Objective To investigate the mechanism of inter fe ron-? (IFN?) in preventing hepatic fibrosis in rat experimental model . Methods Thirty-six male Sprague-Dawley rats were divide d into three groups randomly: group A(normal controls)of 12 rats were given norm al food and water and received subcutaneous injection of peanut oil twice weekly ; group B (fibrotic model)and group C (IFN? prevention) with 12 rats in eac h were induced by carbon terrachloride, high cholesterol and low protein. Group C were treated with intramusclular injections of IFN? in saline, administered daily at the doses of 1?10 5U. At the end of the sixth week, all the rats in each group were killed, the liver function was examined and the samples of t he liver obtained by biopsy were submitted to histological liver fibrosis studie s. The expressions of ?-smooth muscle actin in hepatic tissues were detect ed with immunohistochemical methods. The effect of IFN? on apoptosis of hep atic stellate cells (HSC) were investigated under electron microscope. Results The level of hepatic collagen Ⅰand Ⅲ and serum PC Ⅲ, HA, and LN in group C was significantly lower than that of group B under lig ht microscope (P

The difference of gene expression profile changes in Barrett's esophagus (BE) and cardia intestinal metaplasia (CIM) epithelium was studied and the novel associated genes were screened in the early stage by cDNA microarray. The cDNA retro-transcribed from equal quantity mRNA from BE and CIM epithelial tissues were labeled with Cy3 and Cy5 fluorescence as probes. The mixed probe was hybridized with three pieces BiostarH-40s double dot human whole gene chip. The chips were scanned with a ScanArray 4000. The acquired images were analyzed using GenePix Pro 3.0 software. It was found a total of 141 genes were screened out that exhibited differentially expression more than 2 times in all three chips. It was identified that in gene expression profiles of BE, 74 genes were up-regulated and 67 down-regulated as compared with CIM. The comparison between the difference of gene expression profile changes in BE and CIM epithelia revealed that there existed the difference between BE and CIM at gene level. 141 genes with the expression more than two time were probably related to the occurrence and development of BE and the promotion or progress in adenocarcinoma.

Objective To study the protein conformational change of placenta tissue by using Raman spectrum.Methods By using Raman spectroanalysis,we detected the placenta protein conformational change of GDM and control groups.Results(1)In the placenta of GDM,the absorption bands of tryptophan and phenylalanine were increased obviously.(2)In the placenta of GDM,the secondary structure of protein was composed of α-helix,random coil and β-sheet.Conclusions In the placenta of GDM,the orderly conformations of main chains in protein are decreased.Side chains of amino acids,especially tryptophan and phenyl-alanine,are changed greatly.The structure variation of protein may be correlated to the diabetic complications.

Objective To explore the clinical guiding value of spiral computed tomography(SCT)with three-dimensional computed tomography reconstruction(3-DCT)in percutaneous kyphoplasty(PKP).Methods 24 patients prepared to be treated with PKP were examined under 3-DCT before the treatment.Results According to the contra-indications shown by 3-DCT,11 patients' operation were cancelled;the others were treated with PKP and got good outcomes due to the accurate data provided by 3-DCT.Conclusion SCT plays an important role in PKP.

0 05). The positive rate of HbeAg (35 7%) in multiple group was significantly lower than in single group ( P 0 05) However, the incidences of premature rupture of membrane (PROM), premature delivery, 28 1%,25 0% fetal distress and newborn infant asphyxia 31 3%,25 0% in multiple hepatitis virus infection group were significantly higher than in single hepatitis virus infection group ( P

Bilingual teaching is a positive exploration of raising high quality talented persons under the new situation.It exists some problems in local college bilingual teaching such as the shortage of teachers,standard teaching materials,proper students level,management measures and so on.Local colleges should strengthen training the teachers,vigorously introduce the talented persons;do well the bilingual teaching material construction through many ways,teach students in accordance with their aptitude, standardize management and establish the scientific teaching appraisal mechanism.

Noun and verb are always two primary lexical knowledge information in all kinds of languages. It plays an important role in the structure and function of the language. Cognitive activation and differential neural basis when aphasiacs distinguish from these two kinds of lexical knowledge information is the focus of subjects, such as neuropsychology, neurolinguistics and neuroimage. The specific deficit regarding the precessing of noun and verb was analyzed in the article with the data of this aphasiac.

ObjectiveTo investigate the characteristic of aphasia after left Basal ganglia injured.Methods10 cases with focus at left Basal ganglia and aphasia were assessed with Chinese Rehabilitation Research Center's Chinese Standard Aphasia Examination 12 weeks after stroke.Results and ConclusionThe characteristics of these 10 patients did not only show similar to the characteristics of Basal ganglia aphasia,but some other features.The relationship of the symptom and imaging finding has been discussed.

Since the symptoms and mechanism of poststroke aphasia are various and complicated, there are a great deal of problems which are difficult to resolve yet. At the aspect of aphasia research, Chinese and Western medicine have different emphases, Chinese medicine emphasizes particularly on therapy, Western medicine emphasizes on discussing mechanism of aphasia, all kinds of sorts and evaluation of aphasia and pertinence rehabilitation, and so on; modern research methods include neurolinguistics, neuropsychology, cognitive science, neurorehabilitation, neuroelectrophysiology, neuroimage and so on, all these means of aphasia research often involve in cross multi-subject, furthermore becoming powerful implement of recognizing brain mechanism.

Objective:To investigate the behavior of tobacco use among migrants in construction sites and explore the associated factors .Methods: A total of 652 migrants in 10 construction sites were selected in Xi’ an and Tongchuan .Chi-square and logistic regression were used to analyze the influencing factors of tobacco use.Results:The average age of the migrants in the construction site was (38.23 ± 10.61), and males occupied 82.7%(535/647) of the total.The current smoking rate of the migrants was 55.8%(364/652), with 64.3%(344/535) in males and 14.3%(16/112) in females.82.5%(329/399) smokers wanted to quit smoke , however only 52.7%(210/399) had tried quitting smoking in action, and 8.8%(35/399) quitted smoking successfully .Multivariable regression indicated that the migrants who were at lower age , and sick within 2 weeks, had perceived not difficult to stop smoking and who disagree with the benefits of smoking were more likely to try to quit smoking .Conclusion:Migrants in construction sites show their characteristics of old age , low level of health literacy , male-domination , high smoking rate and high intention of quitting smoking .Tobacco control projects should be implemented in construction sites to promote the translation of smoking quitting intention into action .