Objective To evaluate the accuracy of the soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) and lipopolysaccharide binding protein (LBP) as diagnostic indices for neonatal serious bacterial infections (SBI). Methods A total of 171 newborns were enrolled in the study, and were classiifed into SBI group (including early-onset and late-onset), non-SBI group according to clinical manifestations, laboratory examinations and the time of disease onset. Serum sTREM-1, LBP and C-reactive protein (CRP) levels were measured. Receiver operator characteristic curve (ROC) was drawn, and the area under curve (AUC) was calculated. Each index was evaluated for the diagnostic value of neonatal SBI. Results The sTREM-1 and LBP levels were signiifcantly higher in SBI group than those in non-SBI group (P=0.000). The AUC of ROC for sTREM-1, LBP and CRP in early-onset SBI was 0.888, 0.839 and 0.706, respectively. The AUC of ROC for sTREM-1, LBP and CRP in late-onset SBI was 0.860, 0.865 and 0.705, respectively. Conclusions Both sTREM-1 and LBP are useful for the diag-nosis of neonatal SBI.

BACKGROUND: Fiber posts are currently perceived as promising alternatives to cast metal posts, as their elastic modulus are similar to that of dentin, producing a favorable stress distribution and providing more esthetic outcomes for endodontically treated teeth. Failure of a fiber post and composite resin core often occurs at the junction between the two materials. This failure process requires better characterization.OBJECTIVE: To compare the bond strength of fiber posts after three surface treatments to a composite resin. METHODS: The coronal portions of 20 mandibular premolars with a single root canal were removed and were endodontically treated. After post space preparation, the roots were divided into four groups and the fiber posts and resin cores were lured. In the three testing groups, the surfaces of fiber posts were silaned, sandblasted or etched with hydrogen peroxide. In the control group, the surfaces of fiber posts were not treated. All specimens were exposed to cyclic loadings and thermal cycles. The roots were sectioned into slices with 1 mm thickness and their bond strengths were tested with a universal material testing machine. Test piece following testing was placed under optical microscope to observe the breakage method.RESULTS AND CONCLUSION: Stickiness strength was significantly greater in the sandblasted and hydrogen peroxide groups compared with the control group (P < 0.05). No significant difference in stickiness strength was determined between the sandblasted and hydrogen peroxide groups (P > 0.05). No significant difference in stickiness strength was detected between the silaned and control groups (P > 0.05). The splicing destruction among each group was the main breakage method between materials and fiber posts. The surface treatment of fiber posts with sandblast or hydrogen peroxide significantly enhanced the bond strength of the composite resin tested. The surface treatment of fiber posts with silane did not enhance the bond strength of the composite resin.

Objective To analyze the epidemiological characteristics of public health emergencies and the situation of report and control of public health emergencies in Qijiang District of Chongqing M unicipality during 2009-2013 to provide a scientific ba‐sis for the prevention and control of public health emergencies .Methods The descriptive epidemiology method was used to analyze the directly network reported data of the public health emergencies in Qijiang District during 2009-2013 from the National Emer‐gency Public Health Emergencies Reporting Management System .Results Total 47 public health emergencies were reported in Qi‐jiang District during 2009-2013 ,including 994 cases of caused disease and 1 case of death (food poisoning) .Most of the emergen‐cies were caused by infectious diseases events ,accounting for 82 .78% (39/47) ,food poisoning and other public health emergencies (dog bites) accounted for 2 .13% (1/47) and 14 .89% (7/47)respectively .Respiratory disease events accounted for 78 .72% (37/47) of total infectious diseases events ,the majority were influenza A (H1N1) flu and epidemic parotiditis .The high‐incidence seasons were from April to May(accounting for 34 .04% )and October(40 .42% ) .The most cases happened to the school (especially infec‐tious diseases) ,accounting for 80 .85% of the total events .Conclusion The respiratory infectious disease in the prevailing season is the priority of prevention and control on public health emergencies in Qijiang District .Attentions should be highly paid to the pre‐vention and control of public health emergencies (especially in rural schools);meanwhile ,the dog management and propaganda of prevention and control knowledge should be strengthened to effectively eliminate the potential of hydrophobia .

Objective To study the effect of Lamivudine therapy in preventing disease progression in patients with the chronic serious hepatitis B during the short-term. Methods 40 patients with the chronic serious hepatitis B, who have the trend of developing severe hepatitis,were randomized into treating group(n=20) and control group (n=20).The two groups were given the same synthetic treatment. Treating group was given Iamivudine 100mg daily in addition, for 8 weeks. Effects were assessed by clinical , biochemical , the incidence of chronic severe hepatitis,suvival rates and virologic parameters. Results (1) After 8-weeks treatment , the incidence of chronic severe hepatitis in treating group was lower than in control group(X~2=4. S1 ,P

OBJECTIVE: To establish a RP-HPLC method for the content determination of amphotericin B in amphotericin B vaginal effervescent tablets.METHODS: HPLC was performed on Kromasil C18 column with the mobile phase consisted of 0.01 mol ?L-1 potassium dihydrogen-acetonitrile(66∶34) at a flow rate of 1.0 mL?min-1.The detection wavelength was set at 408 nm;the sample size was 10 ?L,and the column temperature was set at room temperature.RESULTS: The linearity of amphotericin B was good in the range of 0.404～3.636 ?g(r=0.999 4) and the average recovery rate was 99.39%(RSD=0.22%,n=6).CONCLUSIONS: The method is simple,accurate,feasible,and it can be used for the determination of this tablets.

Twenty six Wistar rats were divided into three groups: (1) Exposed towhole body blasts, (2) Exposed to head blasts and (3) Control group. The blast wave was gener-ated by compressed air operated shock tube. The purpose of this study was to observe theeffect of blast injury on conditional avoidance response (CAR) in rats. The results wereas follow: (1) After exposured, decreasing of acquisition of CAR was observed in bothblast groups within 5 days (P0.05). (3) The retention of CAR of group 2 is significantly lower than that of controls(P

0.05).The splicing destruction among each group was the main breakage method between materials and fiber posts.The surface treatment of fiber posts with sandblast or hydrogen peroxide significantly enhanced the bond strength of the composite resin tested.The surface treatment of fiber posts with silane did not enhance the bond strength of the composite resin.

Objective To evaluate the blood-saving effect of tranexamic acid in elderly patients undergoing total hip replacement.Methods One hundred and sixty ASA Ⅱ or Ⅲ patientss of both sexes,aged 65-70 yr,with a body mass index of 16-22kg/m2,undergoing total hip replacement,were randomly divided into 2 groups(n =80,each):control group(group C)and tranexamic acid group(group T).Anesthesia was induced with midazolam,fentanyl,etomidate and atracurium.The patients were tracheal intubated and mechanically ventilated.PEr CO2 was maintained at 35-45 mm Hg.Aneslhesia was maintained with propofol,remifentanil and atracurium.Before the skin incision,tranexamic acid 15 mg/kg was infused over 15 m in in group T,while the equal volume of normal saline was given instead in group C.Hemoglobin(Hb),platelet count(PLT),prothrombin time(PT),and activated partial thromboplastin time(APTT)were monitored during operation to guide blood transfusion.Intraoperative and postoperative blood loss and allogeneic blood transfusion were recorded.Postoperative complications were also recorded.Results There was no significant difference in the amount of intraoperative blood loss between the two groups(P ＞ 0.05).The amount of postoperative blood loss was significantly smaller and less allogeneic red blood cell was transfused in group T than in group C(P ＜ 0.05).No complications occurred after operation in either group.Conchusion Tranexamic acid has blood-saving effect in elderly patients undergoing total hip replacement,but the clinical value is limited.

Objective To observe the relationship of the Janus kinase-signal transducers and activator of transcription pathway and neurogenesis in the lateral ventricle subventricular zone(SVZ) and choroid plexus of neonatal rats with periventricular leukomalacia(PVL).Methods PVL models were established by right common carotid artery ligation followed by 4 h 60 mL/L oxygen exposure in 2-day-rat;the neonatal rats performed a sham operation,without hypoxia-ischemia were used as control group.The rats were sacrificed at 0 h,3 h,6 h,12 h,1 d,3 d and 7 d after hypoxic-ischemic(HI),and brain tissues were collected,immunohistochemistry was used to detect the expression of P-STAT3 and Nestin in the subventricular zone and choroid plexus.Results Very low expressions of P-STAT3 and Nestin were observed in lateral ventricle SVZ and choroid plexus in control group.The expression levels of P-STAT3 and Nestin increased significantly after HI,peaked at 1 d and 3 d separately,and remained at a higher level at 7 d after HI,demonstrating significant differences at each time point compared with those in control group(Pa

0.05).It was revealed by ROC curve analysis that P-LAP≤38.12 U/L and IL-6≥3.40 pg/mL could be adopted as criteria to predict the inevitable preterm labor,and the Youden's index of the combination use of the parameters of P-LAP and IL-6 was significantly higher than that of the single use of each parameter(P