental spinal cord injury (SCI) in adult rats. Resveratrol (Res) and methylprednisolone (MPSS) were given intraperitoneally by the bolus injections of 50, 100 mg?kg -1 and 100 mg?kg -1 , respectively, immediately after induction of SCI. And then the effects of Res were observed at 1, 24, 48 h after SCI compared with MPSS. RESULTS: Res could obvious prevented reduction of superoxide dismutase (SOD) activity and reduce malondialdehyde (MDA) production and inhibit the ROS level in the injured spinal cord tissue in comparison with the SCI model at the dose of 50 mg?kg -1 and 100 mg?kg -1 , which the most remarkable effects was at 48 h with the inhibition rate over 40%. The effects of Res were the same as or even greater than those of MPSS. CONCLUSION: Res may effectively protect the spinal cord from lipid peroxidative reaction and ROS damage in SCI.
2.Effects of resveratrol on secondary spinal cord edema and activity of lactic dehydrogenase and ATPase in experimental spinal cord injury of rats
Chinese Pharmacological Bulletin 1986;0(05):-
AIM To study the effects of resveratrol on secondary spinal cord edema and the activity of lactic dehydrogenase and Na +, K + ATPase in experimental spinal cord injury (SCI)rat. METHODS The weight dropping method was used to produce the experimental spinal cord injury in adult rats. Resveratrol (Res) and methylprednisolone (MPSS) were intraperitoneally by the bolus injections of 50 mg?kg -1 , 100 mg?kg -1 and 100 mg?kg -1 , respectively, immediately after the induction of SCI. And then the effects of Res were observed at 1 h, 24 h, 48 h after SCI compared with MPSS. RESULTS Res could obvious inhibit the secondary spinal cord edema with the most remarkable suppressing rate by 11 5% at 48 h. Res was able to significantly suppress the activities of the lactic dehydrogenase with the highest suppressing rate for over 40% at 24 h. In the meantime, Res markedly improved the Na +, K + ATPase activities that promoted to the biggest extent to 60% at 48 h. The effects of Res were the same as or even stronger than those of MPSS. CONCLUSION Res may effectively protect the spinal cord from secondary spinal cord edema and improve the energy metabolism system in SCI. It suggested that Res may be having potent therapeutic effect on SCI.
3.Study of relationship between pathological types of thrombus and changes of ST segment in patients with acute myocardial infarction
The Journal of Practical Medicine 2015;(20):3311-3313
Objective To investigate the relationship between pathological types of intracoronary thrombus and changes of ST segment in patients with acute myocardial infarction. Methods Thrombus aspiration during primary PCI was performed in 65 ST-elevation myocardial infarction (STEMI) patients and 42 non-ST-elevation myocardial infarction (NSTEMI) patients. Pathological analysis on thrombosis was made. Results Thrombi characteristics were collected from 48 STEMI patients and 12 NSTEMI patients. In the STEMI group, 39(81.3%) red/mixed thrombus and 9(18.7%) white thrombus were found. While in the NSTEMI group, 8(66.7%) white thrombus and 4(33.3%) red/mixed thrombus were obtained. Conclusions There are both red/mixed and white thrombus in the two kinds of acute myocardial infarction. A variety of elements, including thrombus formation, could contributes to the change of ST in electrocardiograph during acute myocardial infarction.
4.Research progress of the role of thrombin activatiable fibrinolysis inhibitor in cardiovascular and cerebrovascular diseases
Basic & Clinical Medicine 2017;37(2):261-264
Thrombin activated fibrinolysis inhibitor ( TAFI) is a kind of plasma enzymes that can be activated by thrombin.TAFI regulates blood coagulation and fibrinolysis and has a strong fibrinolytic and anti-inflammatory ac-tivity.Its inhibitor is expected to minimize the risk of bleeding when thrombolytic recanalization .Also, studies found that TAFI played an important role in the development of cerebral thrombosis;atherosclerosis and so on .
5.Typing,Precaution and Treatment of the Bone Cement Leakage Caused by Percutaneous Vertebroplasty
Yingjie LIU ; Yan DONG ; Weiguang YANG
Journal of Chinese Physician 2001;0(10):-
Objective To explore the typing,precaution and treatment of the bone cement leakage caused by percutaneous vertebroplasty(PVP).Methods PVP was performed in 38 cases(11 men and 27 women) with vertebral angioma and vertebral body compression fracture with osteoporosis chosen from November 2002.Results All the patients were followed up for 8 to 16 months and the effects were evaluated by the standards carried out by World Health Organization(WHO).The rate of complete response(CR) plus partial response(PR) was 100 percent.The patients with bone cement leakage by PVP were divided into 3 groups which underwent different remedial methods respectively.Conclusion The bone cement leakage could be prevented through the preoperative preparation,choosing the anaesthesia and scouting the whole operation.The patients with TypeⅠ,Ⅱ and Ⅲ_a needn't treatment,but those with type Ⅲ_b must accept open-operation.Vertebral eggshell technology with open vertebroplasty was effective on the treatment of the bone cement leakage with type Ⅲ_b caused by PVP.
