1.The Development of Xeno-transplantation and Medical Ethical Reflection
Chinese Medical Ethics 1995;0(03):-
The basic research and development of xeno-transplantation technique has been a new field. The article analyzed its current situation and problems, discussed the ethical problems the researchers and physicians faced, and raised a series of ethical principles which should be obeyed in xeno-transplantation, that is: stick to combining humanism and utilitarianism; observe the technological and sanitary criterion, choose the graft cautiously; Be attentive and loyal to the recipient's health; no harm and beneficial to the humankind. Besides, the article explored the importance of setting up laws and regulations about xeno-transplantation.
3.Application of enzyme catalytic reaction with ultrasonic wave to Chinese materia medica and natural products
Chinese Traditional and Herbal Drugs 1994;0(08):-
The enzyme,as a biocatalyst,can not be surpassed in speeding up the reactions by other common chemical catalysts under the suitable conditions and can catalyze the reaction mildly,simplify the facilities needed,improve the work conditions,and reduce the production costs,etc.Those are its advantages mentioned above.But while the enzyme is extracted outside the cells,the molecular conformation may be changed with decreasing its bioactivity and stability seriously.As one type of physical energy,(ultrasonic) wave with lower intensity and suitable frequency can make the conformation of enzymatic molecular comformation transform positively and the transforming reactions accelerate so as to facilitate the effective constituents of Chinese materia medica and natural products transforming.
4.Numerical Simulation of CO_2 Removal with Carbon Molecular Sieve for Use in Portable Life Support System
Space Medicine & Medical Engineering 2006;0(06):-
Objective To establish a numerical model of adsorption and desorption of CO_2 and to study the influencing factors on the removal system. Method A physical model was expressed by mathematical method, then an isothermal adsorption model for simulating molecular sieve was established. Result The working process of a CO_2 removed device was simulated and its result was analized with the established model.The characteristics of the adsorption and desorption was obtained. Conclusion The model describes the processes correctly, the influencing factors like humidity dimension of the bed are considered simultaneously.It remains to be improved by further experimental corrections.
5.Relationship between nurses′personality, family function and psychological resilience
Chinese Journal of Practical Nursing 2017;33(21):1654-1658
Objective To investigate the status of personality, family function and psychological resilience towards employed nurses, and to explore the relationship among personality, family function and psychological resilience. Methods Four instruments were applied to investigate 240 employed nurses from comprehensive Grade 3A hospital of Fujian Province, which were the Characteristics Questionnaire, Family Intimacy Scale (FACEⅡ-CV), Self-resilience Scale and Personality Traits Questionnaire. Results The correlation analysis showed that nurses′ personality traits, family functions and psychological resilience were closely related. The multiple regression and analysis showed that 40%of the variance for employed nurses′psychological resilience could be explained through considering personality dimensions, family cohesion and adaptability. Conclusions Personality, family functions and psychological resilience towards employed nurses are closely related as both internal and external protective factors.
6.The effects of two surgical treatment on idiopathic scoliosis
Chinese Journal of Primary Medicine and Pharmacy 2011;18(3):323-324
Objective To study and compare the effects of different surgical operation in treatment of adolescent idiopathic seoliosis. Methods 70 patients with adolescent idiopathic seoliosis and patients informed consent were selected as research object,and they were divided into group A 35 cases and group B 35 cases according to their willingness, and they were separately treated with videoassisted anterior thoracoscopic correction and traditional anterior thoracoscopic correction, then the surgical time, complications, hospital stays, rates of patients satisfaction, total effective rate and Cobb, before and after the treatment were detected and compared. Results The surgical time [(225.6 ± 30. 8) min] and hospital stays [(2. 7 ± 0. 8) d] of group A were all shorter than those of group B [( 365. 4 ±23. 8) min, (4. 8 ± 1.2 ) d] ( t = 3.26,3.78, all P < 0. 05 ), complications rate ( 8. 6% ) was lower than that of group B (20. 0% ) ( x2 = 3. 45, P < 0. 05 ), rates of patients satisfaction ( 97. 1% ) and total effective ( 97. 1% ) were higher than those of group B(80. 0% ,85.75% ) (x2 =2. 85,3.01 ,all P <0.05) ,Cobb( 14. 2 ± 5.4)°was smaller than that of group B(23. 4 ±5.6) °(t =2. 97 ,P < 0. 05). Conclusion The effect of vidcoassisted anterior thoracoscopic correction in treatment of adolescent idiopathic seoliosis was good,and complications rate was low and it was worthy of extend and application.
7.Proprotein convertase subtilisin/kexin type 9 and regulation of lipid metabolism
International Journal of Cerebrovascular Diseases 2009;17(3):211-215
Hypercholesterolemia and coronary heart disease caused by it have become the most important factors threatening human health. The lipid metabolism-related studies are increasingly receiving attention. Recent studies have demonstrated that proprotein convertase subtilisin/kexin type 9 (PCSK9), a family member of precursor protein-converting enzyme, plays an important role in the regulation of lipid metabolism. The expression and mutation of PCSK9 gene are closely correlated with the content of low-density lipoprotein receptor (LDLR). The excessive expression of PCSK9 promotes the degradation of LDLR, thereby increasing the levels of plasma LDL; whereas the inhibition of PCSK9 gene expression causes the decreased levels of plasma LDL. Therefore, it is promising to develop novel medications for treating hypercholesterolemia, controlling hyperlipermia and preventing coronary heart disease by studying the mechanism of PCSK9.
8.Progress on study on oral lesions in patients with AIDS
Journal of Peking University(Health Sciences) 2004;0(01):-
A large number of studies showed that hairy leukoplakia,pseudomembranous candidiasis,Kaposi' sarcoma,non-Hodgkin's lymphoma,linear gingival erythema,necrotizing ulcerative periodontitis and necrotizing ulcerative gingivitis were the most common lesions in patients with HIV infection and AIDS,and their higher prevalence and incidence rates correlated with the falling CD4 counts and higher virus load of the patients.The use of highly active antiretroviral therapy(HAART) was associated with decreases in the prevalence of oral diseases.Oral manifestations may represent early signs of AIDS di-sease and call attention to disease progression.Oral fluid has been shown to possess superior sensitivity for HIV antibody detection as serum.Abstract:SUMM ARY A large number of stud ies showed that hairy leukoplakia,pseudomembranous cand id iasis,decreases in the prevalence of oral d iseases.Oral manifestations may represent early signs of AIDS d i-sease and call attention to d isease progression.Oral fluid has been shown to possess superior sensitivity forHIV antibody detection as serum.Kaposi’sarcoma,non-Hodgkin’s lymphoma,linear gingival erythema,necrotizing ulcerative periodonti-tis and necrotizing ulcerative gingivitis were the most common lesions in patients with HIV infection and AIDS,and their higher prevalence and incidence rates correlated with the falling CD4 counts and higher virus load of the patients.The use of highly active antiretroviral therapy(HAART) was associated with
9.Effect of Astragalus membranaceus and Angelica sinensis on the hemodynamics of restenosis of blood vessel in rat
Medical Journal of Chinese People's Liberation Army 2001;0(08):-
Objective To investigate the effects of Astragalus membranaceus and Angelica sinensis on the hemodynamics and pathological features of arterial wall in restenosis of blood vessel in rats in order to find the potential mechanism of the effect of Astragalus membranaceus and Angelica sinensis in preventing restenosis after ablation of intima. Method Thirty SD rats were randomly divided into 5 groups (6 each):control group (C),model group (M),Astragalus membranaceus treatment group (H),Angelica sinensis treatment group (D),and combined Astragalus membranaceus with Angelica sinensis treatment group (HD). The restenosis model was reproduced by denuding rat's aorta endothelium with balloon catheter in all the groups except group C. After intramuscular injection of Astragalus membranaceus 0.42ml/(kg?d) in group H,Angelica sinensis 0.21ml/(kg?d) in group D,and Astragalus membranaceus 0.42ml/(kg?d) together with Angelica sinensis 0.21ml/(kg?d) in group HD for 21 days,the changes in hemodynamics and the pathological features of arterial wall were observed in all the groups. Result Compared with rats of group C,in which the intima was smooth and the smooth muscle cells (VSMCs) in media were orderly arranged,the intimal thickness of aorta,pulsatile index (PI) and resistance index (RI) increased,while the diameter of lumen,blood velocity decreased remarkably in group M. Compared with the rats in group M,the extent of hyperplasia and thickness was notably reduced,RI and PI were lower while blood velocity was lowered in group H,D and HD after being treated for 21 days. Conclusion Hyperplasia induced by remaval of endothelial cells may be reduced and blood circulation may be improved to different extents by individually or simultaneously use of Astragalus membranaceus and Angelica sinensis,thus preventing restenosis of the aorta after removal of its intima.
10.Studies on the Chemical Constituents of Korean Monkshood (Aconitum coreanum)
Chinese Traditional and Herbal Drugs 1994;0(12):-
The compounds were isolated from Aoonitum coreanum (Lev1.) Rapaics and identificd by TLC, IR, MS and NMR, as ?-sitosterol (Ⅰ), daucosterol (Ⅱ), Guan-Fu base A (Ⅲ),GuanFu bas. G (Ⅳ), condelphine (Ⅴ), Guan-Fu base Ⅰ (Ⅵ), hetisinone (Ⅶ), isoatisinum chloride (Ⅷ), atisinum chloride (Ⅸ), and Guan-Fu base z (Ⅹ) from the root. Compounds Ⅲ and Ⅸ were also found in the aerial parts of the plant. compounds Ⅱ, Ⅴ, Ⅶ and Ⅷ were obtained for the first time from this plant. Most of them exhibited antiarrhythmic activlty.