ObjectiveTo understand the influenza vaccination rate and influencing factors of children aged 6 months to 5 years in Shunyi District,Beijing in June from 2016 to 2021,and analyze the surveillance status of suspected adverse events following immunization(AEFI)after vaccination.MethodsThe data of influenza vaccination and AEFI report of children,influenza vaccination status and follow-up observation of children with underlying diseases after the trial implementation of“Vaccination Recommendations”in Shunyi District of Beijing from 2016 to 2021 were collected to analyze the coverage rate and AEFI report.ResultsFrom 2016 to 2021,a total of 11 996 children aged 6 months to 5 years were vaccinated with influenza vaccine in Shunyi District of Beijing,and the vaccination rate increased year by year(χ2=11 921. 129,P < 0. 01；χ2=11 921. 129,P < 0. 01；χ2_(trend)= 8 881. 396,P < 0. 01);With age,the influenza vaccination rate showed a rising trend(χ2_(trend)= 8 881. 396,P < 0. 01);With age,the influenza vaccination rate showed a rising trend(χ2= 4 073. 395,P < 0. 01；χ2= 4 073. 395,P < 0. 01；χ2_(trend)= 3 495. 611,P < 0. 01);The vaccination rate of children in urban areas was higher than that in rural areas(χ2_(trend)= 3 495. 611,P < 0. 01);The vaccination rate of children in urban areas was higher than that in rural areas(χ2= 497. 153,P < 0. 01). 9 children with underlying diseases who met the “Proposal of Vaccination Experts” were followed up and no adverse reaction was observed after being vaccinated with influenza vaccine.Conclusion In Shunyi District of Beijing,the influenza vaccination rate for children aged 6 months to 5 years was relatively low,and no adverse reactions different from other vaccines have been detected. It was safe and reliable to vaccinate children suffering from basic diseases under the guidance of“Vaccination Recommendations”.

Objective To study the potential improvement of donor heart storage by A1 adenosine receptor-induced delayed preconditioning and its relation with NF-?B. Methods A total of 64 male Wistar rats were randomly divided into 6 groups. Group A was pretreated with 2-chloro-N6-cyclopen-tyladenosine (CCPA), and Group B was only injected saline. Twenty-four hours later, the hearts in groups A and B were stored in St.Thomas solution for 4 h at 4 ℃ and reperfused with K-H buffer for 1 h. Group C was administered with CCPA after 15-minute saline injection, and Group D was injected with inhibitor of nuclear factor ?B, pyrrolidindiethyldithiocarbamate (PDTC) first and 15 min later injected with CCPA. Group E was only injected with saline and Group F with PDTC. Twenty-four hours later, the rat hearts were isolated, perfused with H-K buffer solution on the Langendorff apparatus, and subjected to hypothermic ischemia for 180 min with intermittent perfusion of modified St. Thomas solution, and reperfused with 37 ℃ H-K buffer for 60 min. Left ventricular function, myocardial CK-MB leakage, tissue levels of adenosine triphosphate were measured. Results The recovery rate of ?dp/dt max left ventricle in Group A were much higher than that of Group B, while that in Group C were much higher than that in groups D, E and F (P

OBJECTIVETo observe the clinical efficacy difference in the treatment of neonatal hypoxic ischemic encephalopathy (NHIE) between the combined therapy of acupuncture land acupoint injection of nerve growth fac-tor (NGF) and the combined therapy of the intravenous drop of citicoline sodium and intramuscular injection of NGF.

METHODSSixty-one cases of NHIE were randomized into an observation group (32 cases) and a control group (29 cases). In the observation group, acupuncture combined with acupint injection of NGF was adopted. The acupoints were Baihui (GV 20), Dazhui (GV 14) and Fengfu (GV 16), 0. 5 mL each acupoint, once a day. In the control group, the intravenous drop of citicoline sodium and intramuscular injection of NGF were used. The, treatment of 7 days made one session and 3 sessions were required. Separately, in 7, 14 and 21 days of treatment, the clinical efficacy, behavior nerve determination score and adverse reaction were observed in the two groups.

RESULTSIn 7, 14 and 21 days of treatment, the total effective rates were 50. 0% (16/32), 68. 8% (22/32) and 78. 1% (25/32) in the observation group and were 69. 0% (20/29), 72. 4% (21/29) and 82. 8% (24/29) in the control group. The result in the control group was better than that in the observation group in the 7 days (P< 0. 05). The behavior determination scores in 7, 14 and 21 days were all improved obviously as compared with those before treatment in the two groups (P<0. 05, P<0. 01). The score in the control group was better than that in the, observation group in the 7 days (P<0. 05). The differences were not significant in the scores between the two groups in 14 and 21 days (both P>0. 05). The incidence of adverse reaction in the observation group was lower than that in, the control group [14. 3% (5/35) vs 31. 4% (11/35), P<0. 05] and the severity was mild.