6.Surgical Methods of Esophageal Carcinoma Complicated With Cicatricial Pyloric Obstruction
Jigang HU ; Yingjie CHEN ; Xiaogang YANG
Journal of Chinese Physician 2001;0(02):-
Objective To search the surgical methods of esophageal carcinoma complicated with cicatricial pyloric obstruction .Methods 18 cases were treated with resection. Among the resections,16 cases underwent resection of esophageal carcinoma esophago-gastrostomy above aortic arch in chest plus gastro-jejunum anastomosis ;2 cases treatment with resection of esophageal carcinoma plus esophago-gastretomy above aortic arch in chest combined with pyloroplasty.Results Of 18 cases ,cure rate was 100%.No severe complications were occurred in the procedure. Conclusion Surgical operation is safe , applicable and effective in treatment of esophageal carcinoma complicated with cicatricial pyloric obstruction.
7.An animal model of obstructive sleep apnea syndrome.
Lei YANG ; Yingjie HU ; Xiaowen ZHANG
Journal of Clinical Otorhinolaryngology Head and Neck Surgery 2012;26(12):569-572
Obstructive sleep apnea syndrome (OSAS) is endangering human health seriously now. We had reviewed some typical animal model which had at least one OSAS character of intermittent hypoxia and/or hypercapnia, upper airway obstruction and sleep structure disorder. However, all of these models could not simulate clinical and pathological features of OSAS completely. Establishing a suitable animal model to study OSAS and related diseases is very important.
Airway Obstruction
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etiology
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Animals
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Disease Models, Animal
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Humans
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Hypercapnia
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etiology
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Hypoxia
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etiology
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Sleep Apnea, Obstructive
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complications
8.Discussion on personnel capacitye valuation of quality control laboratory staff in blood banks
Yingjie QIU ; Jianhao YANG ; Zhong XU
Chinese Journal of Blood Transfusion 2017;30(7):849-851
Objective To carry out regularpersonnel capacity evaluation of quality control laboratory (QC Lab) staff,combinedwith the actual situation of the QC Lab and the requirement of national capacity assessment.Method Establish an evaluation program,including assessment items,frequency,eligibility criteria,etc,to effectively implement the program.Results Two evaluations were conducted for nine staff membersin the lab from 2015 to 2016.The pass rate of the four test items and operation of the instrumentwere 100%.The ability to solve the problem was variable among the staff.Conclusion According to the evaluation results,staff classification management and training will effectively promote the improvement of personnel capacity and ensure the quality of laboratory testing.
9.Effect of Ligustrazine on the Expression of Connective Tissue Growth Factor and Osteopontin in the Tubulointerstitium of Diabetic Nephropathy Rats
Yan YANG ; Chunguang XIE ; Yingjie DU
Traditional Chinese Drug Research & Clinical Pharmacology 1993;0(02):-
Objective To observe the effect of ligustrazine (TMP) on the expression of connective tissue growth factor (CTGF) and osteopontin (OPN) in the renal tubulointerstitium of diabetic nephropathy (DN) rats. Methods Wistar rats were used to establish the models through intraperitoneal injection of onedose streptozotocin (STZ) and nephrectomy. Rats were divided into 5 groups at random: model group, blank control group, Lotensin (1.7 mg? kg- 1? d- 1) group, of high-and lowdosage of TMP groups (150, 50 mg? kg- 1? d- 1). Except the rats in blank group and model group, the rats received corresponding medicines according to the experimental design for 12 weeks.Volume of urine protein within 24 hours was examined in the 4th, the 8th and the 12 th week, OPN mRNA expression in the renal tubulointerstitium was detected by RT- PCR and CTGF was detected by means of immunohistochemistry. Results Compared with normal group, the volume of 24 h urine protein rised obviously (P
10.Investigation on Bacterial Contamination of Office Telephones and Computers in an Infectious Disease Hospital
Keping LI ; Jing YANG ; Yingjie ZHUANG
Chinese Journal of Nosocomiology 2009;0(21):-
OBJECTIVE To investigate the bacterial contamination of office telephones and computers in an infectious disease hospital to provide evidence for their disinfection.METHODS A total of 206 bacterial samples were collected from 73 telephones and 30 computers in offices in our hospital to determine the bacterial contamination of these office tools.RESULTS The contamination rate was 100% and sanitary qualification rate 32.5%.The highest bacterial colony count was 46 CFU/cm2 and the lowest one 2 CFU/cm2,The sanitary qulification rate of the telephones and computers in clean region was only 30.95%.CONCLUSIONS There was severe bacterial contamination in office telephones and computers,which should be paid close attention to.