Objective To observe absorption of exogenous nerve growth factor(NGF) between normal newborn rats and newborn rats with hypoxidosis.Methods Thirty-two healthy newborn rats(7 days of age) were divided into experiment group and normal group.Experiment rats were made into hypoxic-ischemic brain damage(HIBD) model.NGF labeled with()~(125)I or()~(125)I was injected into the rats abdominant.All of the rats were killed and brain was removed after 30 minutes.The brain was dissected into basal forebrain,forehead cortex,hippocampus,thalamus,cerebellum,smellorb,pituitary tissue samples were assayed for radioactivity in a two-channel gamma counter.Results Absorptions of two groups(()~(125)I-NGF) were significantly higher than those of()~(125)I in basal forebrain,cortex,hippocampus,cerebellum.Absorptions of hypoxic group were significantly higher than those of control group in cortex,hippocampus,cerebellum.Conclusions NGF can penertrate blood brain barrier of newborn rats into brain regions by means of peripheral administration.Early application of NGF for treating hypoxic-ischemic encephalopathy(HIE) is feasible.

Objective To evaluate the efficacy and prognostic factors in patients with liver metastases from colorectal carcinoma treated by interventional therapy.Methods Follow up information of 80 patients with liver metastases from colorectal carcinoma were analyzed. The survival time and parameters were likely to affect the prognosis revealed by statistical methods. Results It was shown that the over all 0.5,1,2,3year survival rates were 100%,75.8%, 31.5% and 10.8% respectively. Univariate analysis showed that the age, the volume ratio of the tumors/liver, abundance of the tumor vessels, the retention of the lipiodol, resection of the original lesion and the difference of the tumor sizes between pre therapy and post therapy were the significant prognostic factors. Multivariate analysis showed that abundance of the tumor vessels and the difference of the tumor sizes between pre therapy and post therapy were the most significant factors. Conclusions The hepatic arterial infusion chemotherapy and embolization are effective to patients with liver metastases from colorectal carcinoma proportionately to the tumor vascular abundance and primary lesion resection.

OBJECTIVE:To study the drug price administration models in some developed countries,so as to provide ref?erence information for establishing drug price administration model in China.METHODS:The comparative method and crite?rion method were adopted to study the published literature.RESULTS&CONCLUSION:Although different countries have carried out different models,they still have similarity in some policies.Therefore,we should pay attention to learn the advan?tages in different drug administration models.

This article try to illustrate the relationship of self value and personality by paraphrasing these two concepts,and deduce the effects of self value to personality from this.This article also point out the questions how to direct and help university students to set proper self value and then modle healthy personality.It bring forward supposition of the resolvement of the questions.On the base of the demonstrative research we carry out a validative research.

Objective To summarize the experience of nursing cooperation in endoscopic sinus surgery for low temperature plasma radiofrequency ablation of skull base tumor, and to explore the safety and feasibility of this technique. Methods A total of 69 patients with skull base tumor were treated with low temperature plasma radio frequency technology to remove skull base tumor. Results Totally 62 cases of skull base tumors completed total resection in low temperature plasma radiofrequency ablation, 7 cases gained subtotal resection. The operation demonstrated superior advantage of less bleeding, short operation time, less postoperative pain and no adverse events. Conclusions The skull base tumor resection for patients with skull base tumors with low-temperature plasma radiofrequency possesses the advantages of short operation time, less bleeding and thermal damage to the surrounding tissues, besides it can reduce the postoperative discomfort, shorten hospitalization time and reduce the occurrence of nursing adverse events.

Newborn due to low birth weight caused by preterm or fetal growth restriction will have an adverse effect on kidney development. In adulthood,the long-term adverse effects of low birth weight are associ-ated with a variety of kidney disease. Current studies suggest that low birth weight may participate in a variety of kidney disease development and progression by affecting the nephron number,the function of the vascular struc-ture and the endocrine level. This paper mainly reviews the relationship between low birth weight and kidney dis-ease.

Objective To analyze the diagnose and treatment of drug-induced hypersensitivity syndrome (DIHS) in children.MethodsThe clinical data from one case of highly suspected DIHS were retrospectively analyzed. The related literatures were reviewed.ResultsA 22-month-old male child with severe pneumonia, after treated with vancomycin, suffered with high fever and skin rash combined with hepatic lesion and hematological system disorder. After withdrawal of vancomycin and then treatment with the combination of high-dose methylprednisolone and intravenous immunoglobulin, the clinical symptoms were gradually relieved in 24 hours. The child was improved and discharged on 17th day.ConclusionThe child has the characteristics of DIHS which is highly suspected to be caused by vancomycin.

Microglia(MG)is recognized as the main immune effector in central nervous system injury and disease.MG can regulate the tumorigenesis and development of brain metastases tumor(BMT)by different ways.Studing the roles and mechanisms of MG in BMT will provide new insights into the prevention and treatment of BMT.

Objective To evaluate the teaching quality of AIDS and drug abuse and to provide evidences for teaching improvement.Methods Quantitative research and qualitative research was combined.Questionnaire including evaluation of curriculum,teachers and teaching quality was conducted among 273 students majored in anesthesiology and clinical medicine (2006 grade) as well as in forensic medicine,laboratory and stomatology (2008 grade) in quantitative research.Observation and indepth interview were used in qualitative research to observe the teaching process and receive students'feedback.Information about students' evaluation criterions and attitude toward teachers were collected by qualitative research.Chi-square test and descriptive statistic were used with SPSS 13.0.Results 90.8％ students thought this lesson was necessary and important and the contents were accepted by them.24.2％ students expected increasing study hours and having practice classes.Evaluation of course time,contents and importance were different by students of different majors.Average scores of students' evaluation on teachers' quality,teaching contents and teaching methods were 25.2,22.4,11.0,respectively.Three aspects of teaching methods got the lowest scores:vivid (2.71 points out of 3.0 points),interaction (2.71 points out of 3.0 points) and flexibility (2.72 out of 3.0 points).Interview results demonstrated that students have diversified demand for teaching methods and expect to increase practice lessons and multimedia teaching as well as to effective communicate between teaching and learning.Conclusions Course of AIDS and drug abuse is accepted by students.As a whole,students are basically satisfied with teachers,however,teachers and related sectors should pay more attention to teaching method improvement and teaching skill enhancement.

Recently,paclitaxel has been used as a new agent on patients with advanced esophageal cancer,and several studies have demonstrated that paclitaxel and paclitaxel-based regimens have significant activity in patients with advanced esophageal cancer and showed highly response rates than the combination of 5-fluorouracil (5-Fu) and cisplatin.However,there have been some problems which need to be solved such as drug-resistance,side effect,and so forth.The new medicament form of paclitaxel can not only depress poison without anti-allergy but also raise medicament curative effect as well as the pharmacal concentration.Although most of the research on the new medicament form of paclitaxel are still limited in the stage of laboratory,it has possessed potential advance in the treatment of advanced esophageal cancer.