CONCLUSIONIn the treatment of NHIE with the combined therapy of acupuncture and acupint injection, the overall efficacy in 1 week; is inferior to that of the combined therapy of the intravenous drop of citicoline sodium and intramuscular injection of NGF. But the efficacy is improved gradually along with the treatment progression and the adverse reaction is less.

Acupuncture Points ; Acupuncture Therapy ; Female ; Follow-Up Studies ; Humans ; Hypoxia-Ischemia, Brain ; drug therapy ; therapy ; Infant ; Infant, Newborn ; Male ; Nerve Growth Factor ; administration & dosage

The paper analyzed the problems of preparing before class,exerting teaching methods,applying multimedia and summarizing after class in neurology teaching and brought forward some solving countermeasures.

Based on the relationships between Humanistic Education and specialized education,the article illuminates the feasibility,the methods and ways to develop humanistic education in university.

Anticipatory nausea and vomiting (ANV) is one of the common adverse effects in cancer patients undergoing chemotherapy.ANV is related to classical conditioning,psychosocial and demographic factors.Psychological intervention such as systematic desensitization,hypnosis and biofeedback therapy could be used to treat ANV,while some psychotropic medication including benzodiazepines and olanzapine is also helpful to prevent ANV.Now the recognition about ANV in clinical oncology is not adequate and large sample epidemiological survey of ANV is lacked.So far there are no special tools to predict and assess ANV,and the effects of pharmacological interventions also need solid evidence from large sample double-blind randomized controlled trials.

Objective To analyze the epidemiological characteristics of public health emergencies and the situation of report and control of public health emergencies in Qijiang District of Chongqing M unicipality during 2009-2013 to provide a scientific ba‐sis for the prevention and control of public health emergencies .Methods The descriptive epidemiology method was used to analyze the directly network reported data of the public health emergencies in Qijiang District during 2009-2013 from the National Emer‐gency Public Health Emergencies Reporting Management System .Results Total 47 public health emergencies were reported in Qi‐jiang District during 2009-2013 ,including 994 cases of caused disease and 1 case of death (food poisoning) .Most of the emergen‐cies were caused by infectious diseases events ,accounting for 82 .78% (39/47) ,food poisoning and other public health emergencies (dog bites) accounted for 2 .13% (1/47) and 14 .89% (7/47)respectively .Respiratory disease events accounted for 78 .72% (37/47) of total infectious diseases events ,the majority were influenza A (H1N1) flu and epidemic parotiditis .The high‐incidence seasons were from April to May(accounting for 34 .04% )and October(40 .42% ) .The most cases happened to the school (especially infec‐tious diseases) ,accounting for 80 .85% of the total events .Conclusion The respiratory infectious disease in the prevailing season is the priority of prevention and control on public health emergencies in Qijiang District .Attentions should be highly paid to the pre‐vention and control of public health emergencies (especially in rural schools);meanwhile ,the dog management and propaganda of prevention and control knowledge should be strengthened to effectively eliminate the potential of hydrophobia .

Currently,heart failure is one common disease causing serious damage to children's health and life which has high missed diagnosis rate and mortality.Accurate and effective evaluation of pediatric cardiac function is of great importance in the treatment,surveillance and prognosis of disease.Tei index was first presen-ted by Japanese scholars as a new comprehensive indicator of global (combined systolic and diastolic)myocar-dial function.It was defined as a ratio between the sum of isovolumic times (ICT and IRT)and ejection time (ET).This index can be measured by a simple,reproducible and non-invasive method regardless of changes in the heart rate or ventricular shape and other external factors.The sensitivity for ventricular dysfunction could be high.Tei index has been used more and more often in the clinical evaluation of cardiac function especially in children.This paper reviews the measurement methods,related factors and pediatric clinical application progress of Tei index.

Objective:To summarize the application of hospital electronic medical record system and implementation experience, for the scientific and reasonable construction of digital hospital provides design scheme. Methods: The electronic medical record to the patient as the center including the establishment of hospital medical records, doctor's orders, all kinds of inspection, inspection reports and other information. Results: The uniform ultimate implementation of electronic health record standard, electronic data from medical records and medical information barrier-free exchange, realize the integration and sharing of electronic medical records information inside the hospital. Conclusion: The electronic medical record system to improve the clinical efficiency in hospital application, provide auxiliary functions for clinical decision making.

Objective To investigate the distribution and significance of CD20 positive cells in the early human embryo. Methods Distribution and morphology of CD20 positive cells in 10 specimens of human embryo aged from 6 to 7 weeks were brown,and studied with immunohistochemical method. Results 1.CD20 positive cells appeared in the liver of early human embryo.2.The immunohistochemical positive substances were brown,and found chiefly in the nuclei of B cells as unevenly-distributed granules,and were not detected in the cytoplasma and on the cell membrane.Conclusion The accuracy of location and distribution of CD20 positive cells in the nuclei of B cells of early human embryo liver may provide an important clue for further exploration of the functional mechanism of CD20 in the process of B cell proliferation and differentiation.