1.Progress of cellular growth factors in neurorehabilitation and neuroplasticity
Xiaokun LI ; Xu LIU ; Jiahua LIU ; Zhiheng RAO ; Yingde LUO ; Keyang CHEN ; Tong ZHANG
Chinese Journal of Rehabilitation Theory and Practice 2022;28(2):175-182
With potent biological activities, cellular growth factors are polypeptide factors that primarily stimulate cell growth and proliferation. They participate in the regulation of not only normal physiological functions such as human embryonic development and cell growth, but also neurorehabilitation and neuroplasticity in pathological processes such as nerve injury and recovery. Specifically, cellular growth factors have been shown to promote neuron survival, facilitate nerve regeneration and regulate synaptic plasticity, promote cell differentiation/vascular regeneration and modulate the microenvironment, promote nerve fiber myelination and improve nerve conduction. This review summarized current knowledge on the roles and various growth factors in neurorehabilitation and neuroplasticity, providing an update on potential clinical application of cellular growth factors in the field of neural rehabilitation.
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