1.Supportive Care Needs of Breast Cancer Patients (review)
Yingjie CAI ; Tieying SHI ; Yanjiao LI
Chinese Journal of Rehabilitation Theory and Practice 2016;22(7):813-817
Breast cancer is the most common cancer among females. During the time of treatment and rehabilitation, the patients and their relatives need to help them to prevent, control or relieve all sorts of complications and adverse events that beyond their medical, surgi-cal or radiation interventions, called Supportive Care Need. There are many tools to evaluate these needs, such as Supportive Care Need Sur-vey, Cancer Patients Needs Questionnaire, etc., and mainly involved the needs of health system, information, patient support, psychology, physical and daily living, and sexuality, varied with the factors of social demography, disease and treatment, and psychology;and the inter-ventions contain cognitive behavior and psychology.
2.Correlation between professional commitment and academic self-efficiency of nursing undergraduates
Yingjie CAI ; Tieying SHI ; Yanjiao LI
Modern Clinical Nursing 2016;15(11):65-68
Objective To investigate the correlation between professional commitment and academic self-efficiency of nursing undergraduates.Method A total of 258 students were investigated by nursing professional commitment questionnaire and academic self-efficiency scale.Results The score of professional commitment was (89.05±14.92) and the academic self-efficiency was scored (73.78±10.38).The professional commitment was positively correlated with academic self-efficiency (P<0.01).Conclusions There are close relationships between professional commitment and academic self-efficiency for nursing undergraduates.The nursing educator should take effective measures to improve nursing students' professional commitment and academic self-efficiency.
3.Research progress of Health promoting lifestyle and intervention measures in patients with chronic diseases
Shengnan CAO ; Yu LIU ; Yingjie CAI ; Tieying SHI ; Genya SHI
Chinese Journal of Practical Nursing 2021;37(15):1185-1191
Health promoting lifestyle can help patients with chronic diseases to prevent diseases, maintain their health, and reduce or eliminate dangerous behaviors by changing the incorrect lifestyle of chronic diseases. This article reviews the overview, measuring tool, status quo, influencing factors, and interventions of health promotion lifestyle for patients with chronic diseases, and puts forward the corresponding prospects.
4.A longitudinal study of nursing undergraduates′ humanistic care ability in different stages of clinical practice
Yingjie CAI ; Chunli SONG ; Tieying SHI ; Yanjiao LI
Chinese Journal of Practical Nursing 2017;33(24):1882-1885
Objective To do a longitudinal study of nursing undergraduates′ humanistic care ability in different period of clinical practice, and analyze its trend, aiming to provide reference about how to intervene to enhance the nursing undergraduates' humanistic care ability. Methods A total of 67 nursing undergraduates were investigated about their humanistic care ability with the Care Ability Inventory (Caring Ability Inventory, CAI) at the beginning, middle and end of the internship. Results The scores of seniors′ humanistic care ability at the beginning, middle and end of the internship were 194.97±22.93, 192.18±26.87, 187.24±22.15, and there was a statistically significant difference among the three time points (F=3.234, P<0.05), there was significant difference of the dimension of courage in different periods (F=7.511, P<0.01). Conclusions There is a downtrend of nursing undergraduates′humanistic care ability in different stages of clinical practice, and we suggest that nursing educators and administrators should consider the characteristics of different periods in the clinical practice, and then do a targeted training to foster nursing students′humanistic care ability.
5.The present situation of dysfunctional uterine bleeding treated with Anchong Decoction
Huijun XU ; Yingjie ZHANG ; Xuemeng RAN ; Hui XUE ; Wei SHI
International Journal of Traditional Chinese Medicine 2010;32(2):178-179
The paper reviewed clinical reports on the treatment of hypermenorrhea, menostaxis, and uterine bleeding with Ancong Decoction and modified Ancong Decoction. Although there were few reports concerned with clinical usage, Ancong Decoction has sound therapeutic effects, with more than 90% effective rate.
6.Risk factors of upper gastrointestinal injury induced by non-steroidal anti-inflammatory drugs
Guoyong RUAN ; Yingjie JIANG ; Wei SHI ; Aixia LIANG ; Shuguang LI
Chinese Journal of Postgraduates of Medicine 2013;(7):37-40
Objective To investigate the risk factors of upper gastrointestinal injury induced by non-steroidal anti-inflammatory drugs (NSAIDs).Methods A total of 1032 patients which used NSAIDs was selected.Patients were divided into two groups based on the condition of dyspepsia,peptic ulcer or upper gastrointestinal bleeding:the adverse drug reaction group (331 cases) and the control group (701 cases).Data of two groups on clinical presentation,laboratory test,medication and treatment were analyzed.Risk factors for the adverse drug reaction were identified by multivariable Logistic regression.Results The two groups had significant difference in age > 65 years old,Helicobacter pylori (Hp) infection,ulcer history,drug overdose,combination with glucocorticoid,addicted to tobacco and alcohol history,non-specific inhibitor of cyclooxygenase(COX)-2,combination with anticoagulant,concomitant chronic cardiopulmonary disease (P < 0.05).Logistic regression analysis by backward elimination method revealed that following variables retained,such as combination with glucocorticoid (OR =3.104,95% CI 1.936-4.695),Hp infection (OR =2.768,95% CI 2.047-3.742),drug overdose (OR =2.411,95% CI 1.683-3.453),ulcer history (OR =1.781,95% CI 1.278-2.480),age > 65 years old (OR =1.659,95% CI 1.237-2.225),non-specific inhibitor of COX-2 (OR =1.470,95% CI 1.103-2.133),addicted to tobacco and alcohol history (OR =1.459,95% CI 1.032-2.064),concomitant chronic cardiopulmonary disease (OR =1.357,95% CI 1.008-2.143),P<0.05.Conclusion Combination with glucocorticoid,Hp infection,drug overdose,ulcer history,age > 65 years old,non-specific inhibitor of COX-2,addicted to tobacco and alcohol history,concomitant chronic cardiopulmonary disease are risk factors of upper gastrointestinal injury induced bv NSAIDs.
7.The Effect of Lactate on the Contractile Force of Ventricular Papillary Muscle and Cellular Action Potential
Zhaoqiang LIU ; Yingjie LIU ; Jitian ZHU ; Qingzhao SHI
Chinese Journal of Tissue Engineering Research 2001;5(7):155-156
Objective To study the effect of lactate of differentconcentration on the action potential of ventricular papillary muscle cell (n=4) and contractile force (n=10).Method Using intracellular microelectrode technique and microtension depicting method.Result The Result showed the effect of lactated solution of a certain comcentration became obvious. After perfused with lactate solution of 4mmol/L,the vilocity maximum decreased significantly (p<0.05) showed the 4mmol/L lactate solution decreased the rate of depolarization: decreased the efficency of Na + channel; lactate solution decreased the contractile force of cardiac muscle. Conclusion The possible mechanism was: Ca+ influx and Na+ - H+ exchange were inhibited, resulted in the elevation of intracellular H+ concentration; through Na+-Ca2+ exchange, Ca2+ efflux decreased resulted in the intracellular Ca2+ decreased resulted in the intracellular Ca2+ overload.
8.Pharmacodynamic experiment of the antivirus effect of houttuynia cordata injection on influenza virus in mice.
Fangzhou LIU ; Han SHI ; Yujing SHI ; Ying LIU ; Yahong JIN ; Yingjie GAO ; Shanshan GUO ; Xiaolan CUI
Acta Pharmaceutica Sinica 2010;45(3):399-402
It is to investigate the effect of two kinds of Houttuynia Cordata Injection on preventing and treating H1N1 influenza virus infection in mice. Pneumonia model was set up by intranasal infection of the normal and immunocompromised mice with influenza virus FM1 and PR8. The two injections were administered before and after the administration of virus, separately, and the lung index was observed. The results showed that the two preparations have obvious therapeutic effect on normal mice infected with influenza virus FM1 and PR8. And to FM1, the new injection's effect is better at small dosage. The results also showed that the two preparations have obvious prophylactic effect on immunodepressed mice infected with influenza virus FM1 and PR8. And to PR8, the old injection's effect is better at small dosage. Houttuynia Cordata Injection can improve the mice pneumonia caused by influenza virus H1N1 and decrease the lung index markedly. It has a remarkable preventive and therapeutic effect on H1N1 influenza virus in mice.
9.CT appearances of abdominal primary malignant fibrous histiocytoma
Peihong QI ; Dapeng SHI ; Hongwei ZHENG ; Yingjie SHANG ; Peng XUE ; Yong CHEN
Journal of Practical Radiology 2016;32(7):1056-1058,1062
Objective To investigate CT appearances of abdominal primary malignant fibrous histiocytoma(MFH).Methods The CT characteristics,clinical features and pathological data of 1 7 patients with MFH proved pathologically were analyzed retrospectively. Results The lesions located in retroperitoneum were 6,in liver were 5,in kidney were 2,in superior mesentery was 1,in greater omentum was 1,in stomach was 1,in ileum was 1.The lesions are oval shape,lobulated,nodule shape,and the size of these lesions were large. 2 cases of MFH located in gastrointestinal tract were slightly low density,and the remaining were uneven high density due to necro-sis.In CT contrast enhanced scan,the solid portion and internal divisions showed progressive or continuous enhancement,and the nec-rosis were not enhanced in MFH located in the retroperitoneum,the greater omentum,the superior mesentery and the liver.MFH in kidney was poorly circumscribed and showed mild progressive enhancement lower than normal renal parenchyma.The stomach and ileum lesions showed uniform and continuous enhancement with normal gastrointestinal mucosa in corresponding parts.Conclusion Imaging features of retroperitoneal MFH were the same as those of interstitial tumors,and most tumors showed features of progres-sive and persistent enhancement,but have different imaging appearances with the malignant lesions in corresponding parts.
10.Copper, iron, zinc-fluorouracil complexes synthesized in vitro inhibit tumor cell proliferation
Yiping ZHOU ; Yuanxiao CHEN ; Yun ZHOU ; Zhongzheng SHI ; Min LUO ; Wenyuan ZHONG ; Yingjie CHEN
Chinese Journal of Tissue Engineering Research 2014;(39):6309-6315
BACKGROUND:Anticancer drug and organic metal complexes wil form a new structure or a change in ion concentration, thus changing both the activity and toxicity to produce a synergistic effect. OBJECTIVE:To synthesize new high-efficient and low-toxic metal-fluorouracil complexes as anticancer drugs. METHODS:Copper, zinc and iron salts and fluorouracil were used to synthesize four copper, zinc and iron-fluorouracil complexes that were [Cu(5-Fu)2Cl2], [Cu(5-Fu)2(NO3)2], [Fe(5-Fu)3]SO4 and [Zn(5-Fu)2Cl2]. Preliminary chemical structures of the four complexes were confirmed by elemental analysis and mass spectrometry. Their inhibitory activity on human cancer cells, human leukemia cellline K562 and human colon cancer cellline HCT-116, was measured by MTT colorimetric assay. RESULTS AND CONCLUSION:[Cu(5-Fu)2Cl2], [Cu(5-Fu)2(NO3)2], [Zn(5-Fu)2Cl2] and [Fe(5-Fu)3SO4] were successful y synthesized. These four complexes at a mass concentration of 0.1-100 mg/L inhibited the proliferation of K562 and HCT-116 to different extents. The IC 50 values of these four complexes on K562 and HCT-116 cells were lower than those of fluorouracil, and their cytotoxicity was 1.5-7.8 times higher than that of fluorouracil. To conclude, copper/iron/zinc-fluorouracil complexes exhibit synergic inhibitory effects on cancer cellproliferation